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Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair.

Su J, Cao L, Yu B, Song S, Liu X, Wang Z, Li M - Int J Nanomedicine (2012)

Bottom Line: The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%.The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds.The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China. sujiacan2012@yahoo.cn

ABSTRACT
A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

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Related in: MedlinePlus

(A) Scanning electron microscopic and (B) transmission electron microscopic images of the morphology of mesoporous bioactive glass.Note: Arrow represents mesoporous channels.
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f1-ijn-7-2547: (A) Scanning electron microscopic and (B) transmission electron microscopic images of the morphology of mesoporous bioactive glass.Note: Arrow represents mesoporous channels.

Mentions: SEM and TEM images of the m-BG are shown in Figure 1. Approximate sphere-like m-BG particles with a size of 0.1–1 μm are shown as an SEM image in Figure 1A. In the TEM image, it was found that homogeneously distributed mesopore channels appeared in the BG particle (shown as white line; Figure 1B).


Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair.

Su J, Cao L, Yu B, Song S, Liu X, Wang Z, Li M - Int J Nanomedicine (2012)

(A) Scanning electron microscopic and (B) transmission electron microscopic images of the morphology of mesoporous bioactive glass.Note: Arrow represents mesoporous channels.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3367494&req=5

f1-ijn-7-2547: (A) Scanning electron microscopic and (B) transmission electron microscopic images of the morphology of mesoporous bioactive glass.Note: Arrow represents mesoporous channels.
Mentions: SEM and TEM images of the m-BG are shown in Figure 1. Approximate sphere-like m-BG particles with a size of 0.1–1 μm are shown as an SEM image in Figure 1A. In the TEM image, it was found that homogeneously distributed mesopore channels appeared in the BG particle (shown as white line; Figure 1B).

Bottom Line: The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%.The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds.The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China. sujiacan2012@yahoo.cn

ABSTRACT
A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

Show MeSH
Related in: MedlinePlus