Limits...
Effect of age on clinical presentation and outcome of patients hospitalized with acute coronary syndrome: a 20-year registry in a middle eastern country.

Ahmed E, El-Menyar A, Singh R, Al Binali1 HA, Al Suwaidi J - Open Cardiovasc Med J (2012)

Bottom Line: Older age was associated with undertreatment with evidence-based therapies and had higher mortality rate.Over the study period, the relative reduction in mortality rates was higher in the younger compared with the older patients (61, 45.9 and 35.5%).Guidelines adherence and improvement in hospital care for elderly patients with ACS may potentially reduce morbidity and mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology and cardiovascular surgery, Heart Hospital, Hamad Medical Corporation (HMC), Doha, Qatar.

ABSTRACT

Introduction: Despite the fact that the elderly constitute an increasingly important group of patients with acute coronary syndrome (ACS), they are often excluded from clinical trials and are underrepresented in clinical registries.

Aims: To evaluate the impact of age in patients hospitalized with ACS.

Methods: Data collected for all patients presenting with ACS (n=16,744) who were admitted in Qatar during the period (1991-2010) and were analyzed according to age into 3 groups (≤50 years [41.4%], 51-70 years [48.7%] and >70 years [9.8%]).

Results: Older patients were more likely to be women and have hypertension, diabetes mellitus, and renal failure, while younger patients were more likely to be smokers. Non-ST-elevation myocardial infarction and heart failure were more prevalent in older patients. Older age was associated with undertreatment with evidence-based therapies and had higher mortality rate. Age was independent predictor for mortality. Over the study period, the relative reduction in mortality rates was higher in the younger compared with the older patients (61, 45.9 and 35.5%).

Conclusions: Despite being a higher-risk group, older patients were undertreated with evidence based therapy and had worse short-term outcome. Guidelines adherence and improvement in hospital care for elderly patients with ACS may potentially reduce morbidity and mortality.

No MeSH data available.


Related in: MedlinePlus

Trends in the number of hospitalization of patients according to age.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3367301&req=5

Figure 1: Trends in the number of hospitalization of patients according to age.

Mentions: Mortality rates across 20-year period in different age groups are shown in Fig. (2B). Older age ACS patients had significantly higher in-hospital mortality rate, cardiogenic shock, cardiac arrest, heart failure and stroke when compared with the younger age groups (p = 0.001). The mortality rates were higher in women when compared with men in all age groups [7.3 vs 3.1% in age ≤50 (P=0.001), 9% vs 5.4% (P=0.001) in between 51-70, and 17.2 vs 13% in age > 70 years (P=0.03).


Effect of age on clinical presentation and outcome of patients hospitalized with acute coronary syndrome: a 20-year registry in a middle eastern country.

Ahmed E, El-Menyar A, Singh R, Al Binali1 HA, Al Suwaidi J - Open Cardiovasc Med J (2012)

Trends in the number of hospitalization of patients according to age.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3367301&req=5

Figure 1: Trends in the number of hospitalization of patients according to age.
Mentions: Mortality rates across 20-year period in different age groups are shown in Fig. (2B). Older age ACS patients had significantly higher in-hospital mortality rate, cardiogenic shock, cardiac arrest, heart failure and stroke when compared with the younger age groups (p = 0.001). The mortality rates were higher in women when compared with men in all age groups [7.3 vs 3.1% in age ≤50 (P=0.001), 9% vs 5.4% (P=0.001) in between 51-70, and 17.2 vs 13% in age > 70 years (P=0.03).

Bottom Line: Older age was associated with undertreatment with evidence-based therapies and had higher mortality rate.Over the study period, the relative reduction in mortality rates was higher in the younger compared with the older patients (61, 45.9 and 35.5%).Guidelines adherence and improvement in hospital care for elderly patients with ACS may potentially reduce morbidity and mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology and cardiovascular surgery, Heart Hospital, Hamad Medical Corporation (HMC), Doha, Qatar.

ABSTRACT

Introduction: Despite the fact that the elderly constitute an increasingly important group of patients with acute coronary syndrome (ACS), they are often excluded from clinical trials and are underrepresented in clinical registries.

Aims: To evaluate the impact of age in patients hospitalized with ACS.

Methods: Data collected for all patients presenting with ACS (n=16,744) who were admitted in Qatar during the period (1991-2010) and were analyzed according to age into 3 groups (≤50 years [41.4%], 51-70 years [48.7%] and >70 years [9.8%]).

Results: Older patients were more likely to be women and have hypertension, diabetes mellitus, and renal failure, while younger patients were more likely to be smokers. Non-ST-elevation myocardial infarction and heart failure were more prevalent in older patients. Older age was associated with undertreatment with evidence-based therapies and had higher mortality rate. Age was independent predictor for mortality. Over the study period, the relative reduction in mortality rates was higher in the younger compared with the older patients (61, 45.9 and 35.5%).

Conclusions: Despite being a higher-risk group, older patients were undertreated with evidence based therapy and had worse short-term outcome. Guidelines adherence and improvement in hospital care for elderly patients with ACS may potentially reduce morbidity and mortality.

No MeSH data available.


Related in: MedlinePlus