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Antiobesity effect of Stellaria media against drug induced obesity in Swiss albino mice.

Chidrawar VR, Patel KN, Sheth NR, Shiromwar SS, Trivedi P - Ayu (2011)

Bottom Line: MESM has also shown promising effects compared with alcoholic extract of S. media may be because of its multiple mechanisms.These findings suggest that antiobesity activity produced by MESM is because of its anorexic property mediated by saponin and flavonoid and partly of by its β-sitosterol content. β-Sitosterol in the plant extract was confirmed by thin-layer chromatography study. β-sitosterol is plant sterol having structural similarity with dietary fat which do the physical competition in the gastrointestinal tract and reduces fat absorption.By this study, it can be concluded that, MESM is beneficial in suppression of obesity induced by progesterone.

View Article: PubMed Central - PubMed

Affiliation: Associate Professor and Head, Department of Pharmacology, CMR College of Pharmacy, Medchal, Hyderabad, Andhra Pradesh.

ABSTRACT
The whole plant of Stellaria media (family: Caryophyllaceae) has been tested for its antiobesity activity by using progesterone-induced obesity model in female albino mice. The effect of S. media on food consumption pattern, change in body weight, thermogenesis, lipid metabolism, and histology of fat pad. were examined. Methanolic and alcoholic extracts of the S. media were used in the study. Methanolic extract of S. media (MESM) have prevented the increase in body weight, adipose tissue weight and size, and upturned obesity and associated complications. MESM has also shown promising effects compared with alcoholic extract of S. media may be because of its multiple mechanisms. These findings suggest that antiobesity activity produced by MESM is because of its anorexic property mediated by saponin and flavonoid and partly of by its β-sitosterol content. β-Sitosterol in the plant extract was confirmed by thin-layer chromatography study. β-sitosterol is plant sterol having structural similarity with dietary fat which do the physical competition in the gastrointestinal tract and reduces fat absorption. Before carrying in vivo activity detail pharmacognostic and phytochemical analysis of the extracts was carried out. The plant has shown the presence of saponin, flavonoids, steroids and triterpenoids, glycosides, and anthocynidine. By this study, it can be concluded that, MESM is beneficial in suppression of obesity induced by progesterone.

No MeSH data available.


Related in: MedlinePlus

Effect of Stellaria media on Progesterone modulated wet weight of organ / body weight ratio (mg / gm) in female mice (*Comparison of test and disease control with normal control, #Comparison test with Disease Control)
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Figure 5: Effect of Stellaria media on Progesterone modulated wet weight of organ / body weight ratio (mg / gm) in female mice (*Comparison of test and disease control with normal control, #Comparison test with Disease Control)

Mentions: Progesterone-treated group showed significant increase in WAT, adiposity index, and liver weight compared with normal control animals, which was significantly decreased by the co-administration with MESM 200 and 400 mg/kg compared with progesterone-treated and normal control group. Sibutramine was the most significant in this regard [Figure 5].


Antiobesity effect of Stellaria media against drug induced obesity in Swiss albino mice.

Chidrawar VR, Patel KN, Sheth NR, Shiromwar SS, Trivedi P - Ayu (2011)

Effect of Stellaria media on Progesterone modulated wet weight of organ / body weight ratio (mg / gm) in female mice (*Comparison of test and disease control with normal control, #Comparison test with Disease Control)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3361939&req=5

Figure 5: Effect of Stellaria media on Progesterone modulated wet weight of organ / body weight ratio (mg / gm) in female mice (*Comparison of test and disease control with normal control, #Comparison test with Disease Control)
Mentions: Progesterone-treated group showed significant increase in WAT, adiposity index, and liver weight compared with normal control animals, which was significantly decreased by the co-administration with MESM 200 and 400 mg/kg compared with progesterone-treated and normal control group. Sibutramine was the most significant in this regard [Figure 5].

Bottom Line: MESM has also shown promising effects compared with alcoholic extract of S. media may be because of its multiple mechanisms.These findings suggest that antiobesity activity produced by MESM is because of its anorexic property mediated by saponin and flavonoid and partly of by its β-sitosterol content. β-Sitosterol in the plant extract was confirmed by thin-layer chromatography study. β-sitosterol is plant sterol having structural similarity with dietary fat which do the physical competition in the gastrointestinal tract and reduces fat absorption.By this study, it can be concluded that, MESM is beneficial in suppression of obesity induced by progesterone.

View Article: PubMed Central - PubMed

Affiliation: Associate Professor and Head, Department of Pharmacology, CMR College of Pharmacy, Medchal, Hyderabad, Andhra Pradesh.

ABSTRACT
The whole plant of Stellaria media (family: Caryophyllaceae) has been tested for its antiobesity activity by using progesterone-induced obesity model in female albino mice. The effect of S. media on food consumption pattern, change in body weight, thermogenesis, lipid metabolism, and histology of fat pad. were examined. Methanolic and alcoholic extracts of the S. media were used in the study. Methanolic extract of S. media (MESM) have prevented the increase in body weight, adipose tissue weight and size, and upturned obesity and associated complications. MESM has also shown promising effects compared with alcoholic extract of S. media may be because of its multiple mechanisms. These findings suggest that antiobesity activity produced by MESM is because of its anorexic property mediated by saponin and flavonoid and partly of by its β-sitosterol content. β-Sitosterol in the plant extract was confirmed by thin-layer chromatography study. β-sitosterol is plant sterol having structural similarity with dietary fat which do the physical competition in the gastrointestinal tract and reduces fat absorption. Before carrying in vivo activity detail pharmacognostic and phytochemical analysis of the extracts was carried out. The plant has shown the presence of saponin, flavonoids, steroids and triterpenoids, glycosides, and anthocynidine. By this study, it can be concluded that, MESM is beneficial in suppression of obesity induced by progesterone.

No MeSH data available.


Related in: MedlinePlus