Limits...
Erythromycin-nonsusceptible Streptococcus pneumoniae in children, 1999-2001.

McEllistrem MC, Adams JM, Shutt K, Sanza LT, Facklam RR, Whitney CG, Jorgensen JH, Harrison LH - Emerging Infect. Dis. (2005)

Bottom Line: After increasing from 1995 to 1999, invasive erythromycin-nonsusceptible Streptococcus pneumoniae rates per 100,000 decreased 53.6% in children from Baltimore, Maryland (US), from 1999 to 2001, which was partially attributed to strains related to the mefE-carrying England14-9 clone.The decline in infection rates was likely due to the pneumococcal 7-valent conjugate vaccine.

View Article: PubMed Central - PubMed

Affiliation: University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15213-2582, USA. mcellistremc@msx.dept-med.pitt.edu

ABSTRACT
After increasing from 1995 to 1999, invasive erythromycin-nonsusceptible Streptococcus pneumoniae rates per 100,000 decreased 53.6% in children from Baltimore, Maryland (US), from 1999 to 2001, which was partially attributed to strains related to the mefE-carrying England14-9 clone. The decline in infection rates was likely due to the pneumococcal 7-valent conjugate vaccine.

Show MeSH

Related in: MedlinePlus

From 1995 to 2001, the proportion of erythromycin-nonsusceptible pneumococcal strains carrying the mefE gene increased over time by county, season, race, and age group. p<0.01 for all trends except for Anne Arundel County and May–October season (p = 0.02 for those comparisons).
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3367581&req=5

Figure 1: From 1995 to 2001, the proportion of erythromycin-nonsusceptible pneumococcal strains carrying the mefE gene increased over time by county, season, race, and age group. p<0.01 for all trends except for Anne Arundel County and May–October season (p = 0.02 for those comparisons).

Mentions: The incidence of invasive pneumococcal disease significantly increased from 1995 to 1999 before dramatically decreasing from 1999 to 2001. From 1995 to 1999, the overall rates of erythromycin-nonsusceptible S. pneumoniae and mefE-associated disease increased, and then stabilized from 1999 to 2001 (Table). While the overall rates of erythromycin-nonsusceptible S. pneumoniae were stable, the proportion of pneumococcal strains with reduced susceptibility to erythromycin increased from 5.1% (26/510) in 1995 to 13.6% (77/567) in 2001 (p<0.01). Moreover, the proportion of erythromycin-nonsusceptible S. pneumoniae strains carrying the mefE gene with an erythromycin MIC ≥16 μg/mL increased from 0% (0/12) in 1995 to 12.3% (8/65) in 2001 (χ2 for linear trend, p = 0.02). The proportion of erythromycin-nonsusceptible S. pneumoniae strains carrying the mefE gene increased from 48.0% (12/25) in 1995 to 85.5% (65/76) in 2001 (p<0.01). Of the erythromycin-nonsusceptible S. pneumoniae strains, the proportion of mefE-carrying strains that were penicillin-nonsusceptible S. pneumoniae rose from 20.0% (5/25) in 1995 to 72.4% (55/76) in 2001 (p<0.01). In 3 counties, in both age groups, in both races, and during both seasons, the proportion of mefE-carrying strains increased from 1995 to 2001 (Figure; p values for all analyses were ≤0.02). Sixty-nine percent (182/263) of the mefE-carrying strains were related to 4 international clones (percent serotype): 30.0% England14-9 clone (100% 14); 16.0% Spain23F-1 clone (83.3% 23F); 14.1% Spain9V-3 clone (97.3% 9V); and 9.1% Taiwan19F-14 clone (95.8% 19F).


Erythromycin-nonsusceptible Streptococcus pneumoniae in children, 1999-2001.

McEllistrem MC, Adams JM, Shutt K, Sanza LT, Facklam RR, Whitney CG, Jorgensen JH, Harrison LH - Emerging Infect. Dis. (2005)

From 1995 to 2001, the proportion of erythromycin-nonsusceptible pneumococcal strains carrying the mefE gene increased over time by county, season, race, and age group. p<0.01 for all trends except for Anne Arundel County and May–October season (p = 0.02 for those comparisons).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3367581&req=5

Figure 1: From 1995 to 2001, the proportion of erythromycin-nonsusceptible pneumococcal strains carrying the mefE gene increased over time by county, season, race, and age group. p<0.01 for all trends except for Anne Arundel County and May–October season (p = 0.02 for those comparisons).
Mentions: The incidence of invasive pneumococcal disease significantly increased from 1995 to 1999 before dramatically decreasing from 1999 to 2001. From 1995 to 1999, the overall rates of erythromycin-nonsusceptible S. pneumoniae and mefE-associated disease increased, and then stabilized from 1999 to 2001 (Table). While the overall rates of erythromycin-nonsusceptible S. pneumoniae were stable, the proportion of pneumococcal strains with reduced susceptibility to erythromycin increased from 5.1% (26/510) in 1995 to 13.6% (77/567) in 2001 (p<0.01). Moreover, the proportion of erythromycin-nonsusceptible S. pneumoniae strains carrying the mefE gene with an erythromycin MIC ≥16 μg/mL increased from 0% (0/12) in 1995 to 12.3% (8/65) in 2001 (χ2 for linear trend, p = 0.02). The proportion of erythromycin-nonsusceptible S. pneumoniae strains carrying the mefE gene increased from 48.0% (12/25) in 1995 to 85.5% (65/76) in 2001 (p<0.01). Of the erythromycin-nonsusceptible S. pneumoniae strains, the proportion of mefE-carrying strains that were penicillin-nonsusceptible S. pneumoniae rose from 20.0% (5/25) in 1995 to 72.4% (55/76) in 2001 (p<0.01). In 3 counties, in both age groups, in both races, and during both seasons, the proportion of mefE-carrying strains increased from 1995 to 2001 (Figure; p values for all analyses were ≤0.02). Sixty-nine percent (182/263) of the mefE-carrying strains were related to 4 international clones (percent serotype): 30.0% England14-9 clone (100% 14); 16.0% Spain23F-1 clone (83.3% 23F); 14.1% Spain9V-3 clone (97.3% 9V); and 9.1% Taiwan19F-14 clone (95.8% 19F).

Bottom Line: After increasing from 1995 to 1999, invasive erythromycin-nonsusceptible Streptococcus pneumoniae rates per 100,000 decreased 53.6% in children from Baltimore, Maryland (US), from 1999 to 2001, which was partially attributed to strains related to the mefE-carrying England14-9 clone.The decline in infection rates was likely due to the pneumococcal 7-valent conjugate vaccine.

View Article: PubMed Central - PubMed

Affiliation: University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15213-2582, USA. mcellistremc@msx.dept-med.pitt.edu

ABSTRACT
After increasing from 1995 to 1999, invasive erythromycin-nonsusceptible Streptococcus pneumoniae rates per 100,000 decreased 53.6% in children from Baltimore, Maryland (US), from 1999 to 2001, which was partially attributed to strains related to the mefE-carrying England14-9 clone. The decline in infection rates was likely due to the pneumococcal 7-valent conjugate vaccine.

Show MeSH
Related in: MedlinePlus