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Early detection of ovarian cancer with conventional and contrast-enhanced transvaginal sonography: recent advances and potential improvements.

Fleischer AC, Lyshchik A, Hirari M, Moore RD, Abramson RG, Fishman DA - J Oncol (2012)

Bottom Line: These include improved assessment of tumor morphology with transvaginal sonography (TVS), and detection and characterization of tumor neovascularity with transvaginal color Doppler sonography (TV-CDS) and contrast-enhanced transvaginal sonography (CE-TVS).This paper will discuss and illustrate these improvements and describe how they enhance detection of early-stage ovarian cancer.Our initial experience with parametric mapping of CE-TVS will also be mentioned.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, 37232 Nashville, TN, USA.

ABSTRACT
Recently, there have been several major technical advances in the sonographic diagnosis of ovarian cancer in its early stages. These include improved assessment of tumor morphology with transvaginal sonography (TVS), and detection and characterization of tumor neovascularity with transvaginal color Doppler sonography (TV-CDS) and contrast-enhanced transvaginal sonography (CE-TVS). This paper will discuss and illustrate these improvements and describe how they enhance detection of early-stage ovarian cancer. Our initial experience with parametric mapping of CE-TVS will also be mentioned.

No MeSH data available.


Related in: MedlinePlus

CE-TVS of borderline mucinous (intestinal) cystadenocarcinoma.
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Related In: Results  -  Collection


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fig7: CE-TVS of borderline mucinous (intestinal) cystadenocarcinoma.

Mentions: CE-TVS can detect tumor neovascularity (Figures 4, 5, 6, 7, and 8). Tumor neovascularity is characterized by vessels with abnormal endothelial structure that are irregular in caliber and branching patterns. In order to recognize these features, contrast enhancement kinetics show relatively high vascular volume (AUC) and PE. These parameters seem to be best depicted using time-intensity curves. These parameters may also be shown in a parametric map, which allows for stricter cutoff criterion than ROI analysis, as peak values are visualized on a much finer scale than typical ROIs. The traditional approach of calculating the time-intensity curve over ROIs chosen on morphology alone allows small areas of neovascularity to be missed, as they are averaged over larger heterogeneous areas. The primary utility of parametric mapping of ovarian tumors may be guiding selection of ROIs to the area of greatest malignant potential.


Early detection of ovarian cancer with conventional and contrast-enhanced transvaginal sonography: recent advances and potential improvements.

Fleischer AC, Lyshchik A, Hirari M, Moore RD, Abramson RG, Fishman DA - J Oncol (2012)

CE-TVS of borderline mucinous (intestinal) cystadenocarcinoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3351123&req=5

fig7: CE-TVS of borderline mucinous (intestinal) cystadenocarcinoma.
Mentions: CE-TVS can detect tumor neovascularity (Figures 4, 5, 6, 7, and 8). Tumor neovascularity is characterized by vessels with abnormal endothelial structure that are irregular in caliber and branching patterns. In order to recognize these features, contrast enhancement kinetics show relatively high vascular volume (AUC) and PE. These parameters seem to be best depicted using time-intensity curves. These parameters may also be shown in a parametric map, which allows for stricter cutoff criterion than ROI analysis, as peak values are visualized on a much finer scale than typical ROIs. The traditional approach of calculating the time-intensity curve over ROIs chosen on morphology alone allows small areas of neovascularity to be missed, as they are averaged over larger heterogeneous areas. The primary utility of parametric mapping of ovarian tumors may be guiding selection of ROIs to the area of greatest malignant potential.

Bottom Line: These include improved assessment of tumor morphology with transvaginal sonography (TVS), and detection and characterization of tumor neovascularity with transvaginal color Doppler sonography (TV-CDS) and contrast-enhanced transvaginal sonography (CE-TVS).This paper will discuss and illustrate these improvements and describe how they enhance detection of early-stage ovarian cancer.Our initial experience with parametric mapping of CE-TVS will also be mentioned.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, 37232 Nashville, TN, USA.

ABSTRACT
Recently, there have been several major technical advances in the sonographic diagnosis of ovarian cancer in its early stages. These include improved assessment of tumor morphology with transvaginal sonography (TVS), and detection and characterization of tumor neovascularity with transvaginal color Doppler sonography (TV-CDS) and contrast-enhanced transvaginal sonography (CE-TVS). This paper will discuss and illustrate these improvements and describe how they enhance detection of early-stage ovarian cancer. Our initial experience with parametric mapping of CE-TVS will also be mentioned.

No MeSH data available.


Related in: MedlinePlus