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Olfactory ensheathing cell tumor arising from the olfactory mucosa.

Ogino-Nishimura E, Nakagawa T, Mikami Y, Ito J - Case Rep Med (2012)

Bottom Line: A female presented a large soft mass extending medially to the olfactory cleft and laterally to the middle meatus in the left nasal cavity.Imaging studies confirmed a cystic mass extending superiorly into the frontal lobe, indicating that the tumor arouse from the olfactory mucosa.Immunohistochemically constituent cells were diffusely positive for S-100 protein, but olfactory ensheathing cell tumor was diagnosed by negative staining for Leu7 (CD57).

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

ABSTRACT
We report a rare case of olfactory ensheathing cell tumor. A female presented a large soft mass extending medially to the olfactory cleft and laterally to the middle meatus in the left nasal cavity. Imaging studies confirmed a cystic mass extending superiorly into the frontal lobe, indicating that the tumor arouse from the olfactory mucosa. A subtotal resection was achieved through an endoscopic endonasal approach without operative complications. Immunohistochemically constituent cells were diffusely positive for S-100 protein, but olfactory ensheathing cell tumor was diagnosed by negative staining for Leu7 (CD57). This case indicates that olfactory ensheathing cell tumor should be included in differential diagnoses for the olfactory cleft tumors.

No MeSH data available.


Related in: MedlinePlus

Hematoxylin and eosin (HE) staining shows that the tumor is composed of spindle cells with eosinophilic cytoplasm (a). Immunohistochemistry demonstrates that the tumor is strongly positive for S100 (b) and neuron-specific enolase (NSE, (d)), weakly positive for synaptophysin (SYN, (f)), and is negative for Leu7 (c) and epithelial membrane antigen (EMA, (e)). In immunohistochemistry, nuclear staining with hematoxylin was performed. Scale bar in (f) represents 50 μm for (a)–(f).
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fig2: Hematoxylin and eosin (HE) staining shows that the tumor is composed of spindle cells with eosinophilic cytoplasm (a). Immunohistochemistry demonstrates that the tumor is strongly positive for S100 (b) and neuron-specific enolase (NSE, (d)), weakly positive for synaptophysin (SYN, (f)), and is negative for Leu7 (c) and epithelial membrane antigen (EMA, (e)). In immunohistochemistry, nuclear staining with hematoxylin was performed. Scale bar in (f) represents 50 μm for (a)–(f).

Mentions: Microscopic examination of the resected tumor demonstrated a neoplasm composed of spindle cells with eosinophilic cytoplasms and elongated or wavy nuclei with occasional symplastic changes (Figure 2(a)). The mitotic index was less than one per ten high-power fields, and there was no geographic tumor necrosis. All features were apparently compatible with schwannomas. Immunohistochemically, the spindle cells were diffusely positive for S-100 protein, neuron-specific enolase, and synaptophysin (Figures 2(b), 2(d), and 2(f)), and negative for epithelial membrane antigen (Figure 2(e)), which also supported the diagnosis of schwannoma, although Leu7 was completely negative (Figure 2(c)). The Ki-67 labeling index was 2%. These results were considered to best fit with a diagnosis of olfactory ensheathing cell tumor.


Olfactory ensheathing cell tumor arising from the olfactory mucosa.

Ogino-Nishimura E, Nakagawa T, Mikami Y, Ito J - Case Rep Med (2012)

Hematoxylin and eosin (HE) staining shows that the tumor is composed of spindle cells with eosinophilic cytoplasm (a). Immunohistochemistry demonstrates that the tumor is strongly positive for S100 (b) and neuron-specific enolase (NSE, (d)), weakly positive for synaptophysin (SYN, (f)), and is negative for Leu7 (c) and epithelial membrane antigen (EMA, (e)). In immunohistochemistry, nuclear staining with hematoxylin was performed. Scale bar in (f) represents 50 μm for (a)–(f).
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3368184&req=5

fig2: Hematoxylin and eosin (HE) staining shows that the tumor is composed of spindle cells with eosinophilic cytoplasm (a). Immunohistochemistry demonstrates that the tumor is strongly positive for S100 (b) and neuron-specific enolase (NSE, (d)), weakly positive for synaptophysin (SYN, (f)), and is negative for Leu7 (c) and epithelial membrane antigen (EMA, (e)). In immunohistochemistry, nuclear staining with hematoxylin was performed. Scale bar in (f) represents 50 μm for (a)–(f).
Mentions: Microscopic examination of the resected tumor demonstrated a neoplasm composed of spindle cells with eosinophilic cytoplasms and elongated or wavy nuclei with occasional symplastic changes (Figure 2(a)). The mitotic index was less than one per ten high-power fields, and there was no geographic tumor necrosis. All features were apparently compatible with schwannomas. Immunohistochemically, the spindle cells were diffusely positive for S-100 protein, neuron-specific enolase, and synaptophysin (Figures 2(b), 2(d), and 2(f)), and negative for epithelial membrane antigen (Figure 2(e)), which also supported the diagnosis of schwannoma, although Leu7 was completely negative (Figure 2(c)). The Ki-67 labeling index was 2%. These results were considered to best fit with a diagnosis of olfactory ensheathing cell tumor.

Bottom Line: A female presented a large soft mass extending medially to the olfactory cleft and laterally to the middle meatus in the left nasal cavity.Imaging studies confirmed a cystic mass extending superiorly into the frontal lobe, indicating that the tumor arouse from the olfactory mucosa.Immunohistochemically constituent cells were diffusely positive for S-100 protein, but olfactory ensheathing cell tumor was diagnosed by negative staining for Leu7 (CD57).

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

ABSTRACT
We report a rare case of olfactory ensheathing cell tumor. A female presented a large soft mass extending medially to the olfactory cleft and laterally to the middle meatus in the left nasal cavity. Imaging studies confirmed a cystic mass extending superiorly into the frontal lobe, indicating that the tumor arouse from the olfactory mucosa. A subtotal resection was achieved through an endoscopic endonasal approach without operative complications. Immunohistochemically constituent cells were diffusely positive for S-100 protein, but olfactory ensheathing cell tumor was diagnosed by negative staining for Leu7 (CD57). This case indicates that olfactory ensheathing cell tumor should be included in differential diagnoses for the olfactory cleft tumors.

No MeSH data available.


Related in: MedlinePlus