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Effect of dietary arginine supplementation on reproductive performance of mice with porcine circovirus type 2 infection.

Ren W, Yin Y, Liu G, Yu X, Li Y, Yang G, Li T, Wu G - Amino Acids (2011)

Bottom Line: Further, litter number, litter birth weight and the daily weight gain of neonates increased in the arginine group compared to the control group.Arginine supplementation increased significantly the serum progesterone (P<0.01) and nitric oxide levels (P<0.05), but had little effect on the serum estrogen level.SOD activity and T-AOC in the arginine group were significantly higher (P<0.01) than the control group.

View Article: PubMed Central - PubMed

Affiliation: Research Center for Healthy Breeding of Livestock and Poultry, Hunan Engineering and Research Center of Animal and Poultry Science and Key Laboratory for Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Hunan, 410125, China.

ABSTRACT
The objective of this study was to investigate whether supplemental dietary arginine increases reproductive performance in mice infected with porcine circovirus type2 (PCV2). A total of 50KM female mice were allotted randomly to the arginine group (0.6% arginine+gestation diet) and control group (1.22% alanine+gestation diet). All the mice began to mate after 14 days of treatment with our prepared feed and challenged with PCV2 at the dose of 100 TCID50 (50% tissue culture infection dose, TCID50) after 7 days of pregnancy. Abortion rate, litter number, litter birth weight, the daily weight gain in the first 7 days and survival rate in the first 2 weeks of the neonates were calculated. The serum progesterone, estrogen, nitric oxide and superoxide dismutase (SOD) activity and total antioxidant capacity (T-AOC) on the 14th day of pregnancy were measured. Arginine supplementation decreased the abortion rate of pregnant mice and mortality of neonates caused by PCV2 infection. Further, litter number, litter birth weight and the daily weight gain of neonates increased in the arginine group compared to the control group. Arginine supplementation increased significantly the serum progesterone (P<0.01) and nitric oxide levels (P<0.05), but had little effect on the serum estrogen level. SOD activity and T-AOC in the arginine group were significantly higher (P<0.01) than the control group. In conclusion, arginine supplementation partially reversed the reproductive failure in mice caused by PCV2 infection.

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The survival rate of neonates in the arginine group and the control group; 0.6% Arg means 0.6% arginine + gestation diet; 1.22% Ala means 1.22% alanine + gestation diet. Sixty mice in the arginine group and 66 mice in the control group. All the mice were born from female mice infected with PCV2 after 7 days of pregnancy. PCV2 porcine circovirus type 2
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Fig2: The survival rate of neonates in the arginine group and the control group; 0.6% Arg means 0.6% arginine + gestation diet; 1.22% Ala means 1.22% alanine + gestation diet. Sixty mice in the arginine group and 66 mice in the control group. All the mice were born from female mice infected with PCV2 after 7 days of pregnancy. PCV2 porcine circovirus type 2

Mentions: Previous study found that the neonates could not growth normally and the survival rate was very low (data not shown) because of PCV2 infection. To judge the advantages of arginine supplementation of the neonates, we calculated the daily weight gain of neonates 7 days after birth. The survival rate of neonates was also calculated 14 days after birth. The result showed that arginine supplementation increased the daily weight gain of neonates (Table 2) and decreased the mortality caused by PCV2 infection (Fig. 2).Fig. 2


Effect of dietary arginine supplementation on reproductive performance of mice with porcine circovirus type 2 infection.

Ren W, Yin Y, Liu G, Yu X, Li Y, Yang G, Li T, Wu G - Amino Acids (2011)

The survival rate of neonates in the arginine group and the control group; 0.6% Arg means 0.6% arginine + gestation diet; 1.22% Ala means 1.22% alanine + gestation diet. Sixty mice in the arginine group and 66 mice in the control group. All the mice were born from female mice infected with PCV2 after 7 days of pregnancy. PCV2 porcine circovirus type 2
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3351591&req=5

Fig2: The survival rate of neonates in the arginine group and the control group; 0.6% Arg means 0.6% arginine + gestation diet; 1.22% Ala means 1.22% alanine + gestation diet. Sixty mice in the arginine group and 66 mice in the control group. All the mice were born from female mice infected with PCV2 after 7 days of pregnancy. PCV2 porcine circovirus type 2
Mentions: Previous study found that the neonates could not growth normally and the survival rate was very low (data not shown) because of PCV2 infection. To judge the advantages of arginine supplementation of the neonates, we calculated the daily weight gain of neonates 7 days after birth. The survival rate of neonates was also calculated 14 days after birth. The result showed that arginine supplementation increased the daily weight gain of neonates (Table 2) and decreased the mortality caused by PCV2 infection (Fig. 2).Fig. 2

Bottom Line: Further, litter number, litter birth weight and the daily weight gain of neonates increased in the arginine group compared to the control group.Arginine supplementation increased significantly the serum progesterone (P<0.01) and nitric oxide levels (P<0.05), but had little effect on the serum estrogen level.SOD activity and T-AOC in the arginine group were significantly higher (P<0.01) than the control group.

View Article: PubMed Central - PubMed

Affiliation: Research Center for Healthy Breeding of Livestock and Poultry, Hunan Engineering and Research Center of Animal and Poultry Science and Key Laboratory for Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Hunan, 410125, China.

ABSTRACT
The objective of this study was to investigate whether supplemental dietary arginine increases reproductive performance in mice infected with porcine circovirus type2 (PCV2). A total of 50KM female mice were allotted randomly to the arginine group (0.6% arginine+gestation diet) and control group (1.22% alanine+gestation diet). All the mice began to mate after 14 days of treatment with our prepared feed and challenged with PCV2 at the dose of 100 TCID50 (50% tissue culture infection dose, TCID50) after 7 days of pregnancy. Abortion rate, litter number, litter birth weight, the daily weight gain in the first 7 days and survival rate in the first 2 weeks of the neonates were calculated. The serum progesterone, estrogen, nitric oxide and superoxide dismutase (SOD) activity and total antioxidant capacity (T-AOC) on the 14th day of pregnancy were measured. Arginine supplementation decreased the abortion rate of pregnant mice and mortality of neonates caused by PCV2 infection. Further, litter number, litter birth weight and the daily weight gain of neonates increased in the arginine group compared to the control group. Arginine supplementation increased significantly the serum progesterone (P<0.01) and nitric oxide levels (P<0.05), but had little effect on the serum estrogen level. SOD activity and T-AOC in the arginine group were significantly higher (P<0.01) than the control group. In conclusion, arginine supplementation partially reversed the reproductive failure in mice caused by PCV2 infection.

Show MeSH
Related in: MedlinePlus