Limits...
A descriptive study of hyponatremia in a tertiary care hospital of Eastern India.

Chatterjee N, Sengupta N, Das C, Chowdhuri AR, Basu AK, Pal SK - Indian J Endocrinol Metab (2012)

Bottom Line: This was followed by a plasma and urinary osmolality determination (osmometer 800 CL) as well as urinary sodium estimation.Sixty-six patients fulfilled the criteria for SIADH.During the hospital stay, 13.5% (15/201) hyponatremic patients died, while the corresponding figure in normonatremic patients was 8.5% (87/1020).

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, NRS Medical College, Kolkata, India.

ABSTRACT

Background: Hyponatremia is one of the commonest electrolyte disturbances encountered in medical wards and contributes to substantial morbidity and mortality. However, early recognition and management drastically alters prognosis. Therefore, this observational study was taken up to explore the clinical profile of hyponatremia.

Aim: To assess the incidence and clinical profile of hyponatremia in medically ill patients.

Materials and methods: This observational study was conducted in the medical ward of a tertiary care hospital from March 2010 to April 2011. All patients underwent routine hemogram, blood biochemistry, serum electrolytes, thyroid function tests, and morning serum cortisol estimation. This was followed by a plasma and urinary osmolality determination (osmometer 800 CL) as well as urinary sodium estimation. Patients were diagnosed to have syndrome of inappropriate antidiuretic hormone secretion (SIADH) if they satisfied the Bartter and Schwartz criteria.

Results: 201 patients (16.4%) had a serum Na < 135 meq/l. There were 126 (62.69%) male patients and 75 (37.31%) female patients. Severe hyponatremia (Na < 120 meq/l) was detected in 30 patients (2.4%). The largest group of hyponatremic patients were euvolemic [102 (50.74%)], followed by hypervolemic [54 (26.86%)] and hypovolemic [45 (22.4%)]. Sixty-six patients fulfilled the criteria for SIADH. The most common underlying predisposing factor for hyponatremia in our case series was fluid loss by vomiting/diarrhea. During the hospital stay, 13.5% (15/201) hyponatremic patients died, while the corresponding figure in normonatremic patients was 8.5% (87/1020).

Conclusion: The incidence of hyponatremia in our series was higher than values mostly reported in western literature. Euvolemic hyponatremia was the most common type, a significant fraction of which is SIADH.

No MeSH data available.


Related in: MedlinePlus

Volume status of hyponatremic patients
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3313751&req=5

Figure 2: Volume status of hyponatremic patients

Mentions: This study was conducted for a period of 1 year in our unit in the medical ward of tertiary care hospital in Eastern India. The total number of patients admitted in that period was 1221. Out of them, 201 patients (16.4%) had a serum Na of < 135 meq/l. There were 126 (62.69%) male patients and 75 (37.31%) female patients [Figure 1]. Severe hyponatremia (Na < 120 meq/l) was detected in 30 patients (2.4%). The mean sodium level was 126.34 meq/l. The largest group of hyponatremic patients were euvolemic [102 (50.74%)], followed by hypervolemic [54 (26.86%)] and hypovolemic [45 (22.4%)] [Figure 2]. Sixty-six patients fulfilled the criteria for SIADH.


A descriptive study of hyponatremia in a tertiary care hospital of Eastern India.

Chatterjee N, Sengupta N, Das C, Chowdhuri AR, Basu AK, Pal SK - Indian J Endocrinol Metab (2012)

Volume status of hyponatremic patients
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3313751&req=5

Figure 2: Volume status of hyponatremic patients
Mentions: This study was conducted for a period of 1 year in our unit in the medical ward of tertiary care hospital in Eastern India. The total number of patients admitted in that period was 1221. Out of them, 201 patients (16.4%) had a serum Na of < 135 meq/l. There were 126 (62.69%) male patients and 75 (37.31%) female patients [Figure 1]. Severe hyponatremia (Na < 120 meq/l) was detected in 30 patients (2.4%). The mean sodium level was 126.34 meq/l. The largest group of hyponatremic patients were euvolemic [102 (50.74%)], followed by hypervolemic [54 (26.86%)] and hypovolemic [45 (22.4%)] [Figure 2]. Sixty-six patients fulfilled the criteria for SIADH.

Bottom Line: This was followed by a plasma and urinary osmolality determination (osmometer 800 CL) as well as urinary sodium estimation.Sixty-six patients fulfilled the criteria for SIADH.During the hospital stay, 13.5% (15/201) hyponatremic patients died, while the corresponding figure in normonatremic patients was 8.5% (87/1020).

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, NRS Medical College, Kolkata, India.

ABSTRACT

Background: Hyponatremia is one of the commonest electrolyte disturbances encountered in medical wards and contributes to substantial morbidity and mortality. However, early recognition and management drastically alters prognosis. Therefore, this observational study was taken up to explore the clinical profile of hyponatremia.

Aim: To assess the incidence and clinical profile of hyponatremia in medically ill patients.

Materials and methods: This observational study was conducted in the medical ward of a tertiary care hospital from March 2010 to April 2011. All patients underwent routine hemogram, blood biochemistry, serum electrolytes, thyroid function tests, and morning serum cortisol estimation. This was followed by a plasma and urinary osmolality determination (osmometer 800 CL) as well as urinary sodium estimation. Patients were diagnosed to have syndrome of inappropriate antidiuretic hormone secretion (SIADH) if they satisfied the Bartter and Schwartz criteria.

Results: 201 patients (16.4%) had a serum Na < 135 meq/l. There were 126 (62.69%) male patients and 75 (37.31%) female patients. Severe hyponatremia (Na < 120 meq/l) was detected in 30 patients (2.4%). The largest group of hyponatremic patients were euvolemic [102 (50.74%)], followed by hypervolemic [54 (26.86%)] and hypovolemic [45 (22.4%)]. Sixty-six patients fulfilled the criteria for SIADH. The most common underlying predisposing factor for hyponatremia in our case series was fluid loss by vomiting/diarrhea. During the hospital stay, 13.5% (15/201) hyponatremic patients died, while the corresponding figure in normonatremic patients was 8.5% (87/1020).

Conclusion: The incidence of hyponatremia in our series was higher than values mostly reported in western literature. Euvolemic hyponatremia was the most common type, a significant fraction of which is SIADH.

No MeSH data available.


Related in: MedlinePlus