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Interactions between thyroid disorders and kidney disease.

Basu G, Mohapatra A - Indian J Endocrinol Metab (2012)

Bottom Line: Hypothyroidism is associated with reduced GFR and hyperthyroidism results in increased GFR as well as increased renin - angiotensin - aldosterone activation.Thyroid dysfunction is also associated with glomerulonephritis often by a common autoimmune etiology.A detailed knowledge of all these interactions is important for both the nephrologists and endocrinologists for optimal management of the patient.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology, Christian Medical College, Vellore, Tamil Nadu, India.

ABSTRACT
There are several interactions between thyroid and kidney functions in each other organ's disease states. Thyroid hormones affect renal development and physiology. Thyroid hormones have pre-renal and intrinsic renal effects by which they increase the renal blood flow and the glomerular filtration rate (GFR). Hypothyroidism is associated with reduced GFR and hyperthyroidism results in increased GFR as well as increased renin - angiotensin - aldosterone activation. Chronic kidney disease (CKD) is characterized by a low T3 syndrome which is now considered a part of an atypical nonthyroidal illness. CKD patients also have increased incidence of primary hypothyroidism and subclinical hypothyroidism. The physiological benefits of a hypothyroid state in CKD, and the risk of CKD progression with hyperthyroidism emphasize on a conservative approach in the treatment of thyroid hormone abnormalities in CKD. Thyroid dysfunction is also associated with glomerulonephritis often by a common autoimmune etiology. Several drugs could affect both thyroid and kidney functions. There are few described interactions between thyroid and renal malignancies. A detailed knowledge of all these interactions is important for both the nephrologists and endocrinologists for optimal management of the patient.

No MeSH data available.


Related in: MedlinePlus

Effects of hyperthyroidism and hypothyroidism on renal physiology and function
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Figure 1: Effects of hyperthyroidism and hypothyroidism on renal physiology and function

Mentions: Thyroid dysfunction affects RBF, GFR, tubular function, electrolyte homeostasis, and kidney structure. The various effects of hypothyroidism and hyperthyroidism on renal function have been summarized in Figure 1. The effects on renal function tests are listed in Table 1.


Interactions between thyroid disorders and kidney disease.

Basu G, Mohapatra A - Indian J Endocrinol Metab (2012)

Effects of hyperthyroidism and hypothyroidism on renal physiology and function
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3313737&req=5

Figure 1: Effects of hyperthyroidism and hypothyroidism on renal physiology and function
Mentions: Thyroid dysfunction affects RBF, GFR, tubular function, electrolyte homeostasis, and kidney structure. The various effects of hypothyroidism and hyperthyroidism on renal function have been summarized in Figure 1. The effects on renal function tests are listed in Table 1.

Bottom Line: Hypothyroidism is associated with reduced GFR and hyperthyroidism results in increased GFR as well as increased renin - angiotensin - aldosterone activation.Thyroid dysfunction is also associated with glomerulonephritis often by a common autoimmune etiology.A detailed knowledge of all these interactions is important for both the nephrologists and endocrinologists for optimal management of the patient.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology, Christian Medical College, Vellore, Tamil Nadu, India.

ABSTRACT
There are several interactions between thyroid and kidney functions in each other organ's disease states. Thyroid hormones affect renal development and physiology. Thyroid hormones have pre-renal and intrinsic renal effects by which they increase the renal blood flow and the glomerular filtration rate (GFR). Hypothyroidism is associated with reduced GFR and hyperthyroidism results in increased GFR as well as increased renin - angiotensin - aldosterone activation. Chronic kidney disease (CKD) is characterized by a low T3 syndrome which is now considered a part of an atypical nonthyroidal illness. CKD patients also have increased incidence of primary hypothyroidism and subclinical hypothyroidism. The physiological benefits of a hypothyroid state in CKD, and the risk of CKD progression with hyperthyroidism emphasize on a conservative approach in the treatment of thyroid hormone abnormalities in CKD. Thyroid dysfunction is also associated with glomerulonephritis often by a common autoimmune etiology. Several drugs could affect both thyroid and kidney functions. There are few described interactions between thyroid and renal malignancies. A detailed knowledge of all these interactions is important for both the nephrologists and endocrinologists for optimal management of the patient.

No MeSH data available.


Related in: MedlinePlus