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Ultrasonic reflection coefficient and surface roughness index of OA articular cartilage: relation to pathological assessment.

Niu HJ, Wang Q, Wang YX, Li DY, Fan YB, Chen WF - BMC Musculoskelet Disord (2012)

Bottom Line: The results showed that URI increased with the OA grade.URI of the normal cartilage samples was significantly lower than the one of the OA cartilage samples.The reflection coefficient of the cartilage surface reduced significantly with the development of OA (p < 0.05), while the reflection coefficient of the cartilage-bone interface increased with the increase of grade.

View Article: PubMed Central - HTML - PubMed

Affiliation: Key Laboratory of the Ministry of Education for Biomechanics and Mechanobiology, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China. hjniu@buaa.edu.cn

ABSTRACT

Background: Early diagnosis of osteoarthritis (OA) is essential for preventing further cartilage destruction and decreasing severe complications. The aims of this study are to explore the relationship between OA pathological grades and quantitative acoustic parameters and to provide more objective criteria for ultrasonic microscopic evaluation of the OA cartilage.

Methods: Articular cartilage samples were prepared from rabbit knees and scanned using ultrasound biomicroscopy (UBM). Three quantitative parameters, including the roughness index of the cartilage surface (URI), the reflection coefficients from the cartilage surface (R) and from the cartilage-bone interface (Rbone) were extracted. The osteoarthritis grades of these cartilage samples were qualitatively assessed by histology according to the grading standards of International Osteoarthritis Institute (OARSI). The relationship between these quantitative parameters and the osteoarthritis grades was explored.

Results: The results showed that URI increased with the OA grade. URI of the normal cartilage samples was significantly lower than the one of the OA cartilage samples. There was no significant difference in URI between the grade 1 cartilage samples and the grade 2 cartilage samples. The reflection coefficient of the cartilage surface reduced significantly with the development of OA (p < 0.05), while the reflection coefficient of the cartilage-bone interface increased with the increase of grade.

Conclusion: High frequency ultrasound measurements can reflect the changes in the surface roughness index and the ultrasound reflection coefficients of the cartilage samples with different OA grades. This study may provide useful information for the quantitative ultrasonic diagnosis of early OA.

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The results of the statistical analysis of URI, R of the cartilage surface, and Rbone of the cartilage-bone surface of the OA cartilage samples with different grades in comparison with normal cartilage samples. * denotes significant difference at p < 0.05.
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Figure 4: The results of the statistical analysis of URI, R of the cartilage surface, and Rbone of the cartilage-bone surface of the OA cartilage samples with different grades in comparison with normal cartilage samples. * denotes significant difference at p < 0.05.

Mentions: Table 1 lists the parameters extracted from the ultrasonic echo signals, including URI of the cartilage surface and the reflection coefficients of the cartilage surface and the cartilage-bone interface. It was found that URI of the cartilage surface increased with the OA grade (Table 1 Figure 4a). URI of the normal cartilage samples (10.36 ± 5.82 μm) was significantly lower than that of the OA cartilage samples (grade 1 cartilage: 69.55 ± 27.43 μm; grade 2 cartilage: 76.86 ± 39.20 μm; grade 3 cartilage: 193.27 ± 75.06 μm) (p < 0.05). Additionally, URI of the OA cartilage with grade 3 is significantly higher than that of the OA cartilage with grade 1 and 2 (p < 0.05), while there was no significant difference in URI between the grade 1 cartilage samples and the grade 2 cartilage samples.


Ultrasonic reflection coefficient and surface roughness index of OA articular cartilage: relation to pathological assessment.

Niu HJ, Wang Q, Wang YX, Li DY, Fan YB, Chen WF - BMC Musculoskelet Disord (2012)

The results of the statistical analysis of URI, R of the cartilage surface, and Rbone of the cartilage-bone surface of the OA cartilage samples with different grades in comparison with normal cartilage samples. * denotes significant difference at p < 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3351369&req=5

Figure 4: The results of the statistical analysis of URI, R of the cartilage surface, and Rbone of the cartilage-bone surface of the OA cartilage samples with different grades in comparison with normal cartilage samples. * denotes significant difference at p < 0.05.
Mentions: Table 1 lists the parameters extracted from the ultrasonic echo signals, including URI of the cartilage surface and the reflection coefficients of the cartilage surface and the cartilage-bone interface. It was found that URI of the cartilage surface increased with the OA grade (Table 1 Figure 4a). URI of the normal cartilage samples (10.36 ± 5.82 μm) was significantly lower than that of the OA cartilage samples (grade 1 cartilage: 69.55 ± 27.43 μm; grade 2 cartilage: 76.86 ± 39.20 μm; grade 3 cartilage: 193.27 ± 75.06 μm) (p < 0.05). Additionally, URI of the OA cartilage with grade 3 is significantly higher than that of the OA cartilage with grade 1 and 2 (p < 0.05), while there was no significant difference in URI between the grade 1 cartilage samples and the grade 2 cartilage samples.

Bottom Line: The results showed that URI increased with the OA grade.URI of the normal cartilage samples was significantly lower than the one of the OA cartilage samples.The reflection coefficient of the cartilage surface reduced significantly with the development of OA (p < 0.05), while the reflection coefficient of the cartilage-bone interface increased with the increase of grade.

View Article: PubMed Central - HTML - PubMed

Affiliation: Key Laboratory of the Ministry of Education for Biomechanics and Mechanobiology, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China. hjniu@buaa.edu.cn

ABSTRACT

Background: Early diagnosis of osteoarthritis (OA) is essential for preventing further cartilage destruction and decreasing severe complications. The aims of this study are to explore the relationship between OA pathological grades and quantitative acoustic parameters and to provide more objective criteria for ultrasonic microscopic evaluation of the OA cartilage.

Methods: Articular cartilage samples were prepared from rabbit knees and scanned using ultrasound biomicroscopy (UBM). Three quantitative parameters, including the roughness index of the cartilage surface (URI), the reflection coefficients from the cartilage surface (R) and from the cartilage-bone interface (Rbone) were extracted. The osteoarthritis grades of these cartilage samples were qualitatively assessed by histology according to the grading standards of International Osteoarthritis Institute (OARSI). The relationship between these quantitative parameters and the osteoarthritis grades was explored.

Results: The results showed that URI increased with the OA grade. URI of the normal cartilage samples was significantly lower than the one of the OA cartilage samples. There was no significant difference in URI between the grade 1 cartilage samples and the grade 2 cartilage samples. The reflection coefficient of the cartilage surface reduced significantly with the development of OA (p < 0.05), while the reflection coefficient of the cartilage-bone interface increased with the increase of grade.

Conclusion: High frequency ultrasound measurements can reflect the changes in the surface roughness index and the ultrasound reflection coefficients of the cartilage samples with different OA grades. This study may provide useful information for the quantitative ultrasonic diagnosis of early OA.

Show MeSH
Related in: MedlinePlus