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Community-associated methicillin-resistant Staphylococcus aureus, Switzerland.

Harbarth S, Fran├žois P, Shrenzel J, Fankhauser-Rodriguez C, Hugonnet S, Koessler T, Huyghe A, Pittet D - Emerging Infect. Dis. (2005)

Bottom Line: Among 14,253 patients, CA-MRSA prevalence was 0.9/1,000 admissions.Although 5 CA-MRSA isolates contained Panton-Valentine leukocidin, only 1 patient had a previous skin infection.No easily modifiable risk factor for CA-MRSA was identified.

View Article: PubMed Central - PubMed

Affiliation: University of Geneva Hospitals, Geneva, Switzerland. stephan.harbarth@hcuge.ch

ABSTRACT
Two case-control studies evaluated the prevalence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) carriage at hospital admission and characteristics of patients with CA-MRSA. Among 14,253 patients, CA-MRSA prevalence was 0.9/1,000 admissions. Although 5 CA-MRSA isolates contained Panton-Valentine leukocidin, only 1 patient had a previous skin infection. No easily modifiable risk factor for CA-MRSA was identified.

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Analysis of genotyping patterns, multilocus sequence typing (ST) results, presence of Panton-Valentine leukocidin (PVL), staphylococcal cassette chromosome mec (SCCmec) type, and country of patient origin of 13 community-associated, methicillin-resistant Staphylococcus aureus isolates (CA-MRSA). The dendrogram illustrates the genetic relatedness of the 13 CA-MRSA in comparison to 1) 2 nosocomial MRSA isolates representing the prevailing endemic strain in the Geneva healthcare setting (strains B5-63, B5-64) and to 2) profiles obtained for strains MW2 and HT20030642 from the United States, 2 closely related CA-MRSA isolates used as controls.
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Figure 1: Analysis of genotyping patterns, multilocus sequence typing (ST) results, presence of Panton-Valentine leukocidin (PVL), staphylococcal cassette chromosome mec (SCCmec) type, and country of patient origin of 13 community-associated, methicillin-resistant Staphylococcus aureus isolates (CA-MRSA). The dendrogram illustrates the genetic relatedness of the 13 CA-MRSA in comparison to 1) 2 nosocomial MRSA isolates representing the prevailing endemic strain in the Geneva healthcare setting (strains B5-63, B5-64) and to 2) profiles obtained for strains MW2 and HT20030642 from the United States, 2 closely related CA-MRSA isolates used as controls.

Mentions: Ten CA-MRSA isolates harbored the SCCmec type IV, 2 the type V, and 1 the type II element (Figure). All CA-MRSA isolates were susceptible to trimethoprim-sulfamethoxazole, clindamycin, and vancomycin. Two isolates (SCCmec type V) were resistant to gentamicin; 2 other isolates (SCCmec type IV) showed resistance to fluoroquinolones; and 1 (SCCmec type II) was resistant to macrolides. Although 5 (38%) of 13 CA-MRSA isolates possessed the pvl gene, only 1 patient had a skin infection on admission. The other 4 patients had no history of infection.


Community-associated methicillin-resistant Staphylococcus aureus, Switzerland.

Harbarth S, Fran├žois P, Shrenzel J, Fankhauser-Rodriguez C, Hugonnet S, Koessler T, Huyghe A, Pittet D - Emerging Infect. Dis. (2005)

Analysis of genotyping patterns, multilocus sequence typing (ST) results, presence of Panton-Valentine leukocidin (PVL), staphylococcal cassette chromosome mec (SCCmec) type, and country of patient origin of 13 community-associated, methicillin-resistant Staphylococcus aureus isolates (CA-MRSA). The dendrogram illustrates the genetic relatedness of the 13 CA-MRSA in comparison to 1) 2 nosocomial MRSA isolates representing the prevailing endemic strain in the Geneva healthcare setting (strains B5-63, B5-64) and to 2) profiles obtained for strains MW2 and HT20030642 from the United States, 2 closely related CA-MRSA isolates used as controls.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3367580&req=5

Figure 1: Analysis of genotyping patterns, multilocus sequence typing (ST) results, presence of Panton-Valentine leukocidin (PVL), staphylococcal cassette chromosome mec (SCCmec) type, and country of patient origin of 13 community-associated, methicillin-resistant Staphylococcus aureus isolates (CA-MRSA). The dendrogram illustrates the genetic relatedness of the 13 CA-MRSA in comparison to 1) 2 nosocomial MRSA isolates representing the prevailing endemic strain in the Geneva healthcare setting (strains B5-63, B5-64) and to 2) profiles obtained for strains MW2 and HT20030642 from the United States, 2 closely related CA-MRSA isolates used as controls.
Mentions: Ten CA-MRSA isolates harbored the SCCmec type IV, 2 the type V, and 1 the type II element (Figure). All CA-MRSA isolates were susceptible to trimethoprim-sulfamethoxazole, clindamycin, and vancomycin. Two isolates (SCCmec type V) were resistant to gentamicin; 2 other isolates (SCCmec type IV) showed resistance to fluoroquinolones; and 1 (SCCmec type II) was resistant to macrolides. Although 5 (38%) of 13 CA-MRSA isolates possessed the pvl gene, only 1 patient had a skin infection on admission. The other 4 patients had no history of infection.

Bottom Line: Among 14,253 patients, CA-MRSA prevalence was 0.9/1,000 admissions.Although 5 CA-MRSA isolates contained Panton-Valentine leukocidin, only 1 patient had a previous skin infection.No easily modifiable risk factor for CA-MRSA was identified.

View Article: PubMed Central - PubMed

Affiliation: University of Geneva Hospitals, Geneva, Switzerland. stephan.harbarth@hcuge.ch

ABSTRACT
Two case-control studies evaluated the prevalence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) carriage at hospital admission and characteristics of patients with CA-MRSA. Among 14,253 patients, CA-MRSA prevalence was 0.9/1,000 admissions. Although 5 CA-MRSA isolates contained Panton-Valentine leukocidin, only 1 patient had a previous skin infection. No easily modifiable risk factor for CA-MRSA was identified.

Show MeSH
Related in: MedlinePlus