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The timing of goniosynechialysis in treatment of primary angle-closure glaucoma combined with cataract.

Yu J, Sun M, Wei Y, Cai X, He C, An X, Ye J - Mol. Vis. (2012)

Bottom Line: One anti-glaucoma medicine- was used for 1 eyes.Narrow anterior chamber angles in different extents also were observed in 4 eyes in Group B.However, there was no difference in the center anterior chamber's depth between these groups at the different points in time mentioned above.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Research Institute of Surgery & Daping Hospital, Third Military Medical University, Chongqing, P.R. China.

ABSTRACT

Purpose: To compare the clinical effects of phacoemulsification (PHACO) combined with goniosynechialysis (GSL) at different times in the treatment of primary angle-closure glaucoma (PACG) combined with cataract.

Methods: Before surgery, one or more different kinds of anti-glaucoma medicines were used for 24 patients (32 eyes) of PACG combined with cataract. A combination of PHACO with GSL procedures were performed on both groups of patients. The patients were randomly divided into two groups: 17 patients with 21 eyes were in Group A (GSL performed before lens was removed) and 7 patients with 11 eyes in Group B (GSL after extraction of crystal cortex). Changes in visual acuity, intraocular pressure (IOP) and the depth of the center anterior chamber were observed before surgery and again at 1 month, 3 months, 6 months, and 12 months after surgery.

Results: The mean visual acuity of Group A and Group B was 1.13±0.75 and 0.93±0.50, respectively. There was no statistical difference between these two groups in visual acuity before surgery. At 1 month, 3 months, 6 months, and 12 months after surgery, the visual acuities in Group A were 0.57±0.33, 0.42±0.24, 0.30±0.23, 0.35±0.28 and the visual acuities in Group B were 0.68±0.60, 0.38±0.15, 0.40±0.17,0.33±0.13, and 0.37±0.06. Visual acuity after surgery was greatly improved in both groups. However, there was no difference between these two groups at the different points in time mentioned above. The mean IOP before surgery was 35.67±12.31 mmHg and 31.64±15.06 mmHg for Group A and Group B, respectively. At 1 month, 3 months, 6 months, and 12 months after surgery, the IOP were normalized and were significantly lower than before surgery, in group A and B. However, there was no difference in IOP between these groups at the different points in time as mentioned above. One year after surgery, the percentages of success in Group A and Group B were 86.0% and 90.0%, respectively, qualified success rates in Group A and Group B were 9.5% and 10.0%, respectively. The failure rate in Group A was 4.8%, and no one failed in Group B. In Group A, the number of medications pre-operation was 2.05±0.74. A trabeculectomy was performed on 1 eye, and anti-glaucoma medicines were used for 2 eyes after surgery to normalize IOP. In Group B, the number of medications pre-operation was 2.18±0.87. One anti-glaucoma medicine- was used for 1 eyes. In different period after surgery, anterior chamber angles in Group A were all open. Narrow anterior chamber angles in different extents also were observed in 4 eyes in Group B. The mean depth of the center anterior chamber before surgery was 1.56±0.37 mmHg and 1.72±0.35 mmHg for Group A and Group B, respectively. At 1 month, 3 months, 6 months and 12 months after surgery, the center anterior chamber was deeper than that before surgery both in both groups . However, there was no difference in the center anterior chamber's depth between these groups at the different points in time mentioned above.

Conclusions: For PACG patients with cataracts, surgery methods are shown to improve visual acuity, decrease IOP, and expand the anterior chamber angle. Regarding the opening extent of the anterior chamber angle, surgery performed on Group A achieved better results than Group B.

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The group B show the chamber angle are closed pre-operation (in terms of UBM).
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f2: The group B show the chamber angle are closed pre-operation (in terms of UBM).

Mentions: This study adhered to the tenets of the Declaration of Helsinki. All participants signed the respective informed consent forms. The research was approved by the Ethics Committee of the Research Institute of Field Surgery, Da Ping Hospital, Third Military Medical University, Chongqing, P.R. China. Thirty-nine patients (52 eyes) with chronic angle-closure glaucoma with cataract were admitted to participate and were treated by us from June 2010 to June 2011: all patients were randomized into 2 groups (Group A or Group B) using a random number table created by SPSS statistical software (SPSS version 13.0; SPSS, Chicago, IL). Group A consisted of 20 patients and Group B consisted of 19 patients. Eight patients in Group A had PACG and cataracts in both eyes, and 5 patients in Group B had PACG and cataracts. Fifteen patients did not return to us during the study. Among the remaining 24 participants, 4 patients from both Group A and Group B suffered PACG and cataracts in both eyes Ten patients (14 eyes) were male and 14 cases (18 eyes) were female. The mean age of participants was 67.4±5.6 years. The lenses of all patients were nepheloid to different degrees. The degrees of cataract in all patients’ eyes were CII or CIII [5] according to the Lens Opacities Classification System, version II (LOCS II). The degrees of nuclear hardness in all eyes were equal to or more than grade III according to the Emery and Little nuclear hardness classification. According to the results of gonioscope and ultrasound biomicroscopy (UBM) examinations before surgery, anterior chamber angles had narrowed to different degrees (Figure 1 and Figure 2). The visual acuities of 10 eyes were between light perception and 0.1. The visual acuities of the other 24 eyes were between 0.1 and 0.5. The comparison of gender, age and visual acuity of patients between these two groups was free of statistical difference.


The timing of goniosynechialysis in treatment of primary angle-closure glaucoma combined with cataract.

Yu J, Sun M, Wei Y, Cai X, He C, An X, Ye J - Mol. Vis. (2012)

The group B show the chamber angle are closed pre-operation (in terms of UBM).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3351415&req=5

f2: The group B show the chamber angle are closed pre-operation (in terms of UBM).
Mentions: This study adhered to the tenets of the Declaration of Helsinki. All participants signed the respective informed consent forms. The research was approved by the Ethics Committee of the Research Institute of Field Surgery, Da Ping Hospital, Third Military Medical University, Chongqing, P.R. China. Thirty-nine patients (52 eyes) with chronic angle-closure glaucoma with cataract were admitted to participate and were treated by us from June 2010 to June 2011: all patients were randomized into 2 groups (Group A or Group B) using a random number table created by SPSS statistical software (SPSS version 13.0; SPSS, Chicago, IL). Group A consisted of 20 patients and Group B consisted of 19 patients. Eight patients in Group A had PACG and cataracts in both eyes, and 5 patients in Group B had PACG and cataracts. Fifteen patients did not return to us during the study. Among the remaining 24 participants, 4 patients from both Group A and Group B suffered PACG and cataracts in both eyes Ten patients (14 eyes) were male and 14 cases (18 eyes) were female. The mean age of participants was 67.4±5.6 years. The lenses of all patients were nepheloid to different degrees. The degrees of cataract in all patients’ eyes were CII or CIII [5] according to the Lens Opacities Classification System, version II (LOCS II). The degrees of nuclear hardness in all eyes were equal to or more than grade III according to the Emery and Little nuclear hardness classification. According to the results of gonioscope and ultrasound biomicroscopy (UBM) examinations before surgery, anterior chamber angles had narrowed to different degrees (Figure 1 and Figure 2). The visual acuities of 10 eyes were between light perception and 0.1. The visual acuities of the other 24 eyes were between 0.1 and 0.5. The comparison of gender, age and visual acuity of patients between these two groups was free of statistical difference.

Bottom Line: One anti-glaucoma medicine- was used for 1 eyes.Narrow anterior chamber angles in different extents also were observed in 4 eyes in Group B.However, there was no difference in the center anterior chamber's depth between these groups at the different points in time mentioned above.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Research Institute of Surgery & Daping Hospital, Third Military Medical University, Chongqing, P.R. China.

ABSTRACT

Purpose: To compare the clinical effects of phacoemulsification (PHACO) combined with goniosynechialysis (GSL) at different times in the treatment of primary angle-closure glaucoma (PACG) combined with cataract.

Methods: Before surgery, one or more different kinds of anti-glaucoma medicines were used for 24 patients (32 eyes) of PACG combined with cataract. A combination of PHACO with GSL procedures were performed on both groups of patients. The patients were randomly divided into two groups: 17 patients with 21 eyes were in Group A (GSL performed before lens was removed) and 7 patients with 11 eyes in Group B (GSL after extraction of crystal cortex). Changes in visual acuity, intraocular pressure (IOP) and the depth of the center anterior chamber were observed before surgery and again at 1 month, 3 months, 6 months, and 12 months after surgery.

Results: The mean visual acuity of Group A and Group B was 1.13±0.75 and 0.93±0.50, respectively. There was no statistical difference between these two groups in visual acuity before surgery. At 1 month, 3 months, 6 months, and 12 months after surgery, the visual acuities in Group A were 0.57±0.33, 0.42±0.24, 0.30±0.23, 0.35±0.28 and the visual acuities in Group B were 0.68±0.60, 0.38±0.15, 0.40±0.17,0.33±0.13, and 0.37±0.06. Visual acuity after surgery was greatly improved in both groups. However, there was no difference between these two groups at the different points in time mentioned above. The mean IOP before surgery was 35.67±12.31 mmHg and 31.64±15.06 mmHg for Group A and Group B, respectively. At 1 month, 3 months, 6 months, and 12 months after surgery, the IOP were normalized and were significantly lower than before surgery, in group A and B. However, there was no difference in IOP between these groups at the different points in time as mentioned above. One year after surgery, the percentages of success in Group A and Group B were 86.0% and 90.0%, respectively, qualified success rates in Group A and Group B were 9.5% and 10.0%, respectively. The failure rate in Group A was 4.8%, and no one failed in Group B. In Group A, the number of medications pre-operation was 2.05±0.74. A trabeculectomy was performed on 1 eye, and anti-glaucoma medicines were used for 2 eyes after surgery to normalize IOP. In Group B, the number of medications pre-operation was 2.18±0.87. One anti-glaucoma medicine- was used for 1 eyes. In different period after surgery, anterior chamber angles in Group A were all open. Narrow anterior chamber angles in different extents also were observed in 4 eyes in Group B. The mean depth of the center anterior chamber before surgery was 1.56±0.37 mmHg and 1.72±0.35 mmHg for Group A and Group B, respectively. At 1 month, 3 months, 6 months and 12 months after surgery, the center anterior chamber was deeper than that before surgery both in both groups . However, there was no difference in the center anterior chamber's depth between these groups at the different points in time mentioned above.

Conclusions: For PACG patients with cataracts, surgery methods are shown to improve visual acuity, decrease IOP, and expand the anterior chamber angle. Regarding the opening extent of the anterior chamber angle, surgery performed on Group A achieved better results than Group B.

Show MeSH
Related in: MedlinePlus