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Early detection of ovarian cancer with conventional and contrast-enhanced transvaginal sonography: recent advances and potential improvements.

Fleischer AC, Lyshchik A, Hirari M, Moore RD, Abramson RG, Fishman DA - J Oncol (2012)

Bottom Line: These include improved assessment of tumor morphology with transvaginal sonography (TVS), and detection and characterization of tumor neovascularity with transvaginal color Doppler sonography (TV-CDS) and contrast-enhanced transvaginal sonography (CE-TVS).This paper will discuss and illustrate these improvements and describe how they enhance detection of early-stage ovarian cancer.Our initial experience with parametric mapping of CE-TVS will also be mentioned.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, 37232 Nashville, TN, USA.

ABSTRACT
Recently, there have been several major technical advances in the sonographic diagnosis of ovarian cancer in its early stages. These include improved assessment of tumor morphology with transvaginal sonography (TVS), and detection and characterization of tumor neovascularity with transvaginal color Doppler sonography (TV-CDS) and contrast-enhanced transvaginal sonography (CE-TVS). This paper will discuss and illustrate these improvements and describe how they enhance detection of early-stage ovarian cancer. Our initial experience with parametric mapping of CE-TVS will also be mentioned.

No MeSH data available.


Related in: MedlinePlus

Receiver operator characteristic of various parameters showing cutoff points for vascular index (VI), flow index (FI), and vascular flow index (VFI) (from [2]).
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fig12: Receiver operator characteristic of various parameters showing cutoff points for vascular index (VI), flow index (FI), and vascular flow index (VFI) (from [2]).

Mentions: AUC greater than 787 seconds−1 was the most accurate diagnostic criterion for ovarian cancer, with 100.0% sensitivity and 96.2% specificity. Additionally, PE greater than 17.2 dB (90.0% sensitivity and 98.3% specificity) and a (1/2)Two of greater than 41.0 seconds (100.0% sensitivity and 92.3% specificity) proved to be useful. Initial analysis of contrast-enhanced kinetic was done using time intensity curves for mean, standard deviation, and P value (Figures 9 and 11) and subsequently by receive operator characteristic curves for vascular index (VI); flow index (FI); vascular flow index (VFI) (Figure 12). The receiver operator characteristics of each parameter is shown in Figure 13 with predetermined cutoff values as established with receive operation curves and compared to VI, FI, and VFI values. These results show that contrast-enhanced nonlinear pulse inversion sonography is a more appropriate method for characterizing blood flow dynamics in ovarian tumors than by TV-CDS and can provide an important tool to aid differential diagnoses between benign and malignant ovarian tumors.


Early detection of ovarian cancer with conventional and contrast-enhanced transvaginal sonography: recent advances and potential improvements.

Fleischer AC, Lyshchik A, Hirari M, Moore RD, Abramson RG, Fishman DA - J Oncol (2012)

Receiver operator characteristic of various parameters showing cutoff points for vascular index (VI), flow index (FI), and vascular flow index (VFI) (from [2]).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3351123&req=5

fig12: Receiver operator characteristic of various parameters showing cutoff points for vascular index (VI), flow index (FI), and vascular flow index (VFI) (from [2]).
Mentions: AUC greater than 787 seconds−1 was the most accurate diagnostic criterion for ovarian cancer, with 100.0% sensitivity and 96.2% specificity. Additionally, PE greater than 17.2 dB (90.0% sensitivity and 98.3% specificity) and a (1/2)Two of greater than 41.0 seconds (100.0% sensitivity and 92.3% specificity) proved to be useful. Initial analysis of contrast-enhanced kinetic was done using time intensity curves for mean, standard deviation, and P value (Figures 9 and 11) and subsequently by receive operator characteristic curves for vascular index (VI); flow index (FI); vascular flow index (VFI) (Figure 12). The receiver operator characteristics of each parameter is shown in Figure 13 with predetermined cutoff values as established with receive operation curves and compared to VI, FI, and VFI values. These results show that contrast-enhanced nonlinear pulse inversion sonography is a more appropriate method for characterizing blood flow dynamics in ovarian tumors than by TV-CDS and can provide an important tool to aid differential diagnoses between benign and malignant ovarian tumors.

Bottom Line: These include improved assessment of tumor morphology with transvaginal sonography (TVS), and detection and characterization of tumor neovascularity with transvaginal color Doppler sonography (TV-CDS) and contrast-enhanced transvaginal sonography (CE-TVS).This paper will discuss and illustrate these improvements and describe how they enhance detection of early-stage ovarian cancer.Our initial experience with parametric mapping of CE-TVS will also be mentioned.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, 37232 Nashville, TN, USA.

ABSTRACT
Recently, there have been several major technical advances in the sonographic diagnosis of ovarian cancer in its early stages. These include improved assessment of tumor morphology with transvaginal sonography (TVS), and detection and characterization of tumor neovascularity with transvaginal color Doppler sonography (TV-CDS) and contrast-enhanced transvaginal sonography (CE-TVS). This paper will discuss and illustrate these improvements and describe how they enhance detection of early-stage ovarian cancer. Our initial experience with parametric mapping of CE-TVS will also be mentioned.

No MeSH data available.


Related in: MedlinePlus