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Use of hepatitis C-positive donors in transplantation.

Abdala E, Azevedo LS, Campos SV, Caramori ML, Costa SF, Strabelli TM, Pierrotti LC, Varkulja GF, Almeida GM, Shikanai-Yasuda MA, Comissão de Infecção em Imunodeprimidos, Hospital das Clínicas da Faculdade de Medicina da U - Clinics (Sao Paulo) (2012)

View Article: PubMed Central - PubMed

Affiliation: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Liver transplant Service, Brazil.

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To establish a set of recommendations, we performed an analysis based on the data available in the literature... The following items were considered according to the type of transplantation: 1) the position on the list, 2) the urgency of transplantation, 3) the HCV infection status of the donor (serology, viral replication and histological activity), 4) the HCV infection status of the recipient (serology, viral replication and histological activity) and 5) the safety data available regarding the use of HCV-seropositive donors... The risk of the histological recurrence of hepatitis after transplantation is approximately 70%... The graft and recipient survival is lower compared with other etiologies... Descriptive and comparative studies and case-control analyses have shown that the use of seropositive donors for seropositive recipients does not interfere with graft or patient survival. 2... Kidney Transplantation Some descriptive studies have shown that the use of seropositive donors for seropositive recipients does not interfere with graft or patient survival... However, in a multicenter survey, 72% of the participating groups considered the use of HCV-seropositive donors for HCV-seropositive recipients... Because HSCT often involves situations in which there is an imminent risk of death and the need for an HLA-matched living donor, the decision should be based on the urgency of the Tx and level of viremia in the donor... Liver Transplantation Accept HCV-seropositive donor for HCV-seropositive recipient since donor liver biopsy has not provided evidence of liver disease in a recipient with positive HCV viremia. 2... Kidney Transplantation Accept HCV-seropositive donors for HCV-seropositive recipients with positive viremia (BII). 3... Lung Transplantation In centers that accept recipients with HCV-positive viremia, accept HCV-seropositive donors (CIII). 4... The authors wish to thank Profs... José Otávio Costa Auler Júnior, Tarcísio Eloi Pessoa de Barros Filho and Eloísa Bonfá for their support as Clinical Directors of the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo.

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Use of hepatitis C-positive donors in transplantation.

Abdala E, Azevedo LS, Campos SV, Caramori ML, Costa SF, Strabelli TM, Pierrotti LC, Varkulja GF, Almeida GM, Shikanai-Yasuda MA, Comissão de Infecção em Imunodeprimidos, Hospital das Clínicas da Faculdade de Medicina da U - Clinics (Sao Paulo) (2012)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3351258&req=5

View Article: PubMed Central - PubMed

Affiliation: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Liver transplant Service, Brazil.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

To establish a set of recommendations, we performed an analysis based on the data available in the literature... The following items were considered according to the type of transplantation: 1) the position on the list, 2) the urgency of transplantation, 3) the HCV infection status of the donor (serology, viral replication and histological activity), 4) the HCV infection status of the recipient (serology, viral replication and histological activity) and 5) the safety data available regarding the use of HCV-seropositive donors... The risk of the histological recurrence of hepatitis after transplantation is approximately 70%... The graft and recipient survival is lower compared with other etiologies... Descriptive and comparative studies and case-control analyses have shown that the use of seropositive donors for seropositive recipients does not interfere with graft or patient survival. 2... Kidney Transplantation Some descriptive studies have shown that the use of seropositive donors for seropositive recipients does not interfere with graft or patient survival... However, in a multicenter survey, 72% of the participating groups considered the use of HCV-seropositive donors for HCV-seropositive recipients... Because HSCT often involves situations in which there is an imminent risk of death and the need for an HLA-matched living donor, the decision should be based on the urgency of the Tx and level of viremia in the donor... Liver Transplantation Accept HCV-seropositive donor for HCV-seropositive recipient since donor liver biopsy has not provided evidence of liver disease in a recipient with positive HCV viremia. 2... Kidney Transplantation Accept HCV-seropositive donors for HCV-seropositive recipients with positive viremia (BII). 3... Lung Transplantation In centers that accept recipients with HCV-positive viremia, accept HCV-seropositive donors (CIII). 4... The authors wish to thank Profs... José Otávio Costa Auler Júnior, Tarcísio Eloi Pessoa de Barros Filho and Eloísa Bonfá for their support as Clinical Directors of the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo.

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