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Integrating Escherichia coli antimicrobial susceptibility data from multiple surveillance programs.

Stelling JM, Travers K, Jones RN, Turner PJ, O'Brien TF, Levy SB - Emerging Infect. Dis. (2005)

Bottom Line: For most antimicrobial drugs considered, nonsusceptibility was higher in isolates from men, older patients, and intensive care unit patients.Nonsusceptibility to ciprofloxacin was higher in younger patients, rose with time, and was not associated with intensive care unit status.In univariate analyses, estimates of nonsusceptibility from MYSTIC were consistently higher than those from SENTRY, but these differences disappeared in multivariate analyses, which supports the epidemiologic relevance of findings from the 2 programs, despite differences in surveillance strategies.

View Article: PubMed Central - PubMed

Affiliation: Alliance for the Prudent Use of Antibiotics, Boston, Massachusetts 02115, USA. jstelling@rics.bwh.harvard.edu

ABSTRACT
Collaboration between networks presents opportunities to increase analytical power and cross-validate findings. Multivariate analyses of 2 large, international datasets (MYSTIC and SENTRY) from the Global Advisory on Antibiotic Resistance Data program explored temporal, geographic, and demographic trends in Escherichia coli resistance from 1997 to 2001. Elevated rates of nonsusceptibility were seen in Latin America, southern Europe, and the western Pacific, and lower rates were seen in North America. For most antimicrobial drugs considered, nonsusceptibility was higher in isolates from men, older patients, and intensive care unit patients. Nonsusceptibility to ciprofloxacin was higher in younger patients, rose with time, and was not associated with intensive care unit status. In univariate analyses, estimates of nonsusceptibility from MYSTIC were consistently higher than those from SENTRY, but these differences disappeared in multivariate analyses, which supports the epidemiologic relevance of findings from the 2 programs, despite differences in surveillance strategies.

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MYSTIC results for comparison countries. Annual nonsusceptibility rates of Escherichia coli isolates, 1997–2001. p<0.05. CAZ, ceftazidime; TZP, piperacillin/tazobactam; GEN, gentamicin; CIP, ciprofloxacin; TOB, tobramycin; FEP, cefepime.
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Figure 2: MYSTIC results for comparison countries. Annual nonsusceptibility rates of Escherichia coli isolates, 1997–2001. p<0.05. CAZ, ceftazidime; TZP, piperacillin/tazobactam; GEN, gentamicin; CIP, ciprofloxacin; TOB, tobramycin; FEP, cefepime.

Mentions: Temporal trends from several of the comparison countries are shown in Figures 2, Figure 3, and 4. With the exception of ciprofloxacin, the antimicrobial drugs tested by both systems are principally reserved for intravenous use in hospitalized patients in most countries, and nonsusceptibility rates for these second-line agents were low worldwide, with some exceptions. Countries with nonsusceptibility rates ≥20% to at least 3 of the core agents by at least 1 of the systems in 2000 or 2001 include Israel, Poland, Mexico, Venezuela, Hong Kong, and the Philippines.


Integrating Escherichia coli antimicrobial susceptibility data from multiple surveillance programs.

Stelling JM, Travers K, Jones RN, Turner PJ, O'Brien TF, Levy SB - Emerging Infect. Dis. (2005)

MYSTIC results for comparison countries. Annual nonsusceptibility rates of Escherichia coli isolates, 1997–2001. p<0.05. CAZ, ceftazidime; TZP, piperacillin/tazobactam; GEN, gentamicin; CIP, ciprofloxacin; TOB, tobramycin; FEP, cefepime.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3367601&req=5

Figure 2: MYSTIC results for comparison countries. Annual nonsusceptibility rates of Escherichia coli isolates, 1997–2001. p<0.05. CAZ, ceftazidime; TZP, piperacillin/tazobactam; GEN, gentamicin; CIP, ciprofloxacin; TOB, tobramycin; FEP, cefepime.
Mentions: Temporal trends from several of the comparison countries are shown in Figures 2, Figure 3, and 4. With the exception of ciprofloxacin, the antimicrobial drugs tested by both systems are principally reserved for intravenous use in hospitalized patients in most countries, and nonsusceptibility rates for these second-line agents were low worldwide, with some exceptions. Countries with nonsusceptibility rates ≥20% to at least 3 of the core agents by at least 1 of the systems in 2000 or 2001 include Israel, Poland, Mexico, Venezuela, Hong Kong, and the Philippines.

Bottom Line: For most antimicrobial drugs considered, nonsusceptibility was higher in isolates from men, older patients, and intensive care unit patients.Nonsusceptibility to ciprofloxacin was higher in younger patients, rose with time, and was not associated with intensive care unit status.In univariate analyses, estimates of nonsusceptibility from MYSTIC were consistently higher than those from SENTRY, but these differences disappeared in multivariate analyses, which supports the epidemiologic relevance of findings from the 2 programs, despite differences in surveillance strategies.

View Article: PubMed Central - PubMed

Affiliation: Alliance for the Prudent Use of Antibiotics, Boston, Massachusetts 02115, USA. jstelling@rics.bwh.harvard.edu

ABSTRACT
Collaboration between networks presents opportunities to increase analytical power and cross-validate findings. Multivariate analyses of 2 large, international datasets (MYSTIC and SENTRY) from the Global Advisory on Antibiotic Resistance Data program explored temporal, geographic, and demographic trends in Escherichia coli resistance from 1997 to 2001. Elevated rates of nonsusceptibility were seen in Latin America, southern Europe, and the western Pacific, and lower rates were seen in North America. For most antimicrobial drugs considered, nonsusceptibility was higher in isolates from men, older patients, and intensive care unit patients. Nonsusceptibility to ciprofloxacin was higher in younger patients, rose with time, and was not associated with intensive care unit status. In univariate analyses, estimates of nonsusceptibility from MYSTIC were consistently higher than those from SENTRY, but these differences disappeared in multivariate analyses, which supports the epidemiologic relevance of findings from the 2 programs, despite differences in surveillance strategies.

Show MeSH
Related in: MedlinePlus