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Abnormal cortical sensorimotor activity during "Target" sound detection in subjects with acute acoustic trauma sequelae: an fMRI study.

Job A, Pons Y, Lamalle L, Jaillard A, Buck K, Segebarth C, Delon-Martin C - Brain Behav (2012)

Bottom Line: In this study, we have used functional Magnetic Resonance Imaging (fMRI) to visualize neuronal activation patterns in military adults with AAT and various tinnitus sequelae during an auditory "oddball" attention task.AAT subjects displayed overactivities principally during reflex of target sound detection, in sensorimotor areas and in emotion-related areas such as the insula, anterior cingulate and prefrontal cortex, in premotor area, in cross-modal sensory associative areas, and, interestingly, in a region of the Rolandic operculum that has recently been shown to be involved in tympanic movements due to air pressure.We propose further investigations of this brain area and fine middle ear investigations, because our results might suggest a model in which AAT tinnitus may arise as a proprioceptive illusion caused by abnormal excitability of middle-ear muscle spindles possibly link with the acoustic reflex and associated with emotional and sensorimotor disturbances.

View Article: PubMed Central - PubMed

ABSTRACT
The most common consequences of acute acoustic trauma (AAT) are hearing loss at frequencies above 3 kHz and tinnitus. In this study, we have used functional Magnetic Resonance Imaging (fMRI) to visualize neuronal activation patterns in military adults with AAT and various tinnitus sequelae during an auditory "oddball" attention task. AAT subjects displayed overactivities principally during reflex of target sound detection, in sensorimotor areas and in emotion-related areas such as the insula, anterior cingulate and prefrontal cortex, in premotor area, in cross-modal sensory associative areas, and, interestingly, in a region of the Rolandic operculum that has recently been shown to be involved in tympanic movements due to air pressure. We propose further investigations of this brain area and fine middle ear investigations, because our results might suggest a model in which AAT tinnitus may arise as a proprioceptive illusion caused by abnormal excitability of middle-ear muscle spindles possibly link with the acoustic reflex and associated with emotional and sensorimotor disturbances.

No MeSH data available.


Related in: MedlinePlus

Hyperactivation in the Rolandic operculum (BA 43/40) in the AAT group during auditory oddball task (red voxels) for the contrast “Target sound vs. baseline” with superimposition of cortical activations in BA 43 found in Job et al. (2011) study for the contrast “tympanic movement due to air pressure variations vs. no pressure variations” in normal hearing subjects (green voxels).
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fig05: Hyperactivation in the Rolandic operculum (BA 43/40) in the AAT group during auditory oddball task (red voxels) for the contrast “Target sound vs. baseline” with superimposition of cortical activations in BA 43 found in Job et al. (2011) study for the contrast “tympanic movement due to air pressure variations vs. no pressure variations” in normal hearing subjects (green voxels).

Mentions: We have recently localized the cortical representation of the middle-ear superficial proprioception (i.e., small movements of tympanic membrane due to variations of pressure) in a specific limited region of Brodmann area 43 at the caudal edge of the somatosensory cortex (Job et al. 2011). The superposition of the cortical representation of tympanic membrane movement due to air pressure variation in BA 43 (green voxels) and of the hyperactivations found in the present study in BA 43 and BA43/40 (red voxels) shows that these regions are very close (Fig. 5). The hyperactivity zone observed in AAT subjects (red voxels) extended more deeply within the lateral sulcus than the hyperactivity caused by tympanic movement.


Abnormal cortical sensorimotor activity during "Target" sound detection in subjects with acute acoustic trauma sequelae: an fMRI study.

Job A, Pons Y, Lamalle L, Jaillard A, Buck K, Segebarth C, Delon-Martin C - Brain Behav (2012)

Hyperactivation in the Rolandic operculum (BA 43/40) in the AAT group during auditory oddball task (red voxels) for the contrast “Target sound vs. baseline” with superimposition of cortical activations in BA 43 found in Job et al. (2011) study for the contrast “tympanic movement due to air pressure variations vs. no pressure variations” in normal hearing subjects (green voxels).
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3345361&req=5

fig05: Hyperactivation in the Rolandic operculum (BA 43/40) in the AAT group during auditory oddball task (red voxels) for the contrast “Target sound vs. baseline” with superimposition of cortical activations in BA 43 found in Job et al. (2011) study for the contrast “tympanic movement due to air pressure variations vs. no pressure variations” in normal hearing subjects (green voxels).
Mentions: We have recently localized the cortical representation of the middle-ear superficial proprioception (i.e., small movements of tympanic membrane due to variations of pressure) in a specific limited region of Brodmann area 43 at the caudal edge of the somatosensory cortex (Job et al. 2011). The superposition of the cortical representation of tympanic membrane movement due to air pressure variation in BA 43 (green voxels) and of the hyperactivations found in the present study in BA 43 and BA43/40 (red voxels) shows that these regions are very close (Fig. 5). The hyperactivity zone observed in AAT subjects (red voxels) extended more deeply within the lateral sulcus than the hyperactivity caused by tympanic movement.

Bottom Line: In this study, we have used functional Magnetic Resonance Imaging (fMRI) to visualize neuronal activation patterns in military adults with AAT and various tinnitus sequelae during an auditory "oddball" attention task.AAT subjects displayed overactivities principally during reflex of target sound detection, in sensorimotor areas and in emotion-related areas such as the insula, anterior cingulate and prefrontal cortex, in premotor area, in cross-modal sensory associative areas, and, interestingly, in a region of the Rolandic operculum that has recently been shown to be involved in tympanic movements due to air pressure.We propose further investigations of this brain area and fine middle ear investigations, because our results might suggest a model in which AAT tinnitus may arise as a proprioceptive illusion caused by abnormal excitability of middle-ear muscle spindles possibly link with the acoustic reflex and associated with emotional and sensorimotor disturbances.

View Article: PubMed Central - PubMed

ABSTRACT
The most common consequences of acute acoustic trauma (AAT) are hearing loss at frequencies above 3 kHz and tinnitus. In this study, we have used functional Magnetic Resonance Imaging (fMRI) to visualize neuronal activation patterns in military adults with AAT and various tinnitus sequelae during an auditory "oddball" attention task. AAT subjects displayed overactivities principally during reflex of target sound detection, in sensorimotor areas and in emotion-related areas such as the insula, anterior cingulate and prefrontal cortex, in premotor area, in cross-modal sensory associative areas, and, interestingly, in a region of the Rolandic operculum that has recently been shown to be involved in tympanic movements due to air pressure. We propose further investigations of this brain area and fine middle ear investigations, because our results might suggest a model in which AAT tinnitus may arise as a proprioceptive illusion caused by abnormal excitability of middle-ear muscle spindles possibly link with the acoustic reflex and associated with emotional and sensorimotor disturbances.

No MeSH data available.


Related in: MedlinePlus