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African trypanosomiasis gambiense, Italy.

Bisoffi Z, Beltrame A, Monteiro G, Arzese A, Marocco S, Rorato G, Anselmi M, Viale P - Emerging Infect. Dis. (2005)

Bottom Line: We report 2 cases diagnosed in the summer of 2004.Theses cases suggest an increased risk for expatriates working in trypanosomiasis-endemic countries.Travel medicine clinics should be increasingly aware of this potentially fatal disease.

View Article: PubMed Central - PubMed

Affiliation: Centre for Tropical Diseases, Sacro Cuore Hospital of Negrar, Verona, Italy. zeno.bisoffi@sacrocuore.it

ABSTRACT
African trypanosomiasis caused by Trypanosoma brucei gambiense has not been reported in Italy. We report 2 cases diagnosed in the summer of 2004. Theses cases suggest an increased risk for expatriates working in trypanosomiasis-endemic countries. Travel medicine clinics should be increasingly aware of this potentially fatal disease.

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Trypomastigotes in a Giemsa-stained thin blood film of patient 2 (original magnification ×1,000).
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Figure 2: Trypomastigotes in a Giemsa-stained thin blood film of patient 2 (original magnification ×1,000).

Mentions: Three days later she returned with a fever. A quantitative buffy coat test result was negative for malaria, but this test showed viable trypomastigotes. They were also found in peripheral blood smears (Figure 2). Serologic results for T. brucei (IHA test) were positive (titer 1:128). Other relevant laboratory findings are shown in the Table. Results of CSF examination were normal. Since we could not treat this patient with eflornithine (WHO provides this drug only for stage 2 HAT), intramuscular pentamidine was administered at the dose of 4 mg/kg for 10 days. Tests to detect trypanosomes in blood were conducted daily for 8 days after treatment was initiated, but no trypomastigotes were found. Her clinical course was uneventful, except for a sterile abscess at the injection site. All laboratory findings improved markedly. She was afebrile and was discharged on day 25 in good condition, although she still had insomnia and headaches.


African trypanosomiasis gambiense, Italy.

Bisoffi Z, Beltrame A, Monteiro G, Arzese A, Marocco S, Rorato G, Anselmi M, Viale P - Emerging Infect. Dis. (2005)

Trypomastigotes in a Giemsa-stained thin blood film of patient 2 (original magnification ×1,000).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3367368&req=5

Figure 2: Trypomastigotes in a Giemsa-stained thin blood film of patient 2 (original magnification ×1,000).
Mentions: Three days later she returned with a fever. A quantitative buffy coat test result was negative for malaria, but this test showed viable trypomastigotes. They were also found in peripheral blood smears (Figure 2). Serologic results for T. brucei (IHA test) were positive (titer 1:128). Other relevant laboratory findings are shown in the Table. Results of CSF examination were normal. Since we could not treat this patient with eflornithine (WHO provides this drug only for stage 2 HAT), intramuscular pentamidine was administered at the dose of 4 mg/kg for 10 days. Tests to detect trypanosomes in blood were conducted daily for 8 days after treatment was initiated, but no trypomastigotes were found. Her clinical course was uneventful, except for a sterile abscess at the injection site. All laboratory findings improved markedly. She was afebrile and was discharged on day 25 in good condition, although she still had insomnia and headaches.

Bottom Line: We report 2 cases diagnosed in the summer of 2004.Theses cases suggest an increased risk for expatriates working in trypanosomiasis-endemic countries.Travel medicine clinics should be increasingly aware of this potentially fatal disease.

View Article: PubMed Central - PubMed

Affiliation: Centre for Tropical Diseases, Sacro Cuore Hospital of Negrar, Verona, Italy. zeno.bisoffi@sacrocuore.it

ABSTRACT
African trypanosomiasis caused by Trypanosoma brucei gambiense has not been reported in Italy. We report 2 cases diagnosed in the summer of 2004. Theses cases suggest an increased risk for expatriates working in trypanosomiasis-endemic countries. Travel medicine clinics should be increasingly aware of this potentially fatal disease.

Show MeSH
Related in: MedlinePlus