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Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair.

Su J, Cao L, Yu B, Song S, Liu X, Wang Z, Li M - Int J Nanomedicine (2012)

Bottom Line: The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%.The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds.The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China. sujiacan2012@yahoo.cn

ABSTRACT
A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

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Macroscopic evaluation of mesoporous bioactive glass and polyamide composite scaffolds implanted into bone defects of rabbit femora for (A) 4 weeks and (B) 12 weeks.Note: Circle and arrow show the bone defect area site.
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f7-ijn-7-2547: Macroscopic evaluation of mesoporous bioactive glass and polyamide composite scaffolds implanted into bone defects of rabbit femora for (A) 4 weeks and (B) 12 weeks.Note: Circle and arrow show the bone defect area site.

Mentions: Figure 7 shows the macroscopic evaluation of the m-BPC scaffolds implanted in the bone cavities of rabbit femora for 4 weeks and 12 weeks. At 4 weeks, abscission of the suture occurred and the surface of the bone defects was partially filled with callus bone. At 12 weeks, the bone defects were repaired by implanted scaffolds; the wounds healed well without dehiscence and did not elicit any obvious inflammatory response in the adjacent soft tissue. No signs of implant rejection, necrosis, or infection were found at the experimental time.


Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair.

Su J, Cao L, Yu B, Song S, Liu X, Wang Z, Li M - Int J Nanomedicine (2012)

Macroscopic evaluation of mesoporous bioactive glass and polyamide composite scaffolds implanted into bone defects of rabbit femora for (A) 4 weeks and (B) 12 weeks.Note: Circle and arrow show the bone defect area site.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3367494&req=5

f7-ijn-7-2547: Macroscopic evaluation of mesoporous bioactive glass and polyamide composite scaffolds implanted into bone defects of rabbit femora for (A) 4 weeks and (B) 12 weeks.Note: Circle and arrow show the bone defect area site.
Mentions: Figure 7 shows the macroscopic evaluation of the m-BPC scaffolds implanted in the bone cavities of rabbit femora for 4 weeks and 12 weeks. At 4 weeks, abscission of the suture occurred and the surface of the bone defects was partially filled with callus bone. At 12 weeks, the bone defects were repaired by implanted scaffolds; the wounds healed well without dehiscence and did not elicit any obvious inflammatory response in the adjacent soft tissue. No signs of implant rejection, necrosis, or infection were found at the experimental time.

Bottom Line: The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%.The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds.The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China. sujiacan2012@yahoo.cn

ABSTRACT
A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

Show MeSH