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Renal perfusion in scleroderma patients assessed by microbubble-based contrast-enhanced ultrasound.

Kleinert S, Roll P, Baumgaertner C, Himsel A, Mueller A, Fleck M, Feuchtenberger M, Jenett M, Tony HP - Open Rheumatol J (2012)

Bottom Line: Replenishment was recorded for 8 seconds.Time to maximal Enhancement (TmE), maximal enhancement (mE) and maximal enhancement relative to maximal enhancement of the interlobular artery (mE%A) were calculated for different ROIs.There was a linear correlation between the time to maximal enhancement in the parenchyma and the glomerular filtration rate.

View Article: PubMed Central - PubMed

Affiliation: University Hospital of Wuerzburg, Rheumatology/Clinical Immunology, Oberduerrbacherstr. 6, D-97080 Wuerzburg, Germany.

ABSTRACT

Objectives: Renal damage is common in scleroderma. It can occur acutely or chronically. Renal reserve might already be impaired before it can be detected by laboratory findings. Microbubble-based contrast-enhanced ultrasound has been demonstrated to improve blood perfusion imaging in organs. Therefore, we conducted a study to assess renal perfusion in scleroderma patients utilizing this novel technique.

Materials and methodology: Microbubble-based contrast agent was infused and destroyed by using high mechanical index by Siemens Sequoia (curved array, 4.5 MHz). Replenishment was recorded for 8 seconds. Regions of interests (ROI) were analyzed in renal parenchyma, interlobular artery and renal pyramid with quantitative contrast software (CUSQ 1.4, Siemens Acuson, Mountain View, California). Time to maximal Enhancement (TmE), maximal enhancement (mE) and maximal enhancement relative to maximal enhancement of the interlobular artery (mE%A) were calculated for different ROIs.

Results: There was a linear correlation between the time to maximal enhancement in the parenchyma and the glomerular filtration rate. However, the other parameters did not reveal significant differences between scleroderma patients and healthy controls.

Conclusion: Renal perfusion of scleroderma patients including the glomerular filtration rate can be assessed using microbubble-based contrast media.

No MeSH data available.


Related in: MedlinePlus

Example of characterization of renal perfusion in differentregions of interest. Destruction of microbubbles (**). Maximumenhancement (plateau) in renal parenchyma (red line, line of best fityellow) is close to maximum enhancement in the interlobular artery(green line, line of best fit pink). Blue line (line of best fit blue):renal pyramids.
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Figure 2: Example of characterization of renal perfusion in differentregions of interest. Destruction of microbubbles (**). Maximumenhancement (plateau) in renal parenchyma (red line, line of best fityellow) is close to maximum enhancement in the interlobular artery(green line, line of best fit pink). Blue line (line of best fit blue):renal pyramids.


Renal perfusion in scleroderma patients assessed by microbubble-based contrast-enhanced ultrasound.

Kleinert S, Roll P, Baumgaertner C, Himsel A, Mueller A, Fleck M, Feuchtenberger M, Jenett M, Tony HP - Open Rheumatol J (2012)

Example of characterization of renal perfusion in differentregions of interest. Destruction of microbubbles (**). Maximumenhancement (plateau) in renal parenchyma (red line, line of best fityellow) is close to maximum enhancement in the interlobular artery(green line, line of best fit pink). Blue line (line of best fit blue):renal pyramids.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3367302&req=5

Figure 2: Example of characterization of renal perfusion in differentregions of interest. Destruction of microbubbles (**). Maximumenhancement (plateau) in renal parenchyma (red line, line of best fityellow) is close to maximum enhancement in the interlobular artery(green line, line of best fit pink). Blue line (line of best fit blue):renal pyramids.
Bottom Line: Replenishment was recorded for 8 seconds.Time to maximal Enhancement (TmE), maximal enhancement (mE) and maximal enhancement relative to maximal enhancement of the interlobular artery (mE%A) were calculated for different ROIs.There was a linear correlation between the time to maximal enhancement in the parenchyma and the glomerular filtration rate.

View Article: PubMed Central - PubMed

Affiliation: University Hospital of Wuerzburg, Rheumatology/Clinical Immunology, Oberduerrbacherstr. 6, D-97080 Wuerzburg, Germany.

ABSTRACT

Objectives: Renal damage is common in scleroderma. It can occur acutely or chronically. Renal reserve might already be impaired before it can be detected by laboratory findings. Microbubble-based contrast-enhanced ultrasound has been demonstrated to improve blood perfusion imaging in organs. Therefore, we conducted a study to assess renal perfusion in scleroderma patients utilizing this novel technique.

Materials and methodology: Microbubble-based contrast agent was infused and destroyed by using high mechanical index by Siemens Sequoia (curved array, 4.5 MHz). Replenishment was recorded for 8 seconds. Regions of interests (ROI) were analyzed in renal parenchyma, interlobular artery and renal pyramid with quantitative contrast software (CUSQ 1.4, Siemens Acuson, Mountain View, California). Time to maximal Enhancement (TmE), maximal enhancement (mE) and maximal enhancement relative to maximal enhancement of the interlobular artery (mE%A) were calculated for different ROIs.

Results: There was a linear correlation between the time to maximal enhancement in the parenchyma and the glomerular filtration rate. However, the other parameters did not reveal significant differences between scleroderma patients and healthy controls.

Conclusion: Renal perfusion of scleroderma patients including the glomerular filtration rate can be assessed using microbubble-based contrast media.

No MeSH data available.


Related in: MedlinePlus