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Antinociceptive, anti-inflammatory, and antipyretic activity of mangrove plants: a mini review.

Shilpi JA, Islam ME, Billah M, Islam KM, Sabrin F, Uddin SJ, Nahar L, Sarker SD - Adv Pharmacol Sci (2012)

Bottom Line: Their unique ecology and traditional medicinal uses of mangrove plants have attracted the attention of researchers over the years, and as a result, reports on biological activity of mangrove plants have increased significantly in recent years.This review has been set out to compile and appraise the results on antinociceptive, anti-inflammatory, and antipyretic activity of mangrove plants.A total of 29 reports on 17 plant species have been found to report such activities.

View Article: PubMed Central - PubMed

Affiliation: Pharmacy Discipline, Khulna University, Khulna 9208, Bangladesh.

ABSTRACT
Mangrove plants are specialised plants that grow in the tidal coasts of tropic and subtropic regions of the world. Their unique ecology and traditional medicinal uses of mangrove plants have attracted the attention of researchers over the years, and as a result, reports on biological activity of mangrove plants have increased significantly in recent years. This review has been set out to compile and appraise the results on antinociceptive, anti-inflammatory, and antipyretic activity of mangrove plants. While the Web of Knowledge, Google Scholar, and PubMed were the starting points to gather information, other pieces of relevant published literature were also adequately explored for this purpose. A total of 29 reports on 17 plant species have been found to report such activities. While 19 reports were on the biological activity of the crude extracts, 10 reports identified the active compound(s) of various chemical classes of natural products including terpenes, steroids, and flavonoids. This review finds that antinociceptive, anti-inflammatory, and antipyretic activity appears to be widespread in mangrove plants.

No MeSH data available.


Agallochaol O, an anti-inflammatory diterpene from the stems and twigs of Excoecaria agallocha.
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Related In: Results  -  Collection


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fig2: Agallochaol O, an anti-inflammatory diterpene from the stems and twigs of Excoecaria agallocha.

Mentions: The diterpenoids reported by Yodsaoue et al. [11] from the root extract of Caesalpinia mimosoides showed anti-inflammatory activity in micromolar range. The most potent activity was observed with mimosol D (Figure 1), which showed an IC50 for the inhibition of nitric oxide production at 3 μM and TNF-α production at 6.5 μM. Among the diterpenoids from the stems and twigs of the Chinese mangrove plant, Excoecaria agallocha, agallochaol O (Figure 2) at 100 μM showed 52.6% inhibition of interleukin-6 (IL-6) and other proinflammatory cytokines induced by lipopolysaccharide (LPS) [15]. Bio-assay guided phytochemical investigation of Ipomoea-pes-caprae resulted in the isolation of eugenol (Figure 3), a well-known analgesic, anti-inflammatory natural product [31, 33]. Some studies resulted in the isolation of steroids and triterpenes as the active compounds (Table 3) [32].


Antinociceptive, anti-inflammatory, and antipyretic activity of mangrove plants: a mini review.

Shilpi JA, Islam ME, Billah M, Islam KM, Sabrin F, Uddin SJ, Nahar L, Sarker SD - Adv Pharmacol Sci (2012)

Agallochaol O, an anti-inflammatory diterpene from the stems and twigs of Excoecaria agallocha.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3362808&req=5

fig2: Agallochaol O, an anti-inflammatory diterpene from the stems and twigs of Excoecaria agallocha.
Mentions: The diterpenoids reported by Yodsaoue et al. [11] from the root extract of Caesalpinia mimosoides showed anti-inflammatory activity in micromolar range. The most potent activity was observed with mimosol D (Figure 1), which showed an IC50 for the inhibition of nitric oxide production at 3 μM and TNF-α production at 6.5 μM. Among the diterpenoids from the stems and twigs of the Chinese mangrove plant, Excoecaria agallocha, agallochaol O (Figure 2) at 100 μM showed 52.6% inhibition of interleukin-6 (IL-6) and other proinflammatory cytokines induced by lipopolysaccharide (LPS) [15]. Bio-assay guided phytochemical investigation of Ipomoea-pes-caprae resulted in the isolation of eugenol (Figure 3), a well-known analgesic, anti-inflammatory natural product [31, 33]. Some studies resulted in the isolation of steroids and triterpenes as the active compounds (Table 3) [32].

Bottom Line: Their unique ecology and traditional medicinal uses of mangrove plants have attracted the attention of researchers over the years, and as a result, reports on biological activity of mangrove plants have increased significantly in recent years.This review has been set out to compile and appraise the results on antinociceptive, anti-inflammatory, and antipyretic activity of mangrove plants.A total of 29 reports on 17 plant species have been found to report such activities.

View Article: PubMed Central - PubMed

Affiliation: Pharmacy Discipline, Khulna University, Khulna 9208, Bangladesh.

ABSTRACT
Mangrove plants are specialised plants that grow in the tidal coasts of tropic and subtropic regions of the world. Their unique ecology and traditional medicinal uses of mangrove plants have attracted the attention of researchers over the years, and as a result, reports on biological activity of mangrove plants have increased significantly in recent years. This review has been set out to compile and appraise the results on antinociceptive, anti-inflammatory, and antipyretic activity of mangrove plants. While the Web of Knowledge, Google Scholar, and PubMed were the starting points to gather information, other pieces of relevant published literature were also adequately explored for this purpose. A total of 29 reports on 17 plant species have been found to report such activities. While 19 reports were on the biological activity of the crude extracts, 10 reports identified the active compound(s) of various chemical classes of natural products including terpenes, steroids, and flavonoids. This review finds that antinociceptive, anti-inflammatory, and antipyretic activity appears to be widespread in mangrove plants.

No MeSH data available.