Limits...
Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair.

Su J, Cao L, Yu B, Song S, Liu X, Wang Z, Li M - Int J Nanomedicine (2012)

Bottom Line: The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%.The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds.The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China. sujiacan2012@yahoo.cn

ABSTRACT
A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

Show MeSH
Attachment of MG-63 cells on mesoporous bioactive glass and polyamide composite scaffolds. Polyamide scaffolds and tissue culture plate were used as controls. Cell attachment is compared to the tissue culture plate control (100%).Notes: *Statistical analysis: cell attachment ratio for m-BPC were significantly higher than PA and the control (P < 0.05)Abbreviations: m-BPC, mesoporous bioactive glass and polyamide composite; PA6, polyamide 6; TCP, tissue culture plate.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3367494&req=5

f5-ijn-7-2547: Attachment of MG-63 cells on mesoporous bioactive glass and polyamide composite scaffolds. Polyamide scaffolds and tissue culture plate were used as controls. Cell attachment is compared to the tissue culture plate control (100%).Notes: *Statistical analysis: cell attachment ratio for m-BPC were significantly higher than PA and the control (P < 0.05)Abbreviations: m-BPC, mesoporous bioactive glass and polyamide composite; PA6, polyamide 6; TCP, tissue culture plate.

Mentions: Cell attachment was investigated using the MTT assay of MG-63 cells cultured on m-BPC scaffold samples; PA scaffolds and tissue culture plate were used as controls. Figure 5 shows the results of the optical density values (represents cell attachment ratio) for these scaffold samples. At 4 hours, the optical density values for m-BPC were significantly higher than PA and the control (P < 0.05). These results indicate that cell attachment for m-BPC was superior to PA samples, suggesting that m-BPC facilitated cell adhesion on its surfaces.


Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair.

Su J, Cao L, Yu B, Song S, Liu X, Wang Z, Li M - Int J Nanomedicine (2012)

Attachment of MG-63 cells on mesoporous bioactive glass and polyamide composite scaffolds. Polyamide scaffolds and tissue culture plate were used as controls. Cell attachment is compared to the tissue culture plate control (100%).Notes: *Statistical analysis: cell attachment ratio for m-BPC were significantly higher than PA and the control (P < 0.05)Abbreviations: m-BPC, mesoporous bioactive glass and polyamide composite; PA6, polyamide 6; TCP, tissue culture plate.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3367494&req=5

f5-ijn-7-2547: Attachment of MG-63 cells on mesoporous bioactive glass and polyamide composite scaffolds. Polyamide scaffolds and tissue culture plate were used as controls. Cell attachment is compared to the tissue culture plate control (100%).Notes: *Statistical analysis: cell attachment ratio for m-BPC were significantly higher than PA and the control (P < 0.05)Abbreviations: m-BPC, mesoporous bioactive glass and polyamide composite; PA6, polyamide 6; TCP, tissue culture plate.
Mentions: Cell attachment was investigated using the MTT assay of MG-63 cells cultured on m-BPC scaffold samples; PA scaffolds and tissue culture plate were used as controls. Figure 5 shows the results of the optical density values (represents cell attachment ratio) for these scaffold samples. At 4 hours, the optical density values for m-BPC were significantly higher than PA and the control (P < 0.05). These results indicate that cell attachment for m-BPC was superior to PA samples, suggesting that m-BPC facilitated cell adhesion on its surfaces.

Bottom Line: The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%.The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds.The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China. sujiacan2012@yahoo.cn

ABSTRACT
A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

Show MeSH