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Chronic effects of a wild green oat extract supplementation on cognitive performance in older adults: a randomised, double-blind, placebo-controlled, crossover trial.

Wong RH, Howe PR, Bryan J, Coates AM, Buckley JD, Berry NM - Nutrients (2012)

Bottom Line: Chronic WGOE supplementation did not affect any measures of cognition.It appears that the cognitive benefit of acute WGOE supplementation does not persist with chronic treatment in older adults with normal cognition.It remains to be seen whether sustained effects of WGOE supplementation may be more evident in those with mild cognitive impairment.

View Article: PubMed Central - PubMed

Affiliation: Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia 5001, Australia. rachel.wong@mymail.unisa.edu.au

ABSTRACT

Background and aim: Preliminary evaluation of a wild green oat extract (WGOE) (Neuravena(®) ELFA(®)955, Frutarom, Switzerland) revealed an acute cognitive benefit of supplementation. This study investigated whether regular daily WGOE supplementation would result in sustained cognitive improvements.

Method: A 12-week randomised, double-blind, placebo-controlled cross-over trial of WGOE supplementation (1500 mg/day) versus placebo was undertaken in 37 healthy adults aged 67 ± 0.8 years (mean ± SEM). Cognitive assessments included the Stroop colour-word test, letter cancellation, the rule-shift task, a computerised multi-tasking test battery and the trail-making task. All assessments were conducted in Week 12 and repeated in Week 24 whilst subjects were fasted and at least 18 h after taking the last dose of supplement.

Result: Chronic WGOE supplementation did not affect any measures of cognition.

Conclusion: It appears that the cognitive benefit of acute WGOE supplementation does not persist with chronic treatment in older adults with normal cognition. It remains to be seen whether sustained effects of WGOE supplementation may be more evident in those with mild cognitive impairment.

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Related in: MedlinePlus

Outline of study design. During the screening visit (Week 0), participants underwent physiological and cognitive assessments including supine blood pressure (BP), DEMTECT and Stroop colour-word test to ensure their suitability for the study before they were randomized to a treatment arm. A complete battery of cognitive assessments was conducted in Week 12 before participants switched over to the alternate treatment and repeated the same assessment battery in Week 24.
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nutrients-04-00331-f001: Outline of study design. During the screening visit (Week 0), participants underwent physiological and cognitive assessments including supine blood pressure (BP), DEMTECT and Stroop colour-word test to ensure their suitability for the study before they were randomized to a treatment arm. A complete battery of cognitive assessments was conducted in Week 12 before participants switched over to the alternate treatment and repeated the same assessment battery in Week 24.

Mentions: Cognitive assessments were conducted in Week 12 and repeated in the same order in Week 24 of the trial (Figure 1). To reduce the possible influence of foods and medications on cognitive outcomes, participants arrived at the research centre at least 4 h fasted (no food, medication, fluids except water) and at least 18 h after taking their last treatment doses. One investigator was responsible for performing all cognitive assessments in the order listed below.


Chronic effects of a wild green oat extract supplementation on cognitive performance in older adults: a randomised, double-blind, placebo-controlled, crossover trial.

Wong RH, Howe PR, Bryan J, Coates AM, Buckley JD, Berry NM - Nutrients (2012)

Outline of study design. During the screening visit (Week 0), participants underwent physiological and cognitive assessments including supine blood pressure (BP), DEMTECT and Stroop colour-word test to ensure their suitability for the study before they were randomized to a treatment arm. A complete battery of cognitive assessments was conducted in Week 12 before participants switched over to the alternate treatment and repeated the same assessment battery in Week 24.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3367260&req=5

nutrients-04-00331-f001: Outline of study design. During the screening visit (Week 0), participants underwent physiological and cognitive assessments including supine blood pressure (BP), DEMTECT and Stroop colour-word test to ensure their suitability for the study before they were randomized to a treatment arm. A complete battery of cognitive assessments was conducted in Week 12 before participants switched over to the alternate treatment and repeated the same assessment battery in Week 24.
Mentions: Cognitive assessments were conducted in Week 12 and repeated in the same order in Week 24 of the trial (Figure 1). To reduce the possible influence of foods and medications on cognitive outcomes, participants arrived at the research centre at least 4 h fasted (no food, medication, fluids except water) and at least 18 h after taking their last treatment doses. One investigator was responsible for performing all cognitive assessments in the order listed below.

Bottom Line: Chronic WGOE supplementation did not affect any measures of cognition.It appears that the cognitive benefit of acute WGOE supplementation does not persist with chronic treatment in older adults with normal cognition.It remains to be seen whether sustained effects of WGOE supplementation may be more evident in those with mild cognitive impairment.

View Article: PubMed Central - PubMed

Affiliation: Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia 5001, Australia. rachel.wong@mymail.unisa.edu.au

ABSTRACT

Background and aim: Preliminary evaluation of a wild green oat extract (WGOE) (Neuravena(®) ELFA(®)955, Frutarom, Switzerland) revealed an acute cognitive benefit of supplementation. This study investigated whether regular daily WGOE supplementation would result in sustained cognitive improvements.

Method: A 12-week randomised, double-blind, placebo-controlled cross-over trial of WGOE supplementation (1500 mg/day) versus placebo was undertaken in 37 healthy adults aged 67 ± 0.8 years (mean ± SEM). Cognitive assessments included the Stroop colour-word test, letter cancellation, the rule-shift task, a computerised multi-tasking test battery and the trail-making task. All assessments were conducted in Week 12 and repeated in Week 24 whilst subjects were fasted and at least 18 h after taking the last dose of supplement.

Result: Chronic WGOE supplementation did not affect any measures of cognition.

Conclusion: It appears that the cognitive benefit of acute WGOE supplementation does not persist with chronic treatment in older adults with normal cognition. It remains to be seen whether sustained effects of WGOE supplementation may be more evident in those with mild cognitive impairment.

Show MeSH
Related in: MedlinePlus