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Seroepidemiology of human bocavirus infection in Jamaica.

Hustedt JW, Christie C, Hustedt MM, Esposito D, Vazquez M - PLoS ONE (2012)

Bottom Line: HBoV-specific antibodies were found to be present in 220/287 (76.7%) of samples collected from the pediatric population.Seroprevalence of HBoV was highest in those ≥2 years old.HBoV seroprevalence rates in the Caribbean are similar to those previously reported in other areas of the world.

View Article: PubMed Central - PubMed

Affiliation: Division of Infectious Diseases, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, United States of America. joshua.hustedt@yale.edu

ABSTRACT

Background: Human bocavirus (HBoV) is a newly identified human parvovirus. HBoV is associated with upper and lower respiratory tract infections and gastroenteritis in children. Little is known about the seroepidemiology of HBoV in populations in the Caribbean.

Methods: In a cross-sectional study conducted at the University Hospital of the West Indies in Kingston, Jamaica, 287 blood samples were collected from pediatric patients and tested for the presence of HBoV-specific antibody using a virus-like-particle based enzyme-linked immunosorbent assay (ELISA).

Results: HBoV-specific antibodies were found to be present in 220/287 (76.7%) of samples collected from the pediatric population. Seroprevalence of HBoV was highest in those ≥2 years old. The seroepidemiological profile suggests that most children are exposed to HBoV during the first two years of life in Jamaica.

Conclusion: HBoV infection is common in children in Jamaica. HBoV seroprevalence rates in the Caribbean are similar to those previously reported in other areas of the world.

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Related in: MedlinePlus

Seroepidemiology of HBoV shown by age group.The no. of serum samples screened and the percentage of seropositive individuals are shown for each age group; bars indicate standard errors.
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pone-0038206-g001: Seroepidemiology of HBoV shown by age group.The no. of serum samples screened and the percentage of seropositive individuals are shown for each age group; bars indicate standard errors.

Mentions: Overall, 220 (76.7%) of the 287 serum specimens were seropositive for HBoV antibody. Proportion of seropositivity varied by age group (Figure 1). Although 80% of newborns at birth were seropositive for HBoV, this proportion decreased to 50% by six months of age. After six months of age the proportion of seropositive subjects rapidly rebounded, so that by the age of 24 months >80% of children were seropositive. Age was a significant predictor of HBoV exposure in all children (P<0.001), with HBoV seropositive children being older (average age 30.3±17.3 months) than HBoV seronegative children (average age 17.8±12.7 months)


Seroepidemiology of human bocavirus infection in Jamaica.

Hustedt JW, Christie C, Hustedt MM, Esposito D, Vazquez M - PLoS ONE (2012)

Seroepidemiology of HBoV shown by age group.The no. of serum samples screened and the percentage of seropositive individuals are shown for each age group; bars indicate standard errors.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3362556&req=5

pone-0038206-g001: Seroepidemiology of HBoV shown by age group.The no. of serum samples screened and the percentage of seropositive individuals are shown for each age group; bars indicate standard errors.
Mentions: Overall, 220 (76.7%) of the 287 serum specimens were seropositive for HBoV antibody. Proportion of seropositivity varied by age group (Figure 1). Although 80% of newborns at birth were seropositive for HBoV, this proportion decreased to 50% by six months of age. After six months of age the proportion of seropositive subjects rapidly rebounded, so that by the age of 24 months >80% of children were seropositive. Age was a significant predictor of HBoV exposure in all children (P<0.001), with HBoV seropositive children being older (average age 30.3±17.3 months) than HBoV seronegative children (average age 17.8±12.7 months)

Bottom Line: HBoV-specific antibodies were found to be present in 220/287 (76.7%) of samples collected from the pediatric population.Seroprevalence of HBoV was highest in those ≥2 years old.HBoV seroprevalence rates in the Caribbean are similar to those previously reported in other areas of the world.

View Article: PubMed Central - PubMed

Affiliation: Division of Infectious Diseases, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, United States of America. joshua.hustedt@yale.edu

ABSTRACT

Background: Human bocavirus (HBoV) is a newly identified human parvovirus. HBoV is associated with upper and lower respiratory tract infections and gastroenteritis in children. Little is known about the seroepidemiology of HBoV in populations in the Caribbean.

Methods: In a cross-sectional study conducted at the University Hospital of the West Indies in Kingston, Jamaica, 287 blood samples were collected from pediatric patients and tested for the presence of HBoV-specific antibody using a virus-like-particle based enzyme-linked immunosorbent assay (ELISA).

Results: HBoV-specific antibodies were found to be present in 220/287 (76.7%) of samples collected from the pediatric population. Seroprevalence of HBoV was highest in those ≥2 years old. The seroepidemiological profile suggests that most children are exposed to HBoV during the first two years of life in Jamaica.

Conclusion: HBoV infection is common in children in Jamaica. HBoV seroprevalence rates in the Caribbean are similar to those previously reported in other areas of the world.

Show MeSH
Related in: MedlinePlus