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Tissue factor expression in the symptomatic carotid plaque.

Abdul-Jabar H, Rashid A, Sadri A, Paes T - J Clin Med Res (2009)

Bottom Line: Areas of staining for the cap and core were analysed using the analySIS computer programme.There were 37 patients, of whom 27 were male with a mean age 69.3 years and a range of 53 to 83 years.More research is needed in this important area.

View Article: PubMed Central - PubMed

Affiliation: Department of Vascular Surgery, The Hillingdon Hospital, Pield Heath Road, Uxbridge, Middlesex UB8 3NN, UK.

ABSTRACT

Background: The aims of this study were to identify that the differences in the natural history of patients with symptomatic and asymptomatic carotid stenosis may be reflected in differences in the expression of procoagulant protein factors.

Methods: Carotid artery plaques were obtained from 33 symptomatic and 4 asymptomatic patients with internal carotid artery stenosis of greater than 70%. These plaques were stained with monoclonal antibody against human tissue factor. Areas of staining for the cap and core were analysed using the analySIS computer programme.

Results: There were 37 patients, of whom 27 were male with a mean age 69.3 years and a range of 53 to 83 years. Statistical analysis using non-parametric tests revealed a significant increase in the area of positive staining for tissue factor in plaques taken from symptomatic patients when compared to those who were asymptomatic (P = 0001). Within the symptomatic patients group there was significantly increased tissue factor in the plaque core of those who were the most recently symptomatic (P = 0.003).

Conclusions: The unstable carotid artery plaque is associated with significantly increased tissue factor expression in the cap and core. Plaques from the most recently symptomatic patients have significantly more tissue factor in the core and this may represent part of the mechanism responsible for plaque destabilisation. More research is needed in this important area.

Keywords: Tissue Factor; Carotid stenosis; Stroke; Plaque stability.

No MeSH data available.


Related in: MedlinePlus

Box and Whisker plots, which show, increased TF Expression in the Plaque Cores of the most recently Symptomatic Patients.
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Figure 5: Box and Whisker plots, which show, increased TF Expression in the Plaque Cores of the most recently Symptomatic Patients.

Mentions: The patients were then divided into groups according to the length of time between the last acute event and the CEA. Using the Kruskal-Wallis non-parametric test (Table 3); the expression of TF in the core was shown to be significantly increased in plaques from the most recently symptomatic patients. (Fig. 5).


Tissue factor expression in the symptomatic carotid plaque.

Abdul-Jabar H, Rashid A, Sadri A, Paes T - J Clin Med Res (2009)

Box and Whisker plots, which show, increased TF Expression in the Plaque Cores of the most recently Symptomatic Patients.
© Copyright Policy - open access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3318876&req=5

Figure 5: Box and Whisker plots, which show, increased TF Expression in the Plaque Cores of the most recently Symptomatic Patients.
Mentions: The patients were then divided into groups according to the length of time between the last acute event and the CEA. Using the Kruskal-Wallis non-parametric test (Table 3); the expression of TF in the core was shown to be significantly increased in plaques from the most recently symptomatic patients. (Fig. 5).

Bottom Line: Areas of staining for the cap and core were analysed using the analySIS computer programme.There were 37 patients, of whom 27 were male with a mean age 69.3 years and a range of 53 to 83 years.More research is needed in this important area.

View Article: PubMed Central - PubMed

Affiliation: Department of Vascular Surgery, The Hillingdon Hospital, Pield Heath Road, Uxbridge, Middlesex UB8 3NN, UK.

ABSTRACT

Background: The aims of this study were to identify that the differences in the natural history of patients with symptomatic and asymptomatic carotid stenosis may be reflected in differences in the expression of procoagulant protein factors.

Methods: Carotid artery plaques were obtained from 33 symptomatic and 4 asymptomatic patients with internal carotid artery stenosis of greater than 70%. These plaques were stained with monoclonal antibody against human tissue factor. Areas of staining for the cap and core were analysed using the analySIS computer programme.

Results: There were 37 patients, of whom 27 were male with a mean age 69.3 years and a range of 53 to 83 years. Statistical analysis using non-parametric tests revealed a significant increase in the area of positive staining for tissue factor in plaques taken from symptomatic patients when compared to those who were asymptomatic (P = 0001). Within the symptomatic patients group there was significantly increased tissue factor in the plaque core of those who were the most recently symptomatic (P = 0.003).

Conclusions: The unstable carotid artery plaque is associated with significantly increased tissue factor expression in the cap and core. Plaques from the most recently symptomatic patients have significantly more tissue factor in the core and this may represent part of the mechanism responsible for plaque destabilisation. More research is needed in this important area.

Keywords: Tissue Factor; Carotid stenosis; Stroke; Plaque stability.

No MeSH data available.


Related in: MedlinePlus