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Oral cyclosporine therapy for refractory severe vernal keratoconjunctivitis.

Gokhale NS, Samant R, Sharma V - Indian J Ophthalmol (2012 May-Jun)

Bottom Line: A child presented with severe allergy which was not controlled with topical steroids, cyclosporine and mast cell stabilizers.Oral steroids were required repeatedly to suppress inflammation.Oral cyclosporine therapy can be tried in severe vision-threatening allergy refractory to conventional therapy.

View Article: PubMed Central - PubMed

Affiliation: Gokhale Eye Hospital and Eyebank, Dadar, Mumbai, Maharashtra, India.

ABSTRACT
We report the success of oral cyclosporine therapy in a patient with severe vision-threatening vernal keratoconjunctivitis. A child presented with severe allergy which was not controlled with topical steroids, cyclosporine and mast cell stabilizers. Oral steroids were required repeatedly to suppress inflammation. Child showed a dramatic improvement and stabilization with oral cyclosporine therapy. Oral cyclosporine therapy can be tried in severe vision-threatening allergy refractory to conventional therapy.

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Related in: MedlinePlus

Right eye during remission shows burnt out inflammation. Annular limbal scarring, a central shield ulcer scar and diffuse subepithelial haze
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Figure 1: Right eye during remission shows burnt out inflammation. Annular limbal scarring, a central shield ulcer scar and diffuse subepithelial haze

Mentions: The child is on regular follow-up and is maintained on oral cyclosporine, topical loteprednol, olopatadine and lubricants. The child is significantly more comfortable now, there is a remission of inflammation and the ocular surface is stable, though it shows signs of a burned down inflammation [Figs. 1 and 2]. He however continues to have seasonal exacerbations [Table 1]. During the entire course of his treatment, the intraocular pressures were never high and no lens opacities were noted. Visual acuity at the last follow-up was 20/80 in right eye and 20/40 in the left eye.


Oral cyclosporine therapy for refractory severe vernal keratoconjunctivitis.

Gokhale NS, Samant R, Sharma V - Indian J Ophthalmol (2012 May-Jun)

Right eye during remission shows burnt out inflammation. Annular limbal scarring, a central shield ulcer scar and diffuse subepithelial haze
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3361821&req=5

Figure 1: Right eye during remission shows burnt out inflammation. Annular limbal scarring, a central shield ulcer scar and diffuse subepithelial haze
Mentions: The child is on regular follow-up and is maintained on oral cyclosporine, topical loteprednol, olopatadine and lubricants. The child is significantly more comfortable now, there is a remission of inflammation and the ocular surface is stable, though it shows signs of a burned down inflammation [Figs. 1 and 2]. He however continues to have seasonal exacerbations [Table 1]. During the entire course of his treatment, the intraocular pressures were never high and no lens opacities were noted. Visual acuity at the last follow-up was 20/80 in right eye and 20/40 in the left eye.

Bottom Line: A child presented with severe allergy which was not controlled with topical steroids, cyclosporine and mast cell stabilizers.Oral steroids were required repeatedly to suppress inflammation.Oral cyclosporine therapy can be tried in severe vision-threatening allergy refractory to conventional therapy.

View Article: PubMed Central - PubMed

Affiliation: Gokhale Eye Hospital and Eyebank, Dadar, Mumbai, Maharashtra, India.

ABSTRACT
We report the success of oral cyclosporine therapy in a patient with severe vision-threatening vernal keratoconjunctivitis. A child presented with severe allergy which was not controlled with topical steroids, cyclosporine and mast cell stabilizers. Oral steroids were required repeatedly to suppress inflammation. Child showed a dramatic improvement and stabilization with oral cyclosporine therapy. Oral cyclosporine therapy can be tried in severe vision-threatening allergy refractory to conventional therapy.

Show MeSH
Related in: MedlinePlus