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Prostatic hyperplasia is highly associated with nocturia and excessive sleepiness: a cross-sectional study.

Chartier-Kastler E, Leger D, Comet D, Haab F, Ohayon MM - BMJ Open (2012)

Bottom Line: Insomnia was mainly nocturnal awakenings with an average wake after sleep onset of 89±47 min.The number of episodes of nocturia per night correlated significantly with wake after sleep onset and ESS but not with total sleep time and sleep latency.Nocturia is significantly associated with sleep maintenance insomnia and sleepiness in men with BPE.

View Article: PubMed Central - PubMed

Affiliation: Faculté de médecine Pierre et Marie Curie, Paris VI, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

ABSTRACT

Objectives: The objective of this study is to assess the impact of nocturia on sleep in patients with lower urinary tract symptoms (LUTS)/benign prostatic enlargement (BPE) (nocturia≥2).

Design: Cross-sectional survey.

Setting: 798 urologists and general practitioners randomly selected from the overall population of urologists and general practitioners of every French region.

Participants: A total of 2179 LUTS/BPE men (aged 67.5±7.5 years old) were recruited.

Primary and secondary outcome measures: Validated patients' self-administered questionnaires were used to assess the severity of LUTS/BPE (the International Prostate Symptom Score), sleep characteristics (sleep log) and sleep disorders (the International Classification of Sleep Disorders (ICSD-2) and the DSM-IV). Sleepiness was assessed with the Epworth Sleepiness Scale (ESS). The volume of 24 h diuresis (1500 ml) was measured.

Results: Participants had on average 2.9±0.9 nocturia episodes (three or more episodes in 67%) and the International Prostate Symptom Score of 15.8±5.7; 60.9% complained of insomnia according to the ICSD-2, 7.9% of restless leg syndrome and 6.4% of obstructive sleep apnoea. 32.3% had excessive sleepiness (ESS >10) and 3.1% severe excessive sleepiness (ESS >16). Insomnia was mainly nocturnal awakenings with an average wake after sleep onset of 89±47 min. The number of episodes of nocturia per night correlated significantly with wake after sleep onset and ESS but not with total sleep time and sleep latency.

Conclusion: Nocturia is significantly associated with sleep maintenance insomnia and sleepiness in men with BPE.

No MeSH data available.


Related in: MedlinePlus

Impact of lower urinary tract symptoms/benign prostatic hyperplasia on sleep characteristics and sleepiness. SEI, sleep efficiency index; SL, sleep latency; TST, total sleep time; WASO, wake after sleep onset.
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fig2: Impact of lower urinary tract symptoms/benign prostatic hyperplasia on sleep characteristics and sleepiness. SEI, sleep efficiency index; SL, sleep latency; TST, total sleep time; WASO, wake after sleep onset.

Mentions: As expected, the number of reported nocturia episodes was associated with the number of awakenings (figure 2). However, a higher number of nocturia was also significantly associated with a higher WASO (from an average 70.5 min for one episode to 127.5 min for five or more episodes, p<0.001), TSP (p<0.001), a decreased sleep efficiency (from an average 79.0% for one episode to 69.2% for five or more episodes, p<0.001) and an increased total sleep period (from an average 8.6 h for one episode to 9.4 h for five or more episodes, p<0.001). Conversely, the sleep latency was not affected by the number of nocturia episodes and the TST also do not vary.


Prostatic hyperplasia is highly associated with nocturia and excessive sleepiness: a cross-sectional study.

Chartier-Kastler E, Leger D, Comet D, Haab F, Ohayon MM - BMJ Open (2012)

Impact of lower urinary tract symptoms/benign prostatic hyperplasia on sleep characteristics and sleepiness. SEI, sleep efficiency index; SL, sleep latency; TST, total sleep time; WASO, wake after sleep onset.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3367152&req=5

fig2: Impact of lower urinary tract symptoms/benign prostatic hyperplasia on sleep characteristics and sleepiness. SEI, sleep efficiency index; SL, sleep latency; TST, total sleep time; WASO, wake after sleep onset.
Mentions: As expected, the number of reported nocturia episodes was associated with the number of awakenings (figure 2). However, a higher number of nocturia was also significantly associated with a higher WASO (from an average 70.5 min for one episode to 127.5 min for five or more episodes, p<0.001), TSP (p<0.001), a decreased sleep efficiency (from an average 79.0% for one episode to 69.2% for five or more episodes, p<0.001) and an increased total sleep period (from an average 8.6 h for one episode to 9.4 h for five or more episodes, p<0.001). Conversely, the sleep latency was not affected by the number of nocturia episodes and the TST also do not vary.

Bottom Line: Insomnia was mainly nocturnal awakenings with an average wake after sleep onset of 89±47 min.The number of episodes of nocturia per night correlated significantly with wake after sleep onset and ESS but not with total sleep time and sleep latency.Nocturia is significantly associated with sleep maintenance insomnia and sleepiness in men with BPE.

View Article: PubMed Central - PubMed

Affiliation: Faculté de médecine Pierre et Marie Curie, Paris VI, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

ABSTRACT

Objectives: The objective of this study is to assess the impact of nocturia on sleep in patients with lower urinary tract symptoms (LUTS)/benign prostatic enlargement (BPE) (nocturia≥2).

Design: Cross-sectional survey.

Setting: 798 urologists and general practitioners randomly selected from the overall population of urologists and general practitioners of every French region.

Participants: A total of 2179 LUTS/BPE men (aged 67.5±7.5 years old) were recruited.

Primary and secondary outcome measures: Validated patients' self-administered questionnaires were used to assess the severity of LUTS/BPE (the International Prostate Symptom Score), sleep characteristics (sleep log) and sleep disorders (the International Classification of Sleep Disorders (ICSD-2) and the DSM-IV). Sleepiness was assessed with the Epworth Sleepiness Scale (ESS). The volume of 24 h diuresis (1500 ml) was measured.

Results: Participants had on average 2.9±0.9 nocturia episodes (three or more episodes in 67%) and the International Prostate Symptom Score of 15.8±5.7; 60.9% complained of insomnia according to the ICSD-2, 7.9% of restless leg syndrome and 6.4% of obstructive sleep apnoea. 32.3% had excessive sleepiness (ESS >10) and 3.1% severe excessive sleepiness (ESS >16). Insomnia was mainly nocturnal awakenings with an average wake after sleep onset of 89±47 min. The number of episodes of nocturia per night correlated significantly with wake after sleep onset and ESS but not with total sleep time and sleep latency.

Conclusion: Nocturia is significantly associated with sleep maintenance insomnia and sleepiness in men with BPE.

No MeSH data available.


Related in: MedlinePlus