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Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.

Hyatt CJ, Assaf M, Muska CE, Rosen RI, Thomas AD, Johnson MR, Hylton JL, Andrews MM, Reynolds BA, Krystal JH, Potenza MN, Pearlson GD - PLoS ONE (2012)

Bottom Line: Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear.Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward.Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses).

View Article: PubMed Central - PubMed

Affiliation: Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut, United States of America. Chyatt@harthosp.org

ABSTRACT
Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear. We assessed blood-oxygenation-level dependent (BOLD) signal in ventral and dorsal striatum during functional magnetic resonance imaging (fMRI) in current (CCD; n = 30) and former (FCD; n = 28) cocaine dependent subjects as well as healthy control (HC; n = 31) subjects while playing an interactive competitive Domino game involving risk-taking and reward/punishment processing. Out-of-scanner impulsivity-related measures were also collected. Although both FCD and CCD subjects scored significantly higher on impulsivity-related measures than did HC subjects, only FCD subjects had differences in striatal activation, specifically showing hypoactivation during their response to gains versus losses in right dorsal caudate, a brain region linked to habituation, cocaine craving and addiction maintenance. Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward. These findings suggest that remitted cocaine dependence is associated with striatal dysfunction during social reward processing in a manner linked to compulsivity and reward sensitivity measures. Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses).

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A. Statistical parametric F-maps (coronal slices; y-dimension shown) of the one-way between-groups ANOVA multiple regression analysis of Factor 2 scores versus Gain-Loss contrast.Block white arrow points to the right dorsal caudate cluster that overlaps with the right dorsal caudate cluster shown in Figure 4, panel A. B. Statistical parametric t-maps (coronal slices; y-dimension shown) for the post hoc FCD group multiple regression analysis of Factor 2 scores versus Gain-Loss contrast. Threshold was set at q<0.05 FDR corrected; minimum cluster size k = 10 voxels (masked with the Reward mask). C. Plot of the Gain-Loss effect size versus Factor 2 score regression analysis, with each Gain-Loss contrast value being the mean value in a 5 mm radius sphere centered at peak voxel x,y,z  = 18,18,0 for each subject in the FCD group. The correlation coefficient of the fitted line was R = −0.641 (p = 0.0002 uncorrected).
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pone-0034917-g004: A. Statistical parametric F-maps (coronal slices; y-dimension shown) of the one-way between-groups ANOVA multiple regression analysis of Factor 2 scores versus Gain-Loss contrast.Block white arrow points to the right dorsal caudate cluster that overlaps with the right dorsal caudate cluster shown in Figure 4, panel A. B. Statistical parametric t-maps (coronal slices; y-dimension shown) for the post hoc FCD group multiple regression analysis of Factor 2 scores versus Gain-Loss contrast. Threshold was set at q<0.05 FDR corrected; minimum cluster size k = 10 voxels (masked with the Reward mask). C. Plot of the Gain-Loss effect size versus Factor 2 score regression analysis, with each Gain-Loss contrast value being the mean value in a 5 mm radius sphere centered at peak voxel x,y,z  = 18,18,0 for each subject in the FCD group. The correlation coefficient of the fitted line was R = −0.641 (p = 0.0002 uncorrected).

Mentions: A between-group ANOVA multiple regression analysis of Factor 2 impulsivity scores versus Gain-Loss contrast revealed several clusters within the Reward network at p<0.05 uncorrected, minimum cluster size, k = 10 voxels (see Table 4). One cluster was located in an ROI, the right dorsal caudate, as shown by the block arrow in Figure 4, panel A, at essentially the same location as the right dorsal caudate cluster in the between-group ANOVA main effect shown in Figure 3, panel A (peak cluster voxels at x,y,z  = 15,18,0 vs. 18,18,9).


Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.

Hyatt CJ, Assaf M, Muska CE, Rosen RI, Thomas AD, Johnson MR, Hylton JL, Andrews MM, Reynolds BA, Krystal JH, Potenza MN, Pearlson GD - PLoS ONE (2012)

A. Statistical parametric F-maps (coronal slices; y-dimension shown) of the one-way between-groups ANOVA multiple regression analysis of Factor 2 scores versus Gain-Loss contrast.Block white arrow points to the right dorsal caudate cluster that overlaps with the right dorsal caudate cluster shown in Figure 4, panel A. B. Statistical parametric t-maps (coronal slices; y-dimension shown) for the post hoc FCD group multiple regression analysis of Factor 2 scores versus Gain-Loss contrast. Threshold was set at q<0.05 FDR corrected; minimum cluster size k = 10 voxels (masked with the Reward mask). C. Plot of the Gain-Loss effect size versus Factor 2 score regression analysis, with each Gain-Loss contrast value being the mean value in a 5 mm radius sphere centered at peak voxel x,y,z  = 18,18,0 for each subject in the FCD group. The correlation coefficient of the fitted line was R = −0.641 (p = 0.0002 uncorrected).
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3351439&req=5

pone-0034917-g004: A. Statistical parametric F-maps (coronal slices; y-dimension shown) of the one-way between-groups ANOVA multiple regression analysis of Factor 2 scores versus Gain-Loss contrast.Block white arrow points to the right dorsal caudate cluster that overlaps with the right dorsal caudate cluster shown in Figure 4, panel A. B. Statistical parametric t-maps (coronal slices; y-dimension shown) for the post hoc FCD group multiple regression analysis of Factor 2 scores versus Gain-Loss contrast. Threshold was set at q<0.05 FDR corrected; minimum cluster size k = 10 voxels (masked with the Reward mask). C. Plot of the Gain-Loss effect size versus Factor 2 score regression analysis, with each Gain-Loss contrast value being the mean value in a 5 mm radius sphere centered at peak voxel x,y,z  = 18,18,0 for each subject in the FCD group. The correlation coefficient of the fitted line was R = −0.641 (p = 0.0002 uncorrected).
Mentions: A between-group ANOVA multiple regression analysis of Factor 2 impulsivity scores versus Gain-Loss contrast revealed several clusters within the Reward network at p<0.05 uncorrected, minimum cluster size, k = 10 voxels (see Table 4). One cluster was located in an ROI, the right dorsal caudate, as shown by the block arrow in Figure 4, panel A, at essentially the same location as the right dorsal caudate cluster in the between-group ANOVA main effect shown in Figure 3, panel A (peak cluster voxels at x,y,z  = 15,18,0 vs. 18,18,9).

Bottom Line: Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear.Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward.Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses).

View Article: PubMed Central - PubMed

Affiliation: Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut, United States of America. Chyatt@harthosp.org

ABSTRACT
Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear. We assessed blood-oxygenation-level dependent (BOLD) signal in ventral and dorsal striatum during functional magnetic resonance imaging (fMRI) in current (CCD; n = 30) and former (FCD; n = 28) cocaine dependent subjects as well as healthy control (HC; n = 31) subjects while playing an interactive competitive Domino game involving risk-taking and reward/punishment processing. Out-of-scanner impulsivity-related measures were also collected. Although both FCD and CCD subjects scored significantly higher on impulsivity-related measures than did HC subjects, only FCD subjects had differences in striatal activation, specifically showing hypoactivation during their response to gains versus losses in right dorsal caudate, a brain region linked to habituation, cocaine craving and addiction maintenance. Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward. These findings suggest that remitted cocaine dependence is associated with striatal dysfunction during social reward processing in a manner linked to compulsivity and reward sensitivity measures. Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses).

Show MeSH
Related in: MedlinePlus