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Viral load distribution in SARS outbreak.

Chu CM, Cheng VC, Hung IF, Chan KS, Tang BS, Tsang TH, Chan KH, Yuen KY - Emerging Infect. Dis. (2005)

Bottom Line: Higher nasopharyngeal viral load was found in patients living in adjacent units of the same block inhabited by the index patient, while a lower but detectable nasopharyngeal viral load was found in patients living further away from the index patient.This pattern of nasopharyngeal viral load suggested that airborne transmission played an important part in this outbreak in Hong Kong.Contaminated fomites and rodent pests may have also played a role.

View Article: PubMed Central - PubMed

Affiliation: United Christian Hospital, Hong Kong Special Administrative Region, People's Republic of China.

ABSTRACT
An unprecedented community outbreak of severe acute respiratory syndrome (SARS) occurred in the Amoy Gardens, a high-rise residential complex in Hong Kong. Droplet, air, contaminated fomites, and rodent pests have been proposed to be mechanisms for transmitting SARS in a short period. We studied nasopharyngeal viral load of SARS patients on admission and their geographic distribution. Higher nasopharyngeal viral load was found in patients living in adjacent units of the same block inhabited by the index patient, while a lower but detectable nasopharyngeal viral load was found in patients living further away from the index patient. This pattern of nasopharyngeal viral load suggested that airborne transmission played an important part in this outbreak in Hong Kong. Contaminated fomites and rodent pests may have also played a role.

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Related in: MedlinePlus

Distribution of viral load in nasopharyngeal specimens (log10 copies/mL) of Amoy Gardens residents in E7 (A) and E8 (B).
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Related In: Results  -  Collection


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Figure 3: Distribution of viral load in nasopharyngeal specimens (log10 copies/mL) of Amoy Gardens residents in E7 (A) and E8 (B).

Mentions: The relationships between viral load and distribution of patients from E7 and E8 are shown in Figure 3A and B, respectively. In E7, patients who resided within a few stories of the 16th floor had higher viral loads. For cases in neighboring E8, the distribution of patients and viral loads was random.


Viral load distribution in SARS outbreak.

Chu CM, Cheng VC, Hung IF, Chan KS, Tang BS, Tsang TH, Chan KH, Yuen KY - Emerging Infect. Dis. (2005)

Distribution of viral load in nasopharyngeal specimens (log10 copies/mL) of Amoy Gardens residents in E7 (A) and E8 (B).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3367618&req=5

Figure 3: Distribution of viral load in nasopharyngeal specimens (log10 copies/mL) of Amoy Gardens residents in E7 (A) and E8 (B).
Mentions: The relationships between viral load and distribution of patients from E7 and E8 are shown in Figure 3A and B, respectively. In E7, patients who resided within a few stories of the 16th floor had higher viral loads. For cases in neighboring E8, the distribution of patients and viral loads was random.

Bottom Line: Higher nasopharyngeal viral load was found in patients living in adjacent units of the same block inhabited by the index patient, while a lower but detectable nasopharyngeal viral load was found in patients living further away from the index patient.This pattern of nasopharyngeal viral load suggested that airborne transmission played an important part in this outbreak in Hong Kong.Contaminated fomites and rodent pests may have also played a role.

View Article: PubMed Central - PubMed

Affiliation: United Christian Hospital, Hong Kong Special Administrative Region, People's Republic of China.

ABSTRACT
An unprecedented community outbreak of severe acute respiratory syndrome (SARS) occurred in the Amoy Gardens, a high-rise residential complex in Hong Kong. Droplet, air, contaminated fomites, and rodent pests have been proposed to be mechanisms for transmitting SARS in a short period. We studied nasopharyngeal viral load of SARS patients on admission and their geographic distribution. Higher nasopharyngeal viral load was found in patients living in adjacent units of the same block inhabited by the index patient, while a lower but detectable nasopharyngeal viral load was found in patients living further away from the index patient. This pattern of nasopharyngeal viral load suggested that airborne transmission played an important part in this outbreak in Hong Kong. Contaminated fomites and rodent pests may have also played a role.

Show MeSH
Related in: MedlinePlus