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Lactoferrin levels in the gastric tissue of Helicobacter pylori-positive and -negative patients and its effect on anemia.

Doğan Y, Erkan T, Önal Z, Usta M, Doğusoy G, Çokuğraş FÇ, Kutlu T - Mediators Inflamm. (2012)

Bottom Line: Hp-negative cases showed significantly different values of 17.8 ± 4.5% and 1.3 ± 0.2, respectively.Tissue Lf was significantly higher in Hp-positive cases compared to Hp-negative cases, but no difference was observed between the two groups with regards to hemoglobin and ferritin level.As a result, it is difficult to say that this rise in Lf plays a role in the development of iron deficiency anemia in Hp-positive patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Pediatric Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Cerrahpaşa Medical Faculty, İstanbul University, İstanbul 23119, Turkey. yasardogan@ttmail.com

ABSTRACT

Aim: To determine gastric tissue lactoferrin (Lf) levels of Helicobacter pylori- (Hp-) positive and -negative patients and its effect on anemia.

Methods: Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided into two groups.

Results: The study included 64 cases (average: 10.2 ± 0.4 years, 39 male and 25 female). Lf levels were subsequently studied on 61 cases. 45 (73.8%) of these were Hp-positive, while 16 (22.2%) were Hp-negative. In Hp-positive cases, mean staining percentages and density of glands in the antral mucosa were 45.5 ± 4.7% and 1.9 ± 0.1, respectively. Hp-negative cases showed significantly different values of 17.8 ± 4.5% and 1.3 ± 0.2, respectively. Hemoglobin and serum ferritin values of Hp-positive cases were 12.7 ± 0.2 g/dL and 32.5 ± 2 ng/mL, but these were comparable with Hp-negative cases (12.6 ± 0.1 g/dL and 30.7 ± 4.4 ng/mL).

Conclusions: Tissue Lf was significantly higher in Hp-positive cases compared to Hp-negative cases, but no difference was observed between the two groups with regards to hemoglobin and ferritin level. As a result, it is difficult to say that this rise in Lf plays a role in the development of iron deficiency anemia in Hp-positive patients.

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Staining density of antral mucosal glands by Hp-positive and -negative cases.
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fig2: Staining density of antral mucosal glands by Hp-positive and -negative cases.

Mentions: As three cases had insufficient tissue for assay, tissue Lf was only measured in the remaining 61 cases. 45 of these cases were Hp-positive, while 16 were Hp-negative. In Hp positive cases, staining percentages and density of glands in the antral mucosa were 45.5 ± 4.7% and 1.9 ± 0.1, respectively, while these figures were 17.8 ± 4.5% and 1.3 ± 0.2 [(P = 0.001, CI = 0.0–0.048), (P = 0.016, CI = 0.0–0.048)] in Hp-negative cases. (Figures 1 and 2). The neutrophil density in the Hp-positive group was also significantly higher compared to the Hp-negative group. (P = 0.001, CI = 0.0–0.046) (Figure 3).


Lactoferrin levels in the gastric tissue of Helicobacter pylori-positive and -negative patients and its effect on anemia.

Doğan Y, Erkan T, Önal Z, Usta M, Doğusoy G, Çokuğraş FÇ, Kutlu T - Mediators Inflamm. (2012)

Staining density of antral mucosal glands by Hp-positive and -negative cases.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3316978&req=5

fig2: Staining density of antral mucosal glands by Hp-positive and -negative cases.
Mentions: As three cases had insufficient tissue for assay, tissue Lf was only measured in the remaining 61 cases. 45 of these cases were Hp-positive, while 16 were Hp-negative. In Hp positive cases, staining percentages and density of glands in the antral mucosa were 45.5 ± 4.7% and 1.9 ± 0.1, respectively, while these figures were 17.8 ± 4.5% and 1.3 ± 0.2 [(P = 0.001, CI = 0.0–0.048), (P = 0.016, CI = 0.0–0.048)] in Hp-negative cases. (Figures 1 and 2). The neutrophil density in the Hp-positive group was also significantly higher compared to the Hp-negative group. (P = 0.001, CI = 0.0–0.046) (Figure 3).

Bottom Line: Hp-negative cases showed significantly different values of 17.8 ± 4.5% and 1.3 ± 0.2, respectively.Tissue Lf was significantly higher in Hp-positive cases compared to Hp-negative cases, but no difference was observed between the two groups with regards to hemoglobin and ferritin level.As a result, it is difficult to say that this rise in Lf plays a role in the development of iron deficiency anemia in Hp-positive patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Pediatric Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Cerrahpaşa Medical Faculty, İstanbul University, İstanbul 23119, Turkey. yasardogan@ttmail.com

ABSTRACT

Aim: To determine gastric tissue lactoferrin (Lf) levels of Helicobacter pylori- (Hp-) positive and -negative patients and its effect on anemia.

Methods: Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided into two groups.

Results: The study included 64 cases (average: 10.2 ± 0.4 years, 39 male and 25 female). Lf levels were subsequently studied on 61 cases. 45 (73.8%) of these were Hp-positive, while 16 (22.2%) were Hp-negative. In Hp-positive cases, mean staining percentages and density of glands in the antral mucosa were 45.5 ± 4.7% and 1.9 ± 0.1, respectively. Hp-negative cases showed significantly different values of 17.8 ± 4.5% and 1.3 ± 0.2, respectively. Hemoglobin and serum ferritin values of Hp-positive cases were 12.7 ± 0.2 g/dL and 32.5 ± 2 ng/mL, but these were comparable with Hp-negative cases (12.6 ± 0.1 g/dL and 30.7 ± 4.4 ng/mL).

Conclusions: Tissue Lf was significantly higher in Hp-positive cases compared to Hp-negative cases, but no difference was observed between the two groups with regards to hemoglobin and ferritin level. As a result, it is difficult to say that this rise in Lf plays a role in the development of iron deficiency anemia in Hp-positive patients.

Show MeSH
Related in: MedlinePlus