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Impact of the -174 G > C IL-6 polymorphism on bioelectrical parameters in obese subjects after laparoscopic adjustable gastric banding.

Di Renzo L, Carbonelli MG, Bianchi A, Domino E, Migliore MR, Rillo G, Iacopino L, Di Daniele N, De Lorenzo A - J Obes (2012)

Bottom Line: LAGB surgery determined significant reductions in weight and BMI.After LAGB, in C(-) carriers, significant decreases in weight, BMI, and ECW and increases in BCM, BCMI, ICW, PA, and X(c)/H were highlighted.In C(+) carriers, significant reductions in weight, BMI, ICW, and PA and increases in ECW, Na/K, resistance (R), and R/height were obtained.

View Article: PubMed Central - PubMed

Affiliation: Division of Human Nutrition, Department of Neuroscience, University of Rome Tor Vergata, 00133 Rome, Italy.

ABSTRACT

Background: Recent data demonstrated that the -174 G > C IL-6 polymorphism may account for differences in the therapeutic response to laparoscopic adjustable gastric banding (LAGB) surgery.

Objective: We investigated the impact of -174 G > C IL-6 polymorphism on weight loss, body composition, and fluid distribution changes in obese subjects after LAGB.

Design and outcome measures: Twenty obese subjects were selected and studied at baseline and 3 months after LAGB. Genetic assessment of -174 G > C IL-6 polymorphism and anthropometric and bioelectrical impedance analysis were performed.

Results: At baseline, C(+) carriers had a lower extracellular water (ECW) and higher intra-CW, phase angle (PA), reactance X(c), and X(c)/height. LAGB surgery determined significant reductions in weight and BMI. After LAGB, in C(-) carriers, significant decreases in weight, BMI, and ECW and increases in BCM, BCMI, ICW, PA, and X(c)/H were highlighted. In C(+) carriers, significant reductions in weight, BMI, ICW, and PA and increases in ECW, Na/K, resistance (R), and R/height were obtained. Significant higher reductions in BMI and X(c)/H were observed in C(+) with respect to C(-) carriers.

Conclusions: Genotyping of genetic variants, for example, the -174 G > C polymorphism of IL-6, gives the opportunity to predict therapeutic response, in terms of body composition outcomes after LAGB.

No MeSH data available.


Related in: MedlinePlus

Relative changes of resistance over height (R/H) and reactance over height (Xc/H) 12 weeks after LAGB, according to genotypes. (Data are expressed as median, SD, and CI. SD, standard deviation; CI, confidence interval. *P ≤ 0.05 for C(−) carriers versus C(+) carriers with the Mann-Whitney test).
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fig2: Relative changes of resistance over height (R/H) and reactance over height (Xc/H) 12 weeks after LAGB, according to genotypes. (Data are expressed as median, SD, and CI. SD, standard deviation; CI, confidence interval. *P ≤ 0.05 for C(−) carriers versus C(+) carriers with the Mann-Whitney test).

Mentions: As reported in Figures 1 and 2, we highlighted a strong variability in relative changes of BMI, Xc/H, and R/H, after restrictive bariatric surgery, according to genotypes. Significant higher reduction in BMI (Δ% = −12.63 ± 4.11 versus Δ% = −8.00 ± 5.13; P ≤ 0.05), and Xc/H (Δ% = −2.79 ± 12.51 versus Δ% =  7.62 ± 11.63; P ≤ 0.05), was observed in C(+) with respect to C(−) carriers.


Impact of the -174 G > C IL-6 polymorphism on bioelectrical parameters in obese subjects after laparoscopic adjustable gastric banding.

Di Renzo L, Carbonelli MG, Bianchi A, Domino E, Migliore MR, Rillo G, Iacopino L, Di Daniele N, De Lorenzo A - J Obes (2012)

Relative changes of resistance over height (R/H) and reactance over height (Xc/H) 12 weeks after LAGB, according to genotypes. (Data are expressed as median, SD, and CI. SD, standard deviation; CI, confidence interval. *P ≤ 0.05 for C(−) carriers versus C(+) carriers with the Mann-Whitney test).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3362119&req=5

fig2: Relative changes of resistance over height (R/H) and reactance over height (Xc/H) 12 weeks after LAGB, according to genotypes. (Data are expressed as median, SD, and CI. SD, standard deviation; CI, confidence interval. *P ≤ 0.05 for C(−) carriers versus C(+) carriers with the Mann-Whitney test).
Mentions: As reported in Figures 1 and 2, we highlighted a strong variability in relative changes of BMI, Xc/H, and R/H, after restrictive bariatric surgery, according to genotypes. Significant higher reduction in BMI (Δ% = −12.63 ± 4.11 versus Δ% = −8.00 ± 5.13; P ≤ 0.05), and Xc/H (Δ% = −2.79 ± 12.51 versus Δ% =  7.62 ± 11.63; P ≤ 0.05), was observed in C(+) with respect to C(−) carriers.

Bottom Line: LAGB surgery determined significant reductions in weight and BMI.After LAGB, in C(-) carriers, significant decreases in weight, BMI, and ECW and increases in BCM, BCMI, ICW, PA, and X(c)/H were highlighted.In C(+) carriers, significant reductions in weight, BMI, ICW, and PA and increases in ECW, Na/K, resistance (R), and R/height were obtained.

View Article: PubMed Central - PubMed

Affiliation: Division of Human Nutrition, Department of Neuroscience, University of Rome Tor Vergata, 00133 Rome, Italy.

ABSTRACT

Background: Recent data demonstrated that the -174 G > C IL-6 polymorphism may account for differences in the therapeutic response to laparoscopic adjustable gastric banding (LAGB) surgery.

Objective: We investigated the impact of -174 G > C IL-6 polymorphism on weight loss, body composition, and fluid distribution changes in obese subjects after LAGB.

Design and outcome measures: Twenty obese subjects were selected and studied at baseline and 3 months after LAGB. Genetic assessment of -174 G > C IL-6 polymorphism and anthropometric and bioelectrical impedance analysis were performed.

Results: At baseline, C(+) carriers had a lower extracellular water (ECW) and higher intra-CW, phase angle (PA), reactance X(c), and X(c)/height. LAGB surgery determined significant reductions in weight and BMI. After LAGB, in C(-) carriers, significant decreases in weight, BMI, and ECW and increases in BCM, BCMI, ICW, PA, and X(c)/H were highlighted. In C(+) carriers, significant reductions in weight, BMI, ICW, and PA and increases in ECW, Na/K, resistance (R), and R/height were obtained. Significant higher reductions in BMI and X(c)/H were observed in C(+) with respect to C(-) carriers.

Conclusions: Genotyping of genetic variants, for example, the -174 G > C polymorphism of IL-6, gives the opportunity to predict therapeutic response, in terms of body composition outcomes after LAGB.

No MeSH data available.


Related in: MedlinePlus