Influenza research database: an integrated bioinformatics resource for influenza research and surveillance.
Bottom Line: IRD integrates genomic, proteomic, immune epitope, and surveillance data from a variety of sources, including public databases, computational algorithms, external research groups, and the scientific literature.To demonstrate the utility of the data and analysis tools available in IRD, two scientific use cases are presented.A comparison of hemagglutinin sequence conservation and epitope coverage information revealed highly conserved protein regions that can be recognized by the human adaptive immune system as possible targets for inducing cross-protective immunity.
Affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.Show MeSH
Related in: MedlinePlus
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Mentions: One of the more significant, distinguishing aspects of the IRD in comparison with other influenza resources is the availability of avian and non-human mammalian surveillance data. Surveillance data can be searched by various host and surveillance sample characteristics (Figure 5) with the results returned in the form of a surveillance record list or a custom summary table that enables users to compare up to four characteristics in a two-dimensional table. Characteristics that can be compared include host taxonomy, age and health status, sample influenza test results, isolation location and date, and virus subtype. The IRD surveillance records include precise geospatial location in the form of latitude and longitude coordinates, which allows visualization of the surveillance locations on a Google Map (Figure 6). Spatial coordinates also allow surveillance records to be mapped relative to other geospatial entities, such as bird migratory flyways.
Affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.