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Olfactory ensheathing cell tumor arising from the olfactory mucosa.

Ogino-Nishimura E, Nakagawa T, Mikami Y, Ito J - Case Rep Med (2012)

Bottom Line: A female presented a large soft mass extending medially to the olfactory cleft and laterally to the middle meatus in the left nasal cavity.Imaging studies confirmed a cystic mass extending superiorly into the frontal lobe, indicating that the tumor arouse from the olfactory mucosa.Immunohistochemically constituent cells were diffusely positive for S-100 protein, but olfactory ensheathing cell tumor was diagnosed by negative staining for Leu7 (CD57).

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

ABSTRACT
We report a rare case of olfactory ensheathing cell tumor. A female presented a large soft mass extending medially to the olfactory cleft and laterally to the middle meatus in the left nasal cavity. Imaging studies confirmed a cystic mass extending superiorly into the frontal lobe, indicating that the tumor arouse from the olfactory mucosa. A subtotal resection was achieved through an endoscopic endonasal approach without operative complications. Immunohistochemically constituent cells were diffusely positive for S-100 protein, but olfactory ensheathing cell tumor was diagnosed by negative staining for Leu7 (CD57). This case indicates that olfactory ensheathing cell tumor should be included in differential diagnoses for the olfactory cleft tumors.

No MeSH data available.


Related in: MedlinePlus

Preoperative computed tomography (a), and magnetic resonance images ((b) coronal, (c) sagittal, and (d) axial) show a cystic mass extending from the left olfactory cleft to the olfactory groove. An endoscopic image (e) shows the tumor extending from the olfactory cleft to the middle meatus (arrowheads). MT: middle turbinate. Magnetic resonance images two years after operation show no recurrence of tumors (f)–(h).
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fig1: Preoperative computed tomography (a), and magnetic resonance images ((b) coronal, (c) sagittal, and (d) axial) show a cystic mass extending from the left olfactory cleft to the olfactory groove. An endoscopic image (e) shows the tumor extending from the olfactory cleft to the middle meatus (arrowheads). MT: middle turbinate. Magnetic resonance images two years after operation show no recurrence of tumors (f)–(h).

Mentions: Nasal endoscopy demonstrated a soft, whitish mass occupying the olfactory cleft and extending laterally to the middle meatus, with destruction of the middle turbinate in the left nostril. Computed tomography (CT) displayed a lesion at the olfactory cleft that extended superiorly to the olfactory groove, with a bone defect in the skull base (Figure 1(a)). The cribriform plate was elevated upward indicating that the tumor originated from the extracranial compartment. Magnetic resonance imaging (MRI) revealed a mass showing cystic changes (Figures 1(b)–1(d)), with solid portions demonstrating strong postgadolinium contrast enhancement. Our initial diagnosis based on radiographic findings was esthesioneuroblastoma. Partial resection of the tumor in the olfactory cleft was then performed using the endoscopic endonasal approach under local anesthesia, which suggested a histopathologic diagnosis of schwannoma. Based on this result, we planned subtotal resection of the tumor via an endoscopic endonasal approach.


Olfactory ensheathing cell tumor arising from the olfactory mucosa.

Ogino-Nishimura E, Nakagawa T, Mikami Y, Ito J - Case Rep Med (2012)

Preoperative computed tomography (a), and magnetic resonance images ((b) coronal, (c) sagittal, and (d) axial) show a cystic mass extending from the left olfactory cleft to the olfactory groove. An endoscopic image (e) shows the tumor extending from the olfactory cleft to the middle meatus (arrowheads). MT: middle turbinate. Magnetic resonance images two years after operation show no recurrence of tumors (f)–(h).
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3368184&req=5

fig1: Preoperative computed tomography (a), and magnetic resonance images ((b) coronal, (c) sagittal, and (d) axial) show a cystic mass extending from the left olfactory cleft to the olfactory groove. An endoscopic image (e) shows the tumor extending from the olfactory cleft to the middle meatus (arrowheads). MT: middle turbinate. Magnetic resonance images two years after operation show no recurrence of tumors (f)–(h).
Mentions: Nasal endoscopy demonstrated a soft, whitish mass occupying the olfactory cleft and extending laterally to the middle meatus, with destruction of the middle turbinate in the left nostril. Computed tomography (CT) displayed a lesion at the olfactory cleft that extended superiorly to the olfactory groove, with a bone defect in the skull base (Figure 1(a)). The cribriform plate was elevated upward indicating that the tumor originated from the extracranial compartment. Magnetic resonance imaging (MRI) revealed a mass showing cystic changes (Figures 1(b)–1(d)), with solid portions demonstrating strong postgadolinium contrast enhancement. Our initial diagnosis based on radiographic findings was esthesioneuroblastoma. Partial resection of the tumor in the olfactory cleft was then performed using the endoscopic endonasal approach under local anesthesia, which suggested a histopathologic diagnosis of schwannoma. Based on this result, we planned subtotal resection of the tumor via an endoscopic endonasal approach.

Bottom Line: A female presented a large soft mass extending medially to the olfactory cleft and laterally to the middle meatus in the left nasal cavity.Imaging studies confirmed a cystic mass extending superiorly into the frontal lobe, indicating that the tumor arouse from the olfactory mucosa.Immunohistochemically constituent cells were diffusely positive for S-100 protein, but olfactory ensheathing cell tumor was diagnosed by negative staining for Leu7 (CD57).

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

ABSTRACT
We report a rare case of olfactory ensheathing cell tumor. A female presented a large soft mass extending medially to the olfactory cleft and laterally to the middle meatus in the left nasal cavity. Imaging studies confirmed a cystic mass extending superiorly into the frontal lobe, indicating that the tumor arouse from the olfactory mucosa. A subtotal resection was achieved through an endoscopic endonasal approach without operative complications. Immunohistochemically constituent cells were diffusely positive for S-100 protein, but olfactory ensheathing cell tumor was diagnosed by negative staining for Leu7 (CD57). This case indicates that olfactory ensheathing cell tumor should be included in differential diagnoses for the olfactory cleft tumors.

No MeSH data available.


Related in: MedlinePlus