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Before It Gets Started: Regulating Translation at the 5' UTR.

Araujo PR, Yoon K, Ko D, Smith AD, Qiao M, Suresh U, Burns SC, Penalva LO - Comp. Funct. Genomics (2012)

Bottom Line: Translation regulation plays important roles in both normal physiological conditions and diseases states.This regulation requires cis-regulatory elements located mostly in 5' and 3' UTRs and trans-regulatory factors (e.g., RNA binding proteins (RBPs)) which recognize specific RNA features and interact with the translation machinery to modulate its activity.In this paper, we discuss important aspects of 5' UTR-mediated regulation by providing an overview of the characteristics and the function of the main elements present in this region, like uORF (upstream open reading frame), secondary structures, and RBPs binding motifs and different mechanisms of translation regulation and the impact they have on gene expression and human health when deregulated.

View Article: PubMed Central - PubMed

Affiliation: Greehey Children's Cancer Research Institute, UTHSCSA, San Antonio, TX 78229-3900, USA.

ABSTRACT
Translation regulation plays important roles in both normal physiological conditions and diseases states. This regulation requires cis-regulatory elements located mostly in 5' and 3' UTRs and trans-regulatory factors (e.g., RNA binding proteins (RBPs)) which recognize specific RNA features and interact with the translation machinery to modulate its activity. In this paper, we discuss important aspects of 5' UTR-mediated regulation by providing an overview of the characteristics and the function of the main elements present in this region, like uORF (upstream open reading frame), secondary structures, and RBPs binding motifs and different mechanisms of translation regulation and the impact they have on gene expression and human health when deregulated.

No MeSH data available.


Related in: MedlinePlus

Regulatory elements present in 5′ UTR.
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fig1: Regulatory elements present in 5′ UTR.

Mentions: In this paper, we will focus on the importance of 5′ UTR mediated regulation and the different functional elements present in this region with the exception of IRES which is discussed in a different article of this issue. The main regulatory elements in 5′ UTR are secondary structures (including IRES), binding sites for RNA binding proteins, uAUGs and uORFs (Figure 1).


Before It Gets Started: Regulating Translation at the 5' UTR.

Araujo PR, Yoon K, Ko D, Smith AD, Qiao M, Suresh U, Burns SC, Penalva LO - Comp. Funct. Genomics (2012)

Regulatory elements present in 5′ UTR.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3368165&req=5

fig1: Regulatory elements present in 5′ UTR.
Mentions: In this paper, we will focus on the importance of 5′ UTR mediated regulation and the different functional elements present in this region with the exception of IRES which is discussed in a different article of this issue. The main regulatory elements in 5′ UTR are secondary structures (including IRES), binding sites for RNA binding proteins, uAUGs and uORFs (Figure 1).

Bottom Line: Translation regulation plays important roles in both normal physiological conditions and diseases states.This regulation requires cis-regulatory elements located mostly in 5' and 3' UTRs and trans-regulatory factors (e.g., RNA binding proteins (RBPs)) which recognize specific RNA features and interact with the translation machinery to modulate its activity.In this paper, we discuss important aspects of 5' UTR-mediated regulation by providing an overview of the characteristics and the function of the main elements present in this region, like uORF (upstream open reading frame), secondary structures, and RBPs binding motifs and different mechanisms of translation regulation and the impact they have on gene expression and human health when deregulated.

View Article: PubMed Central - PubMed

Affiliation: Greehey Children's Cancer Research Institute, UTHSCSA, San Antonio, TX 78229-3900, USA.

ABSTRACT
Translation regulation plays important roles in both normal physiological conditions and diseases states. This regulation requires cis-regulatory elements located mostly in 5' and 3' UTRs and trans-regulatory factors (e.g., RNA binding proteins (RBPs)) which recognize specific RNA features and interact with the translation machinery to modulate its activity. In this paper, we discuss important aspects of 5' UTR-mediated regulation by providing an overview of the characteristics and the function of the main elements present in this region, like uORF (upstream open reading frame), secondary structures, and RBPs binding motifs and different mechanisms of translation regulation and the impact they have on gene expression and human health when deregulated.

No MeSH data available.


Related in: MedlinePlus