Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.
Bottom Line: Asp358Ala was not associated with lipid concentrations, blood pressure, adiposity, dysglycaemia, or smoking (p value for association per minor allele ≥0·04 for each).By contrast, for every copy of 358Ala inherited, mean concentration of IL6R increased by 34·3% (95% CI 30·4-38·2) and of interleukin 6 by 14·6% (10·7-18·4), and mean concentration of C-reactive protein was reduced by 7·5% (5·9-9·1) and of fibrinogen by 1·0% (0·7-1·3).Asp358Ala was not related to IL6R mRNA levels or interleukin-6 production in monocytes.
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Mentions: Among people with no history of cardiovascular disease at the time of blood sampling, circulating concentrations of interleukin 6, C-reactive protein, and fibrinogen were each positively associated with one another (figure 3A). The age-adjusted and sex-adjusted partial correlation coefficient was 0·49 (95% CI 0·46–0·52) between loge interleukin 6 and loge C-reactive protein, 0·35 (0·31–0·39) between loge interleukin 6 and fibrinogen, and 0·48 (0·45–0·50) between loge C-reactive protein and fibrinogen. There were roughly log-linear associations between baseline concentrations of each of interleukin 6, C-reactive protein, and fibrinogen and subsequent risk of coronary heart disease (figure 3B).