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Therapeutic potential of CNP for skeletal dysplasias

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Lengths of bones measured on soft x-ray film.
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Figure 2: Lengths of bones measured on soft x-ray film.

Mentions: First, we investigated the effects of plasma CNP on impaired bone growth in achondroplastic mice that specifically overexpress CNP in the liver under the control of human serum amyloid P component promoter. Increased plasma CNP stimulated the impaired growth of achondroplastic bones, and they grew almost comparable to those of wild type mice at the age of 6 weeks. Then we treated achondroplastic mice with continuous intravenous infusion of CNP at the dose of 1 μg/kg/min, and successfully rescued the shortness of most bones formed endochondral ossification at the end of 3-week experimental period. Figures 1 and 2.


Therapeutic potential of CNP for skeletal dysplasias
Lengths of bones measured on soft x-ray film.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3313390&req=5

Figure 2: Lengths of bones measured on soft x-ray film.
Mentions: First, we investigated the effects of plasma CNP on impaired bone growth in achondroplastic mice that specifically overexpress CNP in the liver under the control of human serum amyloid P component promoter. Increased plasma CNP stimulated the impaired growth of achondroplastic bones, and they grew almost comparable to those of wild type mice at the age of 6 weeks. Then we treated achondroplastic mice with continuous intravenous infusion of CNP at the dose of 1 μg/kg/min, and successfully rescued the shortness of most bones formed endochondral ossification at the end of 3-week experimental period. Figures 1 and 2.

View Article: PubMed Central - HTML

No MeSH data available.


Related in: MedlinePlus