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An increased incidence of Hodgkin's lymphoma in patients with adult-onset sarcoma.

Downing ME, Dite GS, Ballinger ML, International Sarcoma Kindred Study Consorti - Clin Sarcoma Res (2012)

Bottom Line: Multiple primary cancers were reported in 16% of probands, significantly higher than in the general population.The risk of HL in probands was increased 15.8-fold (95%CI 7.9-31.6) and increased risks were also seen for breast cancer (SIR 2.9, 95%CI 1.9-4.4) and thyroid cancer (SIR 8.4, 95%CI 4.2-16.8).Common risk factors for both may also exist, including both environmental and heritable factors.

View Article: PubMed Central - HTML - PubMed

Affiliation: Sarcoma Genomics and Genetics Laboratory, Research Division, The Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia. mandy.ballinger@petermac.org.

ABSTRACT

Background: Sarcomas are rare, often fatal malignancies of connective tissues that can occur in genetic predisposition syndromes or result from carcinogen exposure. Hodgkin's lymphoma (HL) is not known to contribute to any recognised familial cancer syndrome comprising sarcomas, but is known to be associated with a variety of second cancers, including sarcomas. This study describes the prevalence of HL in families affected by sarcoma.

Methods: The International Sarcoma Kindred Study (ISKS) is a prospective cohort of 561 families ascertained via a proband with adult-onset sarcoma. Cancer-specific standardised incidence ratios (SIR) for multiple primary malignancies in probands were estimated. Clinical characteristics of individuals reporting both sarcoma and HL were described. Standardised incidence ratios for the occurrence of cancer in ISKS families were also estimated.

Results: Multiple primary cancers were reported in 16% of probands, significantly higher than in the general population. The risk of HL in probands was increased 15.8-fold (95%CI 7.9-31.6) and increased risks were also seen for breast cancer (SIR 2.9, 95%CI 1.9-4.4) and thyroid cancer (SIR 8.4, 95%CI 4.2-16.8). In 8 probands with both HL and sarcoma, the diagnosis of HL preceded that of sarcoma in 7 cases, and occurred synchronously in one case. Only 3 cases of sarcoma occurred in or close to prior radiotherapy fields. The overall incidence of HL in the ISKS cohort was not significantly increased by comparison with age- and gender-specific population estimates (SIR 1.63, 95%CI 1.05-2.43), suggesting that the association between HL and sarcomas did not extend to other family members. The age of onset of non-sarcoma, non-HL cancers in families affected by both HL and sarcoma was younger than the general population (56.2 y vs 65.6 y, P < 0.0001).

Conclusions: The basis for the association between HL and sarcomas may include the carcinogenic effects of therapy combined with excellent survival rates for HL. Common risk factors for both may also exist, including both environmental and heritable factors.

No MeSH data available.


Related in: MedlinePlus

Cumulative risk for all cancers in ISKS probands (excluding sarcoma). Green = ISKS probands curve Light Blue = 95% confidence interval Grey = AIHW population curve.
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Figure 1: Cumulative risk for all cancers in ISKS probands (excluding sarcoma). Green = ISKS probands curve Light Blue = 95% confidence interval Grey = AIHW population curve.

Mentions: Overall, 2097 cancers were reported in 561 ISKS families, and included 561 sarcomas in probands and 1536 other cancers. Multiple primary malignancies were seen in 87 (16%) probands (see Table 1). In probands, there was an increased risk of HL (SIR 15.8, 95%CI 7.9-31.6), breast cancer (SIR 2.9, 95%CI 1.9-4.4) and thyroid cancer (SIR 8.4, 95%CI 4.2-16.8). There was an increased risk of cancer other than sarcoma in ISKS probands and the cumulative risk is shown in Figure 1, reinforcing the impression that sarcoma is associated with an increased incidence of other primary malignancies.


An increased incidence of Hodgkin's lymphoma in patients with adult-onset sarcoma.

Downing ME, Dite GS, Ballinger ML, International Sarcoma Kindred Study Consorti - Clin Sarcoma Res (2012)

Cumulative risk for all cancers in ISKS probands (excluding sarcoma). Green = ISKS probands curve Light Blue = 95% confidence interval Grey = AIHW population curve.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3351710&req=5

Figure 1: Cumulative risk for all cancers in ISKS probands (excluding sarcoma). Green = ISKS probands curve Light Blue = 95% confidence interval Grey = AIHW population curve.
Mentions: Overall, 2097 cancers were reported in 561 ISKS families, and included 561 sarcomas in probands and 1536 other cancers. Multiple primary malignancies were seen in 87 (16%) probands (see Table 1). In probands, there was an increased risk of HL (SIR 15.8, 95%CI 7.9-31.6), breast cancer (SIR 2.9, 95%CI 1.9-4.4) and thyroid cancer (SIR 8.4, 95%CI 4.2-16.8). There was an increased risk of cancer other than sarcoma in ISKS probands and the cumulative risk is shown in Figure 1, reinforcing the impression that sarcoma is associated with an increased incidence of other primary malignancies.

Bottom Line: Multiple primary cancers were reported in 16% of probands, significantly higher than in the general population.The risk of HL in probands was increased 15.8-fold (95%CI 7.9-31.6) and increased risks were also seen for breast cancer (SIR 2.9, 95%CI 1.9-4.4) and thyroid cancer (SIR 8.4, 95%CI 4.2-16.8).Common risk factors for both may also exist, including both environmental and heritable factors.

View Article: PubMed Central - HTML - PubMed

Affiliation: Sarcoma Genomics and Genetics Laboratory, Research Division, The Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia. mandy.ballinger@petermac.org.

ABSTRACT

Background: Sarcomas are rare, often fatal malignancies of connective tissues that can occur in genetic predisposition syndromes or result from carcinogen exposure. Hodgkin's lymphoma (HL) is not known to contribute to any recognised familial cancer syndrome comprising sarcomas, but is known to be associated with a variety of second cancers, including sarcomas. This study describes the prevalence of HL in families affected by sarcoma.

Methods: The International Sarcoma Kindred Study (ISKS) is a prospective cohort of 561 families ascertained via a proband with adult-onset sarcoma. Cancer-specific standardised incidence ratios (SIR) for multiple primary malignancies in probands were estimated. Clinical characteristics of individuals reporting both sarcoma and HL were described. Standardised incidence ratios for the occurrence of cancer in ISKS families were also estimated.

Results: Multiple primary cancers were reported in 16% of probands, significantly higher than in the general population. The risk of HL in probands was increased 15.8-fold (95%CI 7.9-31.6) and increased risks were also seen for breast cancer (SIR 2.9, 95%CI 1.9-4.4) and thyroid cancer (SIR 8.4, 95%CI 4.2-16.8). In 8 probands with both HL and sarcoma, the diagnosis of HL preceded that of sarcoma in 7 cases, and occurred synchronously in one case. Only 3 cases of sarcoma occurred in or close to prior radiotherapy fields. The overall incidence of HL in the ISKS cohort was not significantly increased by comparison with age- and gender-specific population estimates (SIR 1.63, 95%CI 1.05-2.43), suggesting that the association between HL and sarcomas did not extend to other family members. The age of onset of non-sarcoma, non-HL cancers in families affected by both HL and sarcoma was younger than the general population (56.2 y vs 65.6 y, P < 0.0001).

Conclusions: The basis for the association between HL and sarcomas may include the carcinogenic effects of therapy combined with excellent survival rates for HL. Common risk factors for both may also exist, including both environmental and heritable factors.

No MeSH data available.


Related in: MedlinePlus