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Abnormal cortical sensorimotor activity during "Target" sound detection in subjects with acute acoustic trauma sequelae: an fMRI study.

Job A, Pons Y, Lamalle L, Jaillard A, Buck K, Segebarth C, Delon-Martin C - Brain Behav (2012)

Bottom Line: In this study, we have used functional Magnetic Resonance Imaging (fMRI) to visualize neuronal activation patterns in military adults with AAT and various tinnitus sequelae during an auditory "oddball" attention task.AAT subjects displayed overactivities principally during reflex of target sound detection, in sensorimotor areas and in emotion-related areas such as the insula, anterior cingulate and prefrontal cortex, in premotor area, in cross-modal sensory associative areas, and, interestingly, in a region of the Rolandic operculum that has recently been shown to be involved in tympanic movements due to air pressure.We propose further investigations of this brain area and fine middle ear investigations, because our results might suggest a model in which AAT tinnitus may arise as a proprioceptive illusion caused by abnormal excitability of middle-ear muscle spindles possibly link with the acoustic reflex and associated with emotional and sensorimotor disturbances.

View Article: PubMed Central - PubMed

ABSTRACT
The most common consequences of acute acoustic trauma (AAT) are hearing loss at frequencies above 3 kHz and tinnitus. In this study, we have used functional Magnetic Resonance Imaging (fMRI) to visualize neuronal activation patterns in military adults with AAT and various tinnitus sequelae during an auditory "oddball" attention task. AAT subjects displayed overactivities principally during reflex of target sound detection, in sensorimotor areas and in emotion-related areas such as the insula, anterior cingulate and prefrontal cortex, in premotor area, in cross-modal sensory associative areas, and, interestingly, in a region of the Rolandic operculum that has recently been shown to be involved in tympanic movements due to air pressure. We propose further investigations of this brain area and fine middle ear investigations, because our results might suggest a model in which AAT tinnitus may arise as a proprioceptive illusion caused by abnormal excitability of middle-ear muscle spindles possibly link with the acoustic reflex and associated with emotional and sensorimotor disturbances.

No MeSH data available.


Related in: MedlinePlus

Behavioral auditory task results in the AAT group and in control group. Task was performed in the audiolab and in the MR scanner. Intrasubject reaction-time variability and error rate were significantly higher in the AAT group.
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fig02: Behavioral auditory task results in the AAT group and in control group. Task was performed in the audiolab and in the MR scanner. Intrasubject reaction-time variability and error rate were significantly higher in the AAT group.

Mentions: Behavioral results of the auditory “oddball” task are shown in Figure 2. Mean reaction times were not significantly different between groups either in the audio laboratory or in the MR scanner. However, the mean intrasubject variability of the reaction times in AAT subjects was significantly larger than in controls, both in the laboratory (P = 0.017) and in the MR scanner (P = 0.030). The responses of the AAT, but not of the control subjects were affected in MRI conditions, as indicated by a significantly increased error rate (P = 0.012). Nevertheless, the error rate was lower than 10% in all conditions in both groups.


Abnormal cortical sensorimotor activity during "Target" sound detection in subjects with acute acoustic trauma sequelae: an fMRI study.

Job A, Pons Y, Lamalle L, Jaillard A, Buck K, Segebarth C, Delon-Martin C - Brain Behav (2012)

Behavioral auditory task results in the AAT group and in control group. Task was performed in the audiolab and in the MR scanner. Intrasubject reaction-time variability and error rate were significantly higher in the AAT group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3345361&req=5

fig02: Behavioral auditory task results in the AAT group and in control group. Task was performed in the audiolab and in the MR scanner. Intrasubject reaction-time variability and error rate were significantly higher in the AAT group.
Mentions: Behavioral results of the auditory “oddball” task are shown in Figure 2. Mean reaction times were not significantly different between groups either in the audio laboratory or in the MR scanner. However, the mean intrasubject variability of the reaction times in AAT subjects was significantly larger than in controls, both in the laboratory (P = 0.017) and in the MR scanner (P = 0.030). The responses of the AAT, but not of the control subjects were affected in MRI conditions, as indicated by a significantly increased error rate (P = 0.012). Nevertheless, the error rate was lower than 10% in all conditions in both groups.

Bottom Line: In this study, we have used functional Magnetic Resonance Imaging (fMRI) to visualize neuronal activation patterns in military adults with AAT and various tinnitus sequelae during an auditory "oddball" attention task.AAT subjects displayed overactivities principally during reflex of target sound detection, in sensorimotor areas and in emotion-related areas such as the insula, anterior cingulate and prefrontal cortex, in premotor area, in cross-modal sensory associative areas, and, interestingly, in a region of the Rolandic operculum that has recently been shown to be involved in tympanic movements due to air pressure.We propose further investigations of this brain area and fine middle ear investigations, because our results might suggest a model in which AAT tinnitus may arise as a proprioceptive illusion caused by abnormal excitability of middle-ear muscle spindles possibly link with the acoustic reflex and associated with emotional and sensorimotor disturbances.

View Article: PubMed Central - PubMed

ABSTRACT
The most common consequences of acute acoustic trauma (AAT) are hearing loss at frequencies above 3 kHz and tinnitus. In this study, we have used functional Magnetic Resonance Imaging (fMRI) to visualize neuronal activation patterns in military adults with AAT and various tinnitus sequelae during an auditory "oddball" attention task. AAT subjects displayed overactivities principally during reflex of target sound detection, in sensorimotor areas and in emotion-related areas such as the insula, anterior cingulate and prefrontal cortex, in premotor area, in cross-modal sensory associative areas, and, interestingly, in a region of the Rolandic operculum that has recently been shown to be involved in tympanic movements due to air pressure. We propose further investigations of this brain area and fine middle ear investigations, because our results might suggest a model in which AAT tinnitus may arise as a proprioceptive illusion caused by abnormal excitability of middle-ear muscle spindles possibly link with the acoustic reflex and associated with emotional and sensorimotor disturbances.

No MeSH data available.


Related in: MedlinePlus