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Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair.

Su J, Cao L, Yu B, Song S, Liu X, Wang Z, Li M - Int J Nanomedicine (2012)

Bottom Line: The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%.The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds.The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China. sujiacan2012@yahoo.cn

ABSTRACT
A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

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Photo of mesoporous bioactive glass and polyamide composite scaffolds.
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f3-ijn-7-2547: Photo of mesoporous bioactive glass and polyamide composite scaffolds.

Mentions: Figure 3 shows a photo of m-BPC scaffolds. Figure 4 shows the SEM images of the surface morphology and microstructure of the m-BPC porous scaffolds under various magnifications. The m-BPC scaffolds exhibited a macroporous structure with completely open interconnected pores. The pores appeared almost spherical in shape, with diameters of 400–500 μm (Figure 4A). High-magnification SEM images further revealed that a number of small pores (around 2 μm) were distributed across the macropore walls. The porosity of the m-BPC scaffolds prepared by this method was around 76%.


Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair.

Su J, Cao L, Yu B, Song S, Liu X, Wang Z, Li M - Int J Nanomedicine (2012)

Photo of mesoporous bioactive glass and polyamide composite scaffolds.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3367494&req=5

f3-ijn-7-2547: Photo of mesoporous bioactive glass and polyamide composite scaffolds.
Mentions: Figure 3 shows a photo of m-BPC scaffolds. Figure 4 shows the SEM images of the surface morphology and microstructure of the m-BPC porous scaffolds under various magnifications. The m-BPC scaffolds exhibited a macroporous structure with completely open interconnected pores. The pores appeared almost spherical in shape, with diameters of 400–500 μm (Figure 4A). High-magnification SEM images further revealed that a number of small pores (around 2 μm) were distributed across the macropore walls. The porosity of the m-BPC scaffolds prepared by this method was around 76%.

Bottom Line: The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%.The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds.The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China. sujiacan2012@yahoo.cn

ABSTRACT
A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

Show MeSH