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Cardiac biomarkers in the intensive care unit.

McLean AS, Huang SJ - Ann Intensive Care (2012)

Bottom Line: With the better understanding of the CB properties, CB can now help detecting various acute processes such as pulmonary embolism, sepsis-related myocardial depression, acute heart failure, renal failure and acute lung injury.This article discusses the properties and the uses of common CB, with special reference to the intensive care setting.The potential utility of "multimarkers" approach and microRNA as the future CB are also briefly discussed.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Intensive Care Medicine, Nepean Hospital, Sydney Medical School, Penrith, NSW 2750, Australia. anthony.mclean@sydney.edu.au.

ABSTRACT
Cardiac biomarkers (CB) were first developed for assisting the diagnosis of cardiac events, especially acute myocardial infarction. The discoveries of other CB, the better understanding of cardiac disease process and the advancement in detection technology has pushed the applications of CB beyond the 'diagnosis' boundary. Not only the measurements of CB are more sensitive, the applications have now covered staging of cardiac disease, timing of cardiac events and prognostication. Further, CB have made their way to the intensive care setting where their uses are not just confined to cardiac related areas. With the better understanding of the CB properties, CB can now help detecting various acute processes such as pulmonary embolism, sepsis-related myocardial depression, acute heart failure, renal failure and acute lung injury. This article discusses the properties and the uses of common CB, with special reference to the intensive care setting. The potential utility of "multimarkers" approach and microRNA as the future CB are also briefly discussed.

No MeSH data available.


Related in: MedlinePlus

Evolution of cardiac dysfunction and the associated changes in cardiac biomarkers. (see legend to Figure 1 for abbreviations).
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Related In: Results  -  Collection

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Figure 2: Evolution of cardiac dysfunction and the associated changes in cardiac biomarkers. (see legend to Figure 1 for abbreviations).

Mentions: The search for clinically useful CB has resulted in a large number of circulating plasma substances being investigated. These can be broadly grouped temporally into three major categories: inflammatory, acute muscle injury, and cardiac stress (Figure 2).


Cardiac biomarkers in the intensive care unit.

McLean AS, Huang SJ - Ann Intensive Care (2012)

Evolution of cardiac dysfunction and the associated changes in cardiac biomarkers. (see legend to Figure 1 for abbreviations).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3313856&req=5

Figure 2: Evolution of cardiac dysfunction and the associated changes in cardiac biomarkers. (see legend to Figure 1 for abbreviations).
Mentions: The search for clinically useful CB has resulted in a large number of circulating plasma substances being investigated. These can be broadly grouped temporally into three major categories: inflammatory, acute muscle injury, and cardiac stress (Figure 2).

Bottom Line: With the better understanding of the CB properties, CB can now help detecting various acute processes such as pulmonary embolism, sepsis-related myocardial depression, acute heart failure, renal failure and acute lung injury.This article discusses the properties and the uses of common CB, with special reference to the intensive care setting.The potential utility of "multimarkers" approach and microRNA as the future CB are also briefly discussed.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Intensive Care Medicine, Nepean Hospital, Sydney Medical School, Penrith, NSW 2750, Australia. anthony.mclean@sydney.edu.au.

ABSTRACT
Cardiac biomarkers (CB) were first developed for assisting the diagnosis of cardiac events, especially acute myocardial infarction. The discoveries of other CB, the better understanding of cardiac disease process and the advancement in detection technology has pushed the applications of CB beyond the 'diagnosis' boundary. Not only the measurements of CB are more sensitive, the applications have now covered staging of cardiac disease, timing of cardiac events and prognostication. Further, CB have made their way to the intensive care setting where their uses are not just confined to cardiac related areas. With the better understanding of the CB properties, CB can now help detecting various acute processes such as pulmonary embolism, sepsis-related myocardial depression, acute heart failure, renal failure and acute lung injury. This article discusses the properties and the uses of common CB, with special reference to the intensive care setting. The potential utility of "multimarkers" approach and microRNA as the future CB are also briefly discussed.

No MeSH data available.


Related in: MedlinePlus