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Lack of evidence for intermolecular epistatic interactions between adiponectin and resistin gene polymorphisms in Malaysian male subjects.

Lau CH, Muniandy S - Genet. Mol. Biol. (2011)

Bottom Line: The rare homozygous genotype (risk alleles) of SNP-420C > G at the RETN locus tended to be co-inherited together with the common homozygous genotypes (protective alleles) of SNP+639T > C and SNP+1212A > G at the ADIPOQ locus.Despite the close structural relationship between the ADIPOQ and RETN genes, there was no evidence of an intermolecular epistatic interaction between these genes.The possible influence of the ADIPOQ gene on RETN expression warrants further investigation.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

ABSTRACT
Epistasis (gene-gene interaction) is a ubiquitous component of the genetic architecture of complex traits such as susceptibility to common human diseases. Given the strong negative correlation between circulating adiponectin and resistin levels, the potential intermolecular epistatic interactions between ADIPOQ (SNP+45T > G, SNP+276G > T, SNP+639T > C and SNP+1212A > G) and RETN (SNP-420C > G and SNP+299G > A) gene polymorphisms in the genetic risk underlying type 2 diabetes (T2DM) and metabolic syndrome (MS) were assessed. The potential mutual influence of the ADIPOQ and RETN genes on their adipokine levels was also examined. The rare homozygous genotype (risk alleles) of SNP-420C > G at the RETN locus tended to be co-inherited together with the common homozygous genotypes (protective alleles) of SNP+639T > C and SNP+1212A > G at the ADIPOQ locus. Despite the close structural relationship between the ADIPOQ and RETN genes, there was no evidence of an intermolecular epistatic interaction between these genes. There was also no reciprocal effect of the ADIPOQ and RETN genes on their adipokine levels, i.e., ADIPOQ did not affect resistin levels nor did RETN affect adiponectin levels. The possible influence of the ADIPOQ gene on RETN expression warrants further investigation.

No MeSH data available.


Related in: MedlinePlus

Dimension reduction correspondence analysis of SNP+299G > A showing biplot results for (A) SNP+299G > A and SNP+45T > G, (B) SNP+299G > A and SNP+276G > T, (C) SNP+299G < A and SNP+639T > C and (D) SNP+299G > A and SNP+1212A > G. The total sample size was 809. See the legend for Figure 1 for details of the model settings and the interpretation of biplots. Note: RETN (SNP+299G > A); ADIPOQ (SNP+45T > G, SNP+276G > T, SNP+639T > C, SNP+1212A > G).
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f2-gmb-35-1-38: Dimension reduction correspondence analysis of SNP+299G > A showing biplot results for (A) SNP+299G > A and SNP+45T > G, (B) SNP+299G > A and SNP+276G > T, (C) SNP+299G < A and SNP+639T > C and (D) SNP+299G > A and SNP+1212A > G. The total sample size was 809. See the legend for Figure 1 for details of the model settings and the interpretation of biplots. Note: RETN (SNP+299G > A); ADIPOQ (SNP+45T > G, SNP+276G > T, SNP+639T > C, SNP+1212A > G).

Mentions: SNP-420C > G of the RETN gene showed a strong structural relationship with SNP+639T > C and SNP+1212A > G of the ADIPOQ gene (Figure 1). The heterozygous genotype of SNP-420C > G tended to be co-inherited together with the heterozygous genotypes of SNP+639T > C (Figure 1C) and SNP+1212A > G (Figure 1D). SNP+299G > A of the RETN gene shared a strong structural relationship with SNP+639T > C of the ADIPOQ gene (Figure 2). The common homozygous genotypes of SNP+299G > A and SNP+639T > C tended to be co-inherited (Figure 2C). Interestingly, the rare homozygous genotype of SNP-420C > G was generally co-inherited with the common homozygous genotypes of SNP+639T < C (Figure 1C) and SNP+1212A < G (Figure 1D). Furthermore, the rare homozygous genotypes of these SNPs at the ADIPOQ and RETN loci were unlikely to be co-inherited (Figures 1 and 2), which suggested a possible antagonistic relationship between the ADIPOQ and RETN genes.


Lack of evidence for intermolecular epistatic interactions between adiponectin and resistin gene polymorphisms in Malaysian male subjects.

Lau CH, Muniandy S - Genet. Mol. Biol. (2011)

Dimension reduction correspondence analysis of SNP+299G > A showing biplot results for (A) SNP+299G > A and SNP+45T > G, (B) SNP+299G > A and SNP+276G > T, (C) SNP+299G < A and SNP+639T > C and (D) SNP+299G > A and SNP+1212A > G. The total sample size was 809. See the legend for Figure 1 for details of the model settings and the interpretation of biplots. Note: RETN (SNP+299G > A); ADIPOQ (SNP+45T > G, SNP+276G > T, SNP+639T > C, SNP+1212A > G).
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Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3313514&req=5

f2-gmb-35-1-38: Dimension reduction correspondence analysis of SNP+299G > A showing biplot results for (A) SNP+299G > A and SNP+45T > G, (B) SNP+299G > A and SNP+276G > T, (C) SNP+299G < A and SNP+639T > C and (D) SNP+299G > A and SNP+1212A > G. The total sample size was 809. See the legend for Figure 1 for details of the model settings and the interpretation of biplots. Note: RETN (SNP+299G > A); ADIPOQ (SNP+45T > G, SNP+276G > T, SNP+639T > C, SNP+1212A > G).
Mentions: SNP-420C > G of the RETN gene showed a strong structural relationship with SNP+639T > C and SNP+1212A > G of the ADIPOQ gene (Figure 1). The heterozygous genotype of SNP-420C > G tended to be co-inherited together with the heterozygous genotypes of SNP+639T > C (Figure 1C) and SNP+1212A > G (Figure 1D). SNP+299G > A of the RETN gene shared a strong structural relationship with SNP+639T > C of the ADIPOQ gene (Figure 2). The common homozygous genotypes of SNP+299G > A and SNP+639T > C tended to be co-inherited (Figure 2C). Interestingly, the rare homozygous genotype of SNP-420C > G was generally co-inherited with the common homozygous genotypes of SNP+639T < C (Figure 1C) and SNP+1212A < G (Figure 1D). Furthermore, the rare homozygous genotypes of these SNPs at the ADIPOQ and RETN loci were unlikely to be co-inherited (Figures 1 and 2), which suggested a possible antagonistic relationship between the ADIPOQ and RETN genes.

Bottom Line: The rare homozygous genotype (risk alleles) of SNP-420C > G at the RETN locus tended to be co-inherited together with the common homozygous genotypes (protective alleles) of SNP+639T > C and SNP+1212A > G at the ADIPOQ locus.Despite the close structural relationship between the ADIPOQ and RETN genes, there was no evidence of an intermolecular epistatic interaction between these genes.The possible influence of the ADIPOQ gene on RETN expression warrants further investigation.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

ABSTRACT
Epistasis (gene-gene interaction) is a ubiquitous component of the genetic architecture of complex traits such as susceptibility to common human diseases. Given the strong negative correlation between circulating adiponectin and resistin levels, the potential intermolecular epistatic interactions between ADIPOQ (SNP+45T > G, SNP+276G > T, SNP+639T > C and SNP+1212A > G) and RETN (SNP-420C > G and SNP+299G > A) gene polymorphisms in the genetic risk underlying type 2 diabetes (T2DM) and metabolic syndrome (MS) were assessed. The potential mutual influence of the ADIPOQ and RETN genes on their adipokine levels was also examined. The rare homozygous genotype (risk alleles) of SNP-420C > G at the RETN locus tended to be co-inherited together with the common homozygous genotypes (protective alleles) of SNP+639T > C and SNP+1212A > G at the ADIPOQ locus. Despite the close structural relationship between the ADIPOQ and RETN genes, there was no evidence of an intermolecular epistatic interaction between these genes. There was also no reciprocal effect of the ADIPOQ and RETN genes on their adipokine levels, i.e., ADIPOQ did not affect resistin levels nor did RETN affect adiponectin levels. The possible influence of the ADIPOQ gene on RETN expression warrants further investigation.

No MeSH data available.


Related in: MedlinePlus