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Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair.

Su J, Cao L, Yu B, Song S, Liu X, Wang Z, Li M - Int J Nanomedicine (2012)

Bottom Line: The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%.The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds.The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China. sujiacan2012@yahoo.cn

ABSTRACT
A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

Show MeSH
Phase contrast microscopic photographs of MG-63 cells cultured with (A) mesoporous bioactive glass and polyamide composite scaffolds and (B) and polyamide scaffolds for 4 hours.
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f6-ijn-7-2547: Phase contrast microscopic photographs of MG-63 cells cultured with (A) mesoporous bioactive glass and polyamide composite scaffolds and (B) and polyamide scaffolds for 4 hours.

Mentions: Morphologies of MG-63 cells cultured with m-BPC and PA scaffold samples were observed using phase contrast microscopy, as shown in Figure 6. The micrographs reveal that after being cultured for 4 hours, MG-63 cells cultured with both m-BPC and PA specimens grew well and stretched sufficiently, had full configurations, and showed no abnormal morphologies. These results indicate that both m-BPC and PA scaffolds had no negative effect on MG-63 cell morphology and viability, and both provide good cytocompatibility.


Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair.

Su J, Cao L, Yu B, Song S, Liu X, Wang Z, Li M - Int J Nanomedicine (2012)

Phase contrast microscopic photographs of MG-63 cells cultured with (A) mesoporous bioactive glass and polyamide composite scaffolds and (B) and polyamide scaffolds for 4 hours.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3367494&req=5

f6-ijn-7-2547: Phase contrast microscopic photographs of MG-63 cells cultured with (A) mesoporous bioactive glass and polyamide composite scaffolds and (B) and polyamide scaffolds for 4 hours.
Mentions: Morphologies of MG-63 cells cultured with m-BPC and PA scaffold samples were observed using phase contrast microscopy, as shown in Figure 6. The micrographs reveal that after being cultured for 4 hours, MG-63 cells cultured with both m-BPC and PA specimens grew well and stretched sufficiently, had full configurations, and showed no abnormal morphologies. These results indicate that both m-BPC and PA scaffolds had no negative effect on MG-63 cell morphology and viability, and both provide good cytocompatibility.

Bottom Line: The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%.The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds.The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China. sujiacan2012@yahoo.cn

ABSTRACT
A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

Show MeSH