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Antimicrobial-drug susceptibility of human and animal Salmonella typhimurium, Minnesota, 1997-2003.

Wedel SD, Bender JB, Leano FT, Boxrud DJ, Hedberg C, Smith KE - Emerging Infect. Dis. (2005)

Bottom Line: Resistance to ceftriaxone and nalidixic acid increased, primarily among clonal group A/ACSSuT isolates.These data support the hypothesis that food animals are the primary reservoir of multidrug-resistant S.Typhimurium.

View Article: PubMed Central - PubMed

Affiliation: Acute Disease Investigation and Control Section, Minnesota Department of Health, Minneapolis, Minnesota 55164-0975, USA. stephanie.wedel@health.state.mn.us

ABSTRACT
We compared antimicrobial resistance phenotypes and pulsed-field gel electrophoresis (PFGE) subtypes of 1,028 human and 716 animal Salmonella enterica serotype Typhimurium isolates from Minnesota from 1997 to 2003. Overall, 29% of human isolates were multidrug resistant. Predominant phenotypes included resistance to ampicillin, chloramphenicol or kanamycin, streptomycin, sulfisoxazole, and tetracycline (ACSSuT or AKSSuT). Most human multidrug-resistant isolates belonged to PFGE clonal group A, characterized by ACSSuT resistance (64%), or clonal group B, characterized by AKSSuT resistance (19%). Most animal isolates were from cattle (n = 358) or swine (n = 251). Eighty-one percent were multidrug resistant; of these, 54% were at least resistance phenotype ACSSuT, and 43% were at least AKSSuT. More than 80% of multidrug-resistant isolates had a clonal group A or B subtype. Resistance to ceftriaxone and nalidixic acid increased, primarily among clonal group A/ACSSuT isolates. Clonal group B/AKSSuT isolates decreased over time. These data support the hypothesis that food animals are the primary reservoir of multidrug-resistant S. Typhimurium.

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Frequency of pulsed-field gel electrophoresis (PFGE) subtypes that occurred >15 times among clinical human or animal Salmonella enterica serovar Typhimurium isolates in Minnesota, 1997–2003. Subtypes TM5b, TM123, and TM218 are part of clonal group A (subtypes <3 bands different from subtype TM5b). Subtypes TM54, TM54a, and TM97 are part of clonal group B (subtypes <3 bands different from subtype TM54).
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Figure 4: Frequency of pulsed-field gel electrophoresis (PFGE) subtypes that occurred >15 times among clinical human or animal Salmonella enterica serovar Typhimurium isolates in Minnesota, 1997–2003. Subtypes TM5b, TM123, and TM218 are part of clonal group A (subtypes <3 bands different from subtype TM5b). Subtypes TM54, TM54a, and TM97 are part of clonal group B (subtypes <3 bands different from subtype TM54).

Mentions: Distribution of PFGE subtypes differed by species and year (Figures 2 and 4). CGB subtypes occurred predominantly in cattle and accounted for 67% of cattle isolates. As with AKSSuT isolates, CGB subtype isolates were numerous in cattle from 1997 to 1998, but the number dropped markedly in 2002 and 2003 (Figure 2). CGA subtype isolates increased in swine from 2000 to 2003 and substantially outnumbered CGA cattle isolates during those years. CGA isolates in cattle were most common from 1997 to 1998 and then declined to a relatively stable, low level (Figure 2).


Antimicrobial-drug susceptibility of human and animal Salmonella typhimurium, Minnesota, 1997-2003.

Wedel SD, Bender JB, Leano FT, Boxrud DJ, Hedberg C, Smith KE - Emerging Infect. Dis. (2005)

Frequency of pulsed-field gel electrophoresis (PFGE) subtypes that occurred >15 times among clinical human or animal Salmonella enterica serovar Typhimurium isolates in Minnesota, 1997–2003. Subtypes TM5b, TM123, and TM218 are part of clonal group A (subtypes <3 bands different from subtype TM5b). Subtypes TM54, TM54a, and TM97 are part of clonal group B (subtypes <3 bands different from subtype TM54).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3367623&req=5

Figure 4: Frequency of pulsed-field gel electrophoresis (PFGE) subtypes that occurred >15 times among clinical human or animal Salmonella enterica serovar Typhimurium isolates in Minnesota, 1997–2003. Subtypes TM5b, TM123, and TM218 are part of clonal group A (subtypes <3 bands different from subtype TM5b). Subtypes TM54, TM54a, and TM97 are part of clonal group B (subtypes <3 bands different from subtype TM54).
Mentions: Distribution of PFGE subtypes differed by species and year (Figures 2 and 4). CGB subtypes occurred predominantly in cattle and accounted for 67% of cattle isolates. As with AKSSuT isolates, CGB subtype isolates were numerous in cattle from 1997 to 1998, but the number dropped markedly in 2002 and 2003 (Figure 2). CGA subtype isolates increased in swine from 2000 to 2003 and substantially outnumbered CGA cattle isolates during those years. CGA isolates in cattle were most common from 1997 to 1998 and then declined to a relatively stable, low level (Figure 2).

Bottom Line: Resistance to ceftriaxone and nalidixic acid increased, primarily among clonal group A/ACSSuT isolates.These data support the hypothesis that food animals are the primary reservoir of multidrug-resistant S.Typhimurium.

View Article: PubMed Central - PubMed

Affiliation: Acute Disease Investigation and Control Section, Minnesota Department of Health, Minneapolis, Minnesota 55164-0975, USA. stephanie.wedel@health.state.mn.us

ABSTRACT
We compared antimicrobial resistance phenotypes and pulsed-field gel electrophoresis (PFGE) subtypes of 1,028 human and 716 animal Salmonella enterica serotype Typhimurium isolates from Minnesota from 1997 to 2003. Overall, 29% of human isolates were multidrug resistant. Predominant phenotypes included resistance to ampicillin, chloramphenicol or kanamycin, streptomycin, sulfisoxazole, and tetracycline (ACSSuT or AKSSuT). Most human multidrug-resistant isolates belonged to PFGE clonal group A, characterized by ACSSuT resistance (64%), or clonal group B, characterized by AKSSuT resistance (19%). Most animal isolates were from cattle (n = 358) or swine (n = 251). Eighty-one percent were multidrug resistant; of these, 54% were at least resistance phenotype ACSSuT, and 43% were at least AKSSuT. More than 80% of multidrug-resistant isolates had a clonal group A or B subtype. Resistance to ceftriaxone and nalidixic acid increased, primarily among clonal group A/ACSSuT isolates. Clonal group B/AKSSuT isolates decreased over time. These data support the hypothesis that food animals are the primary reservoir of multidrug-resistant S. Typhimurium.

Show MeSH
Related in: MedlinePlus