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Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases.

Di Sano F, Piacentini M - Int J Cell Biol (2012)

Bottom Line: Reticulons (RTNs) are a group of membrane proteins localized on the ER and known to regulate ER structure and functions.Several studies have suggested that RTNs are involved in different important cellular functions such as changes in calcium homeostasis, ER-stress-mediated cell death, and autophagy.Reticulons have also been implicated in different signaling pathways which are at the basis of the pathogenesis of several neurodegenerative diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica, 00133 Rome, Italy.

ABSTRACT
Reticulons (RTNs) are a group of membrane proteins localized on the ER and known to regulate ER structure and functions. Several studies have suggested that RTNs are involved in different important cellular functions such as changes in calcium homeostasis, ER-stress-mediated cell death, and autophagy. RTNs have been demonstrated to exert a cancer specific proapoptotic function via the interaction or the modulation of specific proteins. Reticulons have also been implicated in different signaling pathways which are at the basis of the pathogenesis of several neurodegenerative diseases. In this paper we discuss the accumulating evidence identifying RTN-1C protein as a promising target in the treatment of different pathologies such as cancer or neurodegenerative disorders.

No MeSH data available.


Related in: MedlinePlus

Schematic representation of the different RTN-1C-induced signaling pathways. Modulation of RTN-1C expression triggers the ER stress pathway and the regulation of different proteins (green ovals) at different levels (blue boxes). These events affect cellular processes (red boxes) which are at the basis of several human pathological settings (grey boxes).
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fig2: Schematic representation of the different RTN-1C-induced signaling pathways. Modulation of RTN-1C expression triggers the ER stress pathway and the regulation of different proteins (green ovals) at different levels (blue boxes). These events affect cellular processes (red boxes) which are at the basis of several human pathological settings (grey boxes).

Mentions: Reticulons are expressed in most neuroendocrine tumors; they are considered to be highly sensitive and specific markers of neuroendocrine differentiation for use in the diagnosis. In this context it is interesting that reticulons can exert a cancer-specific proapoptotic function. Such evidence is particularly pertinent for the RTN-1C family member. The first experimental results in this regard detected RTN-1C capability of interacting with glucosylceramide synthase (GCS) (Figure 2), a key enzyme in the biosynthesis of glycosphingolipids, and implicated in many biological phenomena, including multidrug resistance (MDR) [37]. Various studies have demonstrated a direct correlation between the development of MDR and increased levels of glucosylceramide [37, 38], with GCS being suggested as a candidate target for cancer therapy.


Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases.

Di Sano F, Piacentini M - Int J Cell Biol (2012)

Schematic representation of the different RTN-1C-induced signaling pathways. Modulation of RTN-1C expression triggers the ER stress pathway and the regulation of different proteins (green ovals) at different levels (blue boxes). These events affect cellular processes (red boxes) which are at the basis of several human pathological settings (grey boxes).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368183&req=5

fig2: Schematic representation of the different RTN-1C-induced signaling pathways. Modulation of RTN-1C expression triggers the ER stress pathway and the regulation of different proteins (green ovals) at different levels (blue boxes). These events affect cellular processes (red boxes) which are at the basis of several human pathological settings (grey boxes).
Mentions: Reticulons are expressed in most neuroendocrine tumors; they are considered to be highly sensitive and specific markers of neuroendocrine differentiation for use in the diagnosis. In this context it is interesting that reticulons can exert a cancer-specific proapoptotic function. Such evidence is particularly pertinent for the RTN-1C family member. The first experimental results in this regard detected RTN-1C capability of interacting with glucosylceramide synthase (GCS) (Figure 2), a key enzyme in the biosynthesis of glycosphingolipids, and implicated in many biological phenomena, including multidrug resistance (MDR) [37]. Various studies have demonstrated a direct correlation between the development of MDR and increased levels of glucosylceramide [37, 38], with GCS being suggested as a candidate target for cancer therapy.

Bottom Line: Reticulons (RTNs) are a group of membrane proteins localized on the ER and known to regulate ER structure and functions.Several studies have suggested that RTNs are involved in different important cellular functions such as changes in calcium homeostasis, ER-stress-mediated cell death, and autophagy.Reticulons have also been implicated in different signaling pathways which are at the basis of the pathogenesis of several neurodegenerative diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica, 00133 Rome, Italy.

ABSTRACT
Reticulons (RTNs) are a group of membrane proteins localized on the ER and known to regulate ER structure and functions. Several studies have suggested that RTNs are involved in different important cellular functions such as changes in calcium homeostasis, ER-stress-mediated cell death, and autophagy. RTNs have been demonstrated to exert a cancer specific proapoptotic function via the interaction or the modulation of specific proteins. Reticulons have also been implicated in different signaling pathways which are at the basis of the pathogenesis of several neurodegenerative diseases. In this paper we discuss the accumulating evidence identifying RTN-1C protein as a promising target in the treatment of different pathologies such as cancer or neurodegenerative disorders.

No MeSH data available.


Related in: MedlinePlus