Mentions: First, we investigated the effects of plasma CNP on impaired bone growth in achondroplastic mice that specifically overexpress CNP in the liver under the control of human serum amyloid P component promoter. Increased plasma CNP stimulated the impaired growth of achondroplastic bones, and they grew almost comparable to those of wild type mice at the age of 6 weeks. Then we treated achondroplastic mice with continuous intravenous infusion of CNP at the dose of 1 μg/kg/min, and successfully rescued the shortness of most bones formed endochondral ossification at the end of 3-week experimental period. Figures 1 and 2.
No MeSH data available.