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Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma.

Katz D, Boonsirikamchai P, Choi H, Lazar AJ, Wang WL, Xiao L, Park MS, Ravi V, Benjamin RS, Araujo DM - Clin Sarcoma Res (2012)

Bottom Line: The Kaplan-Meier method and log-rank test was used to estimate clinical outcomes.Median time to progression and overall survival time for the advanced-disease group were 23 and 31.1 months, respectively.Our study demonstrates that doxorubicin-ifosfamide combination therapy has a role in the treatment of MLS.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. daraujo@mdanderson.org.

ABSTRACT

Background: Myxoid liposarcoma (MLS) is a soft tissue sarcoma with adipocytic differentiation characterized by a unique chromosome rearrangement, t(12;16)(q13;p11). The exact efficacy of chemotherapy in MLS has not been clearly established.

Patients and methods: We retrospectively analyzed the records of 37 histologically confirmed MLS patients who were treated at the University of Texas MD Anderson Cancer Center from January 2000 to December 2009 with doxorubicin 75-90 mg/m2 over 72 hours combined with ifosfamide 10 gm/m2 in the first-line setting. Response was assessed using RECIST and Choi criteria. The Kaplan-Meier method and log-rank test was used to estimate clinical outcomes.

Results: The median follow-up period was 50.1 months. The overall response rates were 43.2% using RECIST and 86.5% using the Choi criteria. The 5-year disease-free survival rate was 90% for patients with resectable tumors. Median time to progression and overall survival time for the advanced-disease group were 23 and 31.1 months, respectively.

Conclusion: Our study demonstrates that doxorubicin-ifosfamide combination therapy has a role in the treatment of MLS. The Choi criteria may be more sensitive in evaluating response to chemotherapy in MLS.

No MeSH data available.


Related in: MedlinePlus

Disease-free survival in patients with resectable tumors (Neo) and in patients with advanced disease (Met).
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Figure 1: Disease-free survival in patients with resectable tumors (Neo) and in patients with advanced disease (Met).

Mentions: Table 2 summarizes responses determined using the RECIST and Choi criteria. Patients with resectable disease and patients with advanced disease did not differ significantly in response rates to AI (RECIST, p = 0.48; Choi criteria, p = 1.00). The PR rate for the entire cohort was 43% (n = 16) by RECIST and 87% (n = 32) by Choi criteria. The maximum tumor diameter decreased by an average of 28% (median 26%, range 5-57%.), and the mean time to maximum response was 4.4 months (median 4 months, range 2-10 months). No complete responses or disease progressions during preoperative treatment were recorded, and all patients with resectable disease underwent surgery with an R0 (curative) intent. Median follow-up for the entire group was 50.1 months (95% CI, 34-76.1 months). Six patients who received preoperative chemotherapy (two with positive margins) developed distant metastases diagnosed at a median of 23 months (range, 14-50 months) following surgery; two of these six patients died. The disease-free survival rate at 5 years for patients with resectable tumors was 90% (95% CI, 73.2-100%) (Figure 1). For the advanced-disease group, median time to progression (TTP) was 23 months (95% CI, 9.01-NA), and median overall survival was 31.1 months (95% CI, 20-NA) (Figure 2).


Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma.

Katz D, Boonsirikamchai P, Choi H, Lazar AJ, Wang WL, Xiao L, Park MS, Ravi V, Benjamin RS, Araujo DM - Clin Sarcoma Res (2012)

Disease-free survival in patients with resectable tumors (Neo) and in patients with advanced disease (Met).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3351704&req=5

Figure 1: Disease-free survival in patients with resectable tumors (Neo) and in patients with advanced disease (Met).
Mentions: Table 2 summarizes responses determined using the RECIST and Choi criteria. Patients with resectable disease and patients with advanced disease did not differ significantly in response rates to AI (RECIST, p = 0.48; Choi criteria, p = 1.00). The PR rate for the entire cohort was 43% (n = 16) by RECIST and 87% (n = 32) by Choi criteria. The maximum tumor diameter decreased by an average of 28% (median 26%, range 5-57%.), and the mean time to maximum response was 4.4 months (median 4 months, range 2-10 months). No complete responses or disease progressions during preoperative treatment were recorded, and all patients with resectable disease underwent surgery with an R0 (curative) intent. Median follow-up for the entire group was 50.1 months (95% CI, 34-76.1 months). Six patients who received preoperative chemotherapy (two with positive margins) developed distant metastases diagnosed at a median of 23 months (range, 14-50 months) following surgery; two of these six patients died. The disease-free survival rate at 5 years for patients with resectable tumors was 90% (95% CI, 73.2-100%) (Figure 1). For the advanced-disease group, median time to progression (TTP) was 23 months (95% CI, 9.01-NA), and median overall survival was 31.1 months (95% CI, 20-NA) (Figure 2).

Bottom Line: The Kaplan-Meier method and log-rank test was used to estimate clinical outcomes.Median time to progression and overall survival time for the advanced-disease group were 23 and 31.1 months, respectively.Our study demonstrates that doxorubicin-ifosfamide combination therapy has a role in the treatment of MLS.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. daraujo@mdanderson.org.

ABSTRACT

Background: Myxoid liposarcoma (MLS) is a soft tissue sarcoma with adipocytic differentiation characterized by a unique chromosome rearrangement, t(12;16)(q13;p11). The exact efficacy of chemotherapy in MLS has not been clearly established.

Patients and methods: We retrospectively analyzed the records of 37 histologically confirmed MLS patients who were treated at the University of Texas MD Anderson Cancer Center from January 2000 to December 2009 with doxorubicin 75-90 mg/m2 over 72 hours combined with ifosfamide 10 gm/m2 in the first-line setting. Response was assessed using RECIST and Choi criteria. The Kaplan-Meier method and log-rank test was used to estimate clinical outcomes.

Results: The median follow-up period was 50.1 months. The overall response rates were 43.2% using RECIST and 86.5% using the Choi criteria. The 5-year disease-free survival rate was 90% for patients with resectable tumors. Median time to progression and overall survival time for the advanced-disease group were 23 and 31.1 months, respectively.

Conclusion: Our study demonstrates that doxorubicin-ifosfamide combination therapy has a role in the treatment of MLS. The Choi criteria may be more sensitive in evaluating response to chemotherapy in MLS.

No MeSH data available.


Related in: MedlinePlus