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Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.

Hyatt CJ, Assaf M, Muska CE, Rosen RI, Thomas AD, Johnson MR, Hylton JL, Andrews MM, Reynolds BA, Krystal JH, Potenza MN, Pearlson GD - PLoS ONE (2012)

Bottom Line: Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear.Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward.Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses).

View Article: PubMed Central - PubMed

Affiliation: Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut, United States of America. Chyatt@harthosp.org

ABSTRACT
Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear. We assessed blood-oxygenation-level dependent (BOLD) signal in ventral and dorsal striatum during functional magnetic resonance imaging (fMRI) in current (CCD; n = 30) and former (FCD; n = 28) cocaine dependent subjects as well as healthy control (HC; n = 31) subjects while playing an interactive competitive Domino game involving risk-taking and reward/punishment processing. Out-of-scanner impulsivity-related measures were also collected. Although both FCD and CCD subjects scored significantly higher on impulsivity-related measures than did HC subjects, only FCD subjects had differences in striatal activation, specifically showing hypoactivation during their response to gains versus losses in right dorsal caudate, a brain region linked to habituation, cocaine craving and addiction maintenance. Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward. These findings suggest that remitted cocaine dependence is associated with striatal dysfunction during social reward processing in a manner linked to compulsivity and reward sensitivity measures. Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses).

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A. Statistical parametric F-maps (sagittal, coronal and axial) of the Gain-Loss contrast for one-way ANOVA between-group main effect (masked with the Reward mask).Crosshairs overlaid on brain slices are at located at x,y,z  = 18,18,9 (peak voxel). Glass brain at top right shows that the cluster in the right dorsal caudate is only surviving cluster. Threshold was set at p<0.05 uncorrected, minimum cluster size k = 10 voxels. B. Effect sizes for Gain (red), Loss (blue) and Gain-Loss (green) contrasts for HC, FCD and CCD groups at x,y,z  = 18,18,9. Black bar represents standard error of the mean.
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pone-0034917-g003: A. Statistical parametric F-maps (sagittal, coronal and axial) of the Gain-Loss contrast for one-way ANOVA between-group main effect (masked with the Reward mask).Crosshairs overlaid on brain slices are at located at x,y,z  = 18,18,9 (peak voxel). Glass brain at top right shows that the cluster in the right dorsal caudate is only surviving cluster. Threshold was set at p<0.05 uncorrected, minimum cluster size k = 10 voxels. B. Effect sizes for Gain (red), Loss (blue) and Gain-Loss (green) contrasts for HC, FCD and CCD groups at x,y,z  = 18,18,9. Black bar represents standard error of the mean.

Mentions: The masked one-way ANOVA analysis of the between-group differences for the Gain-Loss contrast yielded only one brain region with a group difference in activity, an ROI cluster (k = 18 voxels) in the right dorsal caudate (p<0.05 uncorrected, minimum cluster size k = 10; see Figure 3, panel A). Table 3, bottom, provides the location (MNI coordinates) and statistics for the right dorsal caudate region of significant between-group difference in activity.


Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game.

Hyatt CJ, Assaf M, Muska CE, Rosen RI, Thomas AD, Johnson MR, Hylton JL, Andrews MM, Reynolds BA, Krystal JH, Potenza MN, Pearlson GD - PLoS ONE (2012)

A. Statistical parametric F-maps (sagittal, coronal and axial) of the Gain-Loss contrast for one-way ANOVA between-group main effect (masked with the Reward mask).Crosshairs overlaid on brain slices are at located at x,y,z  = 18,18,9 (peak voxel). Glass brain at top right shows that the cluster in the right dorsal caudate is only surviving cluster. Threshold was set at p<0.05 uncorrected, minimum cluster size k = 10 voxels. B. Effect sizes for Gain (red), Loss (blue) and Gain-Loss (green) contrasts for HC, FCD and CCD groups at x,y,z  = 18,18,9. Black bar represents standard error of the mean.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3351439&req=5

pone-0034917-g003: A. Statistical parametric F-maps (sagittal, coronal and axial) of the Gain-Loss contrast for one-way ANOVA between-group main effect (masked with the Reward mask).Crosshairs overlaid on brain slices are at located at x,y,z  = 18,18,9 (peak voxel). Glass brain at top right shows that the cluster in the right dorsal caudate is only surviving cluster. Threshold was set at p<0.05 uncorrected, minimum cluster size k = 10 voxels. B. Effect sizes for Gain (red), Loss (blue) and Gain-Loss (green) contrasts for HC, FCD and CCD groups at x,y,z  = 18,18,9. Black bar represents standard error of the mean.
Mentions: The masked one-way ANOVA analysis of the between-group differences for the Gain-Loss contrast yielded only one brain region with a group difference in activity, an ROI cluster (k = 18 voxels) in the right dorsal caudate (p<0.05 uncorrected, minimum cluster size k = 10; see Figure 3, panel A). Table 3, bottom, provides the location (MNI coordinates) and statistics for the right dorsal caudate region of significant between-group difference in activity.

Bottom Line: Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear.Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward.Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses).

View Article: PubMed Central - PubMed

Affiliation: Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut, United States of America. Chyatt@harthosp.org

ABSTRACT
Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear. We assessed blood-oxygenation-level dependent (BOLD) signal in ventral and dorsal striatum during functional magnetic resonance imaging (fMRI) in current (CCD; n = 30) and former (FCD; n = 28) cocaine dependent subjects as well as healthy control (HC; n = 31) subjects while playing an interactive competitive Domino game involving risk-taking and reward/punishment processing. Out-of-scanner impulsivity-related measures were also collected. Although both FCD and CCD subjects scored significantly higher on impulsivity-related measures than did HC subjects, only FCD subjects had differences in striatal activation, specifically showing hypoactivation during their response to gains versus losses in right dorsal caudate, a brain region linked to habituation, cocaine craving and addiction maintenance. Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward. These findings suggest that remitted cocaine dependence is associated with striatal dysfunction during social reward processing in a manner linked to compulsivity and reward sensitivity measures. Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses).

Show MeSH
Related in: MedlinePlus