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A Pilot study of the Sharing Risk Information Tool (ShaRIT) for Families with Hereditary Breast and Ovarian Cancer Syndrome.

Kardashian A, Fehniger J, Creasman J, Cheung E, Beattie MS - Hered Cancer Clin Pract (2012)

Bottom Line: We developed the Sharing Risk Information Tool (ShaRIT), a personalized educational intervention, to support BRCA carriers as they discuss BRCA positive results and their implications with relatives.Characteristics associated with increased sharing and testing included: female gender, degree of relationship, and frequency of communication.In the future we hope to evaluate the effects of ShaRIT on family communication and family testing in larger populations of BRCA positive families.

View Article: PubMed Central - HTML - PubMed

Affiliation: University of California San Francisco Cancer Risk Program, 94115 San Francisco, CA, USA. Mary.Beattie@ucsfmedctr.org.

ABSTRACT

Background: Individuals who carry deleterious BRCA mutations face significantly elevated risks of breast, ovarian, and other cancers. These individuals are also responsible for informing relatives of their increased risk for carrying the family BRCA mutation. Few interventions have been developed to facilitate this family communication process.

Methods: We developed the Sharing Risk Information Tool (ShaRIT), a personalized educational intervention, to support BRCA carriers as they discuss BRCA positive results and their implications with relatives. We conducted a pilot study of 19 BRCA carriers identified through the University of California San Francisco Cancer Risk Program. Our study had two aims: 1) to assess the feasibility and acceptability of ShaRIT, and 2) describe characteristics associated with increased family communication and BRCA testing. Participants in our study were divided into two groups: those who had not received ShaRIT as part of their genetic counseling protocol (control group, n = 10) and those who received ShaRIT (n = 9).

Results: All 9 women who received ShaRIT reported that it was a useful resource. Characteristics associated with increased sharing and testing included: female gender, degree of relationship, and frequency of communication. Increased pedigree knowledge showed a trend toward higher rates of sharing.

Conclusions: Both participants and genetic counselors considered ShaRIT a well-received, comprehensive tool for disseminating individual risk information and clinical care guidelines to Hereditary Breast and Ovarian Cancer Syndrome families. Because of this, ShaRIT has been incorporated as standard of care at our institution. In the future we hope to evaluate the effects of ShaRIT on family communication and family testing in larger populations of BRCA positive families.

No MeSH data available.


Related in: MedlinePlus

Family pedigree of ShaRIT participant illustrating relative inclusion criteria. The pedigree of the participant (arrow), who tested positive, does not show a strong family history of HBOC on either the maternal or paternal side. The participant's mother tested negative for the known family mutation, so it was likely inherited from the participant's father. The participant's brother, two sisters (first-degree relatives), and paternal uncles represent first and second-degree relatives eligible for sharing results and family testing (stars). The participant's two daughters are too young to be included in sharing results or family testing analyses, as they are 7 and 5 years old.
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Figure 2: Family pedigree of ShaRIT participant illustrating relative inclusion criteria. The pedigree of the participant (arrow), who tested positive, does not show a strong family history of HBOC on either the maternal or paternal side. The participant's mother tested negative for the known family mutation, so it was likely inherited from the participant's father. The participant's brother, two sisters (first-degree relatives), and paternal uncles represent first and second-degree relatives eligible for sharing results and family testing (stars). The participant's two daughters are too young to be included in sharing results or family testing analyses, as they are 7 and 5 years old.

Mentions: Figures 1 and 2 show family pedigrees of two ShaRIT participants to illustrate how study inclusion criteria were applied to relatives for sharing results and for family testing.


A Pilot study of the Sharing Risk Information Tool (ShaRIT) for Families with Hereditary Breast and Ovarian Cancer Syndrome.

Kardashian A, Fehniger J, Creasman J, Cheung E, Beattie MS - Hered Cancer Clin Pract (2012)

Family pedigree of ShaRIT participant illustrating relative inclusion criteria. The pedigree of the participant (arrow), who tested positive, does not show a strong family history of HBOC on either the maternal or paternal side. The participant's mother tested negative for the known family mutation, so it was likely inherited from the participant's father. The participant's brother, two sisters (first-degree relatives), and paternal uncles represent first and second-degree relatives eligible for sharing results and family testing (stars). The participant's two daughters are too young to be included in sharing results or family testing analyses, as they are 7 and 5 years old.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3351367&req=5

Figure 2: Family pedigree of ShaRIT participant illustrating relative inclusion criteria. The pedigree of the participant (arrow), who tested positive, does not show a strong family history of HBOC on either the maternal or paternal side. The participant's mother tested negative for the known family mutation, so it was likely inherited from the participant's father. The participant's brother, two sisters (first-degree relatives), and paternal uncles represent first and second-degree relatives eligible for sharing results and family testing (stars). The participant's two daughters are too young to be included in sharing results or family testing analyses, as they are 7 and 5 years old.
Mentions: Figures 1 and 2 show family pedigrees of two ShaRIT participants to illustrate how study inclusion criteria were applied to relatives for sharing results and for family testing.

Bottom Line: We developed the Sharing Risk Information Tool (ShaRIT), a personalized educational intervention, to support BRCA carriers as they discuss BRCA positive results and their implications with relatives.Characteristics associated with increased sharing and testing included: female gender, degree of relationship, and frequency of communication.In the future we hope to evaluate the effects of ShaRIT on family communication and family testing in larger populations of BRCA positive families.

View Article: PubMed Central - HTML - PubMed

Affiliation: University of California San Francisco Cancer Risk Program, 94115 San Francisco, CA, USA. Mary.Beattie@ucsfmedctr.org.

ABSTRACT

Background: Individuals who carry deleterious BRCA mutations face significantly elevated risks of breast, ovarian, and other cancers. These individuals are also responsible for informing relatives of their increased risk for carrying the family BRCA mutation. Few interventions have been developed to facilitate this family communication process.

Methods: We developed the Sharing Risk Information Tool (ShaRIT), a personalized educational intervention, to support BRCA carriers as they discuss BRCA positive results and their implications with relatives. We conducted a pilot study of 19 BRCA carriers identified through the University of California San Francisco Cancer Risk Program. Our study had two aims: 1) to assess the feasibility and acceptability of ShaRIT, and 2) describe characteristics associated with increased family communication and BRCA testing. Participants in our study were divided into two groups: those who had not received ShaRIT as part of their genetic counseling protocol (control group, n = 10) and those who received ShaRIT (n = 9).

Results: All 9 women who received ShaRIT reported that it was a useful resource. Characteristics associated with increased sharing and testing included: female gender, degree of relationship, and frequency of communication. Increased pedigree knowledge showed a trend toward higher rates of sharing.

Conclusions: Both participants and genetic counselors considered ShaRIT a well-received, comprehensive tool for disseminating individual risk information and clinical care guidelines to Hereditary Breast and Ovarian Cancer Syndrome families. Because of this, ShaRIT has been incorporated as standard of care at our institution. In the future we hope to evaluate the effects of ShaRIT on family communication and family testing in larger populations of BRCA positive families.

No MeSH data available.


Related in: MedlinePlus