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Distribution of the CCR5delta32 allele (gene variant CCR5) in Rondônia, Western Amazonian region, Brazil.

de Farias JD, Santos MG, de França AK, Delani D, Tada MS, Casseb AA, Simões AL, Engracia V - Genet. Mol. Biol. (2012)

Bottom Line: Two homozygous individuals (CCR5Δ32/CCR5Δ32) were detected among the HB Mother samples.The frequency of this allele was heterogeneous and higher where the European inflow was more pronounced.The presence of the allele in Pedras Negras revealed European miscegenation in a community largely comprising Quilombolas.

View Article: PubMed Central - PubMed

Affiliation: Laboratório de Genética Humana, Instituto de Pesquisas em Patologias Tropicais, Porto Velho, RO, Brazil.

ABSTRACT
Since around 1723, on the occasion of its initial colonization by Europeans, Rondonia has received successive waves of immigrants. This has been further swelled by individuals from northeastern Brazil, who began entering at the beginning of the twentieth century. The ethnic composition varies across the state according to the various sites of settlement of each wave of immigrants. We analyzed the frequency of the CCR5Δ32 allele of the CCR5 chemokine receptor, which is considered a Caucasian marker, in five sample sets from the population. Four were collected in Porto Velho, the state capital and the site of several waves of migration. Of these, two, from the Hospital de Base were comprised of HB Mothers and HB Newborns presenting allele frequencies of 3.5% and 3.1%, respectively, a third from the peri-urban neighborhoods of Candelária/Bate-Estaca (1.8%), whereas a fourth, from the Research Center on Tropical Medicine/CEPEM (0.6%), was composed of malaria patients under treament. The fifth sample (3.4%) came from the inland Quilombola village of Pedras Negras. Two homozygous individuals (CCR5Δ32/CCR5Δ32) were detected among the HB Mother samples. The frequency of this allele was heterogeneous and higher where the European inflow was more pronounced. The presence of the allele in Pedras Negras revealed European miscegenation in a community largely comprising Quilombolas.

No MeSH data available.


Related in: MedlinePlus

Map of Brazil indicating the geographical location of the city of Porto Velho and that of the village of Pedras Negras.
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f1-gmb-35-1-27: Map of Brazil indicating the geographical location of the city of Porto Velho and that of the village of Pedras Negras.

Mentions: The study was carried out with samples collected in two regions of Rondônia, the city of Porto Velho (63°54′14″ W; 08°45′43″ S) and the rural village of Pedras Negras (62°54′ O; 12°51′ S). The first three were from Porto Velho, one from the city’s riverine region and the remainder from other locations. The fourth subsample was collected in the rural region of the state in the village of Pedras Negras, situated in the Guapore River valley. A map of the region is presented in Figure 1.


Distribution of the CCR5delta32 allele (gene variant CCR5) in Rondônia, Western Amazonian region, Brazil.

de Farias JD, Santos MG, de França AK, Delani D, Tada MS, Casseb AA, Simões AL, Engracia V - Genet. Mol. Biol. (2012)

Map of Brazil indicating the geographical location of the city of Porto Velho and that of the village of Pedras Negras.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3313512&req=5

f1-gmb-35-1-27: Map of Brazil indicating the geographical location of the city of Porto Velho and that of the village of Pedras Negras.
Mentions: The study was carried out with samples collected in two regions of Rondônia, the city of Porto Velho (63°54′14″ W; 08°45′43″ S) and the rural village of Pedras Negras (62°54′ O; 12°51′ S). The first three were from Porto Velho, one from the city’s riverine region and the remainder from other locations. The fourth subsample was collected in the rural region of the state in the village of Pedras Negras, situated in the Guapore River valley. A map of the region is presented in Figure 1.

Bottom Line: Two homozygous individuals (CCR5Δ32/CCR5Δ32) were detected among the HB Mother samples.The frequency of this allele was heterogeneous and higher where the European inflow was more pronounced.The presence of the allele in Pedras Negras revealed European miscegenation in a community largely comprising Quilombolas.

View Article: PubMed Central - PubMed

Affiliation: Laboratório de Genética Humana, Instituto de Pesquisas em Patologias Tropicais, Porto Velho, RO, Brazil.

ABSTRACT
Since around 1723, on the occasion of its initial colonization by Europeans, Rondonia has received successive waves of immigrants. This has been further swelled by individuals from northeastern Brazil, who began entering at the beginning of the twentieth century. The ethnic composition varies across the state according to the various sites of settlement of each wave of immigrants. We analyzed the frequency of the CCR5Δ32 allele of the CCR5 chemokine receptor, which is considered a Caucasian marker, in five sample sets from the population. Four were collected in Porto Velho, the state capital and the site of several waves of migration. Of these, two, from the Hospital de Base were comprised of HB Mothers and HB Newborns presenting allele frequencies of 3.5% and 3.1%, respectively, a third from the peri-urban neighborhoods of Candelária/Bate-Estaca (1.8%), whereas a fourth, from the Research Center on Tropical Medicine/CEPEM (0.6%), was composed of malaria patients under treament. The fifth sample (3.4%) came from the inland Quilombola village of Pedras Negras. Two homozygous individuals (CCR5Δ32/CCR5Δ32) were detected among the HB Mother samples. The frequency of this allele was heterogeneous and higher where the European inflow was more pronounced. The presence of the allele in Pedras Negras revealed European miscegenation in a community largely comprising Quilombolas.

No MeSH data available.


Related in: MedlinePlus