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Efficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy.

Inoue K, Fujimoto T, Higa R, Moriyama R, Kohmoto H, Nagumo H, Wakakura M, Tomita G - Clin Ophthalmol (2012)

Bottom Line: Mean IOP was 17.3 ± 2.7 mmHg before the switch, 15.5 ± 2.6 mmHg one month after the switch, 14.9 ± 2.4 mmHg 3 months after the switch, and 15.1 ± 2.2 mmHg 6 months after the switch, indicating that IOP decreased significantly after the change.The IOP reduction rate was 9.9% ± 11.5% after one month, 13.1% ± 10.9% after 3 months, and 11.2% ± 11.8% after 6 months.When latanoprost 0.005% eyedrop monotherapy was replaced by latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops, IOP decreased significantly without increasing the frequency of administration, and safety was satisfactory.

View Article: PubMed Central - PubMed

Affiliation: Inouye Eye Hospital, Chiyoda-ku, Tokyo.

ABSTRACT

Background: The purpose of this prospective study was to investigate the intraocular pressure (IOP)-lowering effect and safety of latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops, now available in Japan.

Materials and methods: Thirty-one patients diagnosed with primary open-angle glaucoma who had an insufficient intraocular pressure (IOP) decrease with latanoprost 0.005% eyedrop monotherapy were enrolled. The latanoprost 0.005% eyedrops were discontinued, and administration of latanoprost 0.005%/timolol maleate 0.5% fixed combination eyedrops was initiated without any washout period. IOP was compared before and at months 1, 3, and 6 after the switch. The incidence of adverse reactions was investigated at every follow-up visit.

Results: Mean IOP was 17.3 ± 2.7 mmHg before the switch, 15.5 ± 2.6 mmHg one month after the switch, 14.9 ± 2.4 mmHg 3 months after the switch, and 15.1 ± 2.2 mmHg 6 months after the switch, indicating that IOP decreased significantly after the change. The IOP reduction rate was 9.9% ± 11.5% after one month, 13.1% ± 10.9% after 3 months, and 11.2% ± 11.8% after 6 months. Two patients (6.5%) discontinued therapy due to adverse reactions (one case each of itchiness and bradycardia).

Conclusion: When latanoprost 0.005% eyedrop monotherapy was replaced by latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops, IOP decreased significantly without increasing the frequency of administration, and safety was satisfactory.

No MeSH data available.


Related in: MedlinePlus

Reductions in intraocular pressure 6 months after the switch to the fixed combination of latanoprost and timolol maleate.
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Related In: Results  -  Collection


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f2-opth-6-771: Reductions in intraocular pressure 6 months after the switch to the fixed combination of latanoprost and timolol maleate.

Mentions: The mean IOP was 15.5 ± 2.6 mmHg one month after the switch, 14.9 ± 2.4 mmHg 3 months after the switch, and 15.1 ± 2.2 mmHg 6 months after the switch. There was a significant decrease in IOP compared with the mean baseline value of 17.3 ± 2.7 mmHg before the switch (P < 0.0001, Figure 1). At 6 months after the switch, IOP had decreased by more than 2 mmHg in 17 cases (60.7%) and was within 1 mmHg in 11 cases (39.3%, Figure 2). Mean IOP reduction was 1.8 ± 2.2 mmHg one month after the switch, 2.4 ± 2.2 mmHg 3 months after the switch, and 2.1 ± 2.3 mmHg 6 months after the switch, which was not significantly different (P = 0.6408). The mean IOP reduction rate was 9.9% ± 11.5% one month after the switch, 13.1% ± 10.9% 3 months after the switch, and 11.2% ± 11.8% 6 months after the switch, which was not significantly different (P = 0.5682).


Efficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy.

Inoue K, Fujimoto T, Higa R, Moriyama R, Kohmoto H, Nagumo H, Wakakura M, Tomita G - Clin Ophthalmol (2012)

Reductions in intraocular pressure 6 months after the switch to the fixed combination of latanoprost and timolol maleate.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3367435&req=5

f2-opth-6-771: Reductions in intraocular pressure 6 months after the switch to the fixed combination of latanoprost and timolol maleate.
Mentions: The mean IOP was 15.5 ± 2.6 mmHg one month after the switch, 14.9 ± 2.4 mmHg 3 months after the switch, and 15.1 ± 2.2 mmHg 6 months after the switch. There was a significant decrease in IOP compared with the mean baseline value of 17.3 ± 2.7 mmHg before the switch (P < 0.0001, Figure 1). At 6 months after the switch, IOP had decreased by more than 2 mmHg in 17 cases (60.7%) and was within 1 mmHg in 11 cases (39.3%, Figure 2). Mean IOP reduction was 1.8 ± 2.2 mmHg one month after the switch, 2.4 ± 2.2 mmHg 3 months after the switch, and 2.1 ± 2.3 mmHg 6 months after the switch, which was not significantly different (P = 0.6408). The mean IOP reduction rate was 9.9% ± 11.5% one month after the switch, 13.1% ± 10.9% 3 months after the switch, and 11.2% ± 11.8% 6 months after the switch, which was not significantly different (P = 0.5682).

Bottom Line: Mean IOP was 17.3 ± 2.7 mmHg before the switch, 15.5 ± 2.6 mmHg one month after the switch, 14.9 ± 2.4 mmHg 3 months after the switch, and 15.1 ± 2.2 mmHg 6 months after the switch, indicating that IOP decreased significantly after the change.The IOP reduction rate was 9.9% ± 11.5% after one month, 13.1% ± 10.9% after 3 months, and 11.2% ± 11.8% after 6 months.When latanoprost 0.005% eyedrop monotherapy was replaced by latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops, IOP decreased significantly without increasing the frequency of administration, and safety was satisfactory.

View Article: PubMed Central - PubMed

Affiliation: Inouye Eye Hospital, Chiyoda-ku, Tokyo.

ABSTRACT

Background: The purpose of this prospective study was to investigate the intraocular pressure (IOP)-lowering effect and safety of latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops, now available in Japan.

Materials and methods: Thirty-one patients diagnosed with primary open-angle glaucoma who had an insufficient intraocular pressure (IOP) decrease with latanoprost 0.005% eyedrop monotherapy were enrolled. The latanoprost 0.005% eyedrops were discontinued, and administration of latanoprost 0.005%/timolol maleate 0.5% fixed combination eyedrops was initiated without any washout period. IOP was compared before and at months 1, 3, and 6 after the switch. The incidence of adverse reactions was investigated at every follow-up visit.

Results: Mean IOP was 17.3 ± 2.7 mmHg before the switch, 15.5 ± 2.6 mmHg one month after the switch, 14.9 ± 2.4 mmHg 3 months after the switch, and 15.1 ± 2.2 mmHg 6 months after the switch, indicating that IOP decreased significantly after the change. The IOP reduction rate was 9.9% ± 11.5% after one month, 13.1% ± 10.9% after 3 months, and 11.2% ± 11.8% after 6 months. Two patients (6.5%) discontinued therapy due to adverse reactions (one case each of itchiness and bradycardia).

Conclusion: When latanoprost 0.005% eyedrop monotherapy was replaced by latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops, IOP decreased significantly without increasing the frequency of administration, and safety was satisfactory.

No MeSH data available.


Related in: MedlinePlus