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Curative effect of topical treatment of digital dermatitis with a gel containing activated copper and zinc chelate.

Holzhauer M, Bartels CJ, van Barneveld M, Vulders C, Lam T - Vet. Rec. (2011)

Bottom Line: Cure was defined as the transition of an M2 lesion into a healed (M0) or a non-painful chronic stage (M4) of BDD at D28.Subsequently, feet were photographed and scored on D28.The cure rate of M2 BDD lesions treated with IHF at D28 was 0.92 (CI 0.84 to 0.96) and was significantly better than for M2 BDD lesions treated with CTC, which was 0.58 (CI 0.47 to 0.68).

View Article: PubMed Central - PubMed

Affiliation: GD Deventer, Ruminant Health Department, Deventer, The Netherlands. m.holzhauer@gddeventer.com

ABSTRACT
The efficacy of two topical treatments for painful ulcerative stage (M2) of bovine digital dermatitis (BDD) lesions was compared in a clinical trial conducted on five dairy farms in 2009 to 2010. The first treatment was a water-based gel with active components copper and zinc (Intra Hoof-fit gel [IHF]) and the second treatment was a topical chlortetracycline spray (CTC spray). The experimental unit for this study was the hindleg with the presence of a BDD lesion. Cure was defined as the transition of an M2 lesion into a healed (M0) or a non-painful chronic stage (M4) of BDD at D28. On day 0, cows with M2 BDD lesions were photographed and were treated with either IHF or CTC. Subsequently, feet were photographed and scored on D28. The cure rate of M2 BDD lesions treated with IHF at D28 was 0.92 (CI 0.84 to 0.96) and was significantly better than for M2 BDD lesions treated with CTC, which was 0.58 (CI 0.47 to 0.68).

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Time frame for scorings and treatments of the different products according to protocol
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Figure 1: Time frame for scorings and treatments of the different products according to protocol

Mentions: In group A, 5 g of IHF was applied with a brush. The lesion was then covered with cotton wool and held in place by an elastic bandage (CoRip Flexible Cohesive Bandage GB 11). On D3 and D7, again approximately 5 g of IHF was applied by use of a brush, but without a bandage (see time frame, Fig 1). In group B, CTC was applied by spraying twice for three seconds from 15 to 20 cm distance with 30 seconds in-between treatments. This treatment was, accordingly the prescription of the producers,repeated at days 1 and 2. All scores, recordings and treatments were performed in a trimming chute by the same veterinarian (MvB). All hindlegs with M2 lesions were photographed at D0 and D28 for objective evaluation afterwards. No walk-through footbaths or other treatments were applied in the last three weeks before the start of and during the trial period. For reasons of practical feasibility, performance in regular herds and for financial reasons, no further histopathological investigation of the lesions was performed. Daily evaluations were performed by the dairy farmer for the presence of painful lesions. In case of necessary extra treatments, these were always executed with CTC (the registered product). These lesions were not followed up any further and were considered not to be cured. Cows that were treated for other reasons during the trial (eg, mastitis) were excluded.


Curative effect of topical treatment of digital dermatitis with a gel containing activated copper and zinc chelate.

Holzhauer M, Bartels CJ, van Barneveld M, Vulders C, Lam T - Vet. Rec. (2011)

Time frame for scorings and treatments of the different products according to protocol
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3361957&req=5

Figure 1: Time frame for scorings and treatments of the different products according to protocol
Mentions: In group A, 5 g of IHF was applied with a brush. The lesion was then covered with cotton wool and held in place by an elastic bandage (CoRip Flexible Cohesive Bandage GB 11). On D3 and D7, again approximately 5 g of IHF was applied by use of a brush, but without a bandage (see time frame, Fig 1). In group B, CTC was applied by spraying twice for three seconds from 15 to 20 cm distance with 30 seconds in-between treatments. This treatment was, accordingly the prescription of the producers,repeated at days 1 and 2. All scores, recordings and treatments were performed in a trimming chute by the same veterinarian (MvB). All hindlegs with M2 lesions were photographed at D0 and D28 for objective evaluation afterwards. No walk-through footbaths or other treatments were applied in the last three weeks before the start of and during the trial period. For reasons of practical feasibility, performance in regular herds and for financial reasons, no further histopathological investigation of the lesions was performed. Daily evaluations were performed by the dairy farmer for the presence of painful lesions. In case of necessary extra treatments, these were always executed with CTC (the registered product). These lesions were not followed up any further and were considered not to be cured. Cows that were treated for other reasons during the trial (eg, mastitis) were excluded.

Bottom Line: Cure was defined as the transition of an M2 lesion into a healed (M0) or a non-painful chronic stage (M4) of BDD at D28.Subsequently, feet were photographed and scored on D28.The cure rate of M2 BDD lesions treated with IHF at D28 was 0.92 (CI 0.84 to 0.96) and was significantly better than for M2 BDD lesions treated with CTC, which was 0.58 (CI 0.47 to 0.68).

View Article: PubMed Central - PubMed

Affiliation: GD Deventer, Ruminant Health Department, Deventer, The Netherlands. m.holzhauer@gddeventer.com

ABSTRACT
The efficacy of two topical treatments for painful ulcerative stage (M2) of bovine digital dermatitis (BDD) lesions was compared in a clinical trial conducted on five dairy farms in 2009 to 2010. The first treatment was a water-based gel with active components copper and zinc (Intra Hoof-fit gel [IHF]) and the second treatment was a topical chlortetracycline spray (CTC spray). The experimental unit for this study was the hindleg with the presence of a BDD lesion. Cure was defined as the transition of an M2 lesion into a healed (M0) or a non-painful chronic stage (M4) of BDD at D28. On day 0, cows with M2 BDD lesions were photographed and were treated with either IHF or CTC. Subsequently, feet were photographed and scored on D28. The cure rate of M2 BDD lesions treated with IHF at D28 was 0.92 (CI 0.84 to 0.96) and was significantly better than for M2 BDD lesions treated with CTC, which was 0.58 (CI 0.47 to 0.68).

Show MeSH
Related in: MedlinePlus