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Dedicated Cone-beam Breast Computed Tomography and Diagnostic Mammography: Comparison of Radiation Dose, Patient Comfort, And Qualitative Review of Imaging Findings in BI-RADS 4 and 5 Lesions.

O'Connell AM, Kawakyu-O'Connor D - J Clin Imaging Sci (2012)

Bottom Line: Mammograms and CBBCT images were compared side-by-side and lesion visibility/conspicuity was qualitatively scored.Patients reported greater comfort in CBBCT imaging relative to mammography.Owing to favorable radiation dose profile, excellent visualization of lesions, and qualitative benefits including improved patient comfort, excellent field-of-view, and more anatomical evaluation of lesion margins, CBBCT offers a promising modality for diagnostic evaluation of breast lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Imaging Sciences, University of Rochester Medical Center, Highland Breast Imaging Center, Rochester, NY, USA.

ABSTRACT

Objective: This pilot study was undertaken to compare radiation dose, relative visibility/conspicuity of biopsy-proven lesions, and relative patient comfort in diagnostic mammography and dedicated cone-beam breast computed tomography (CBBCT) in Breast Imaging-Reporting and Data System (BI-RADS)(®) 4 or 5 lesions.

Materials and methods: Thirty-six consecutive patients (37 breasts) with abnormal mammographic and/or ultrasound categorized as BI-RADS(®) 4 or 5 lesions were evaluated with CBBCT prior to biopsy. Administered radiation dose was calculated for each modality. Mammograms and CBBCT images were compared side-by-side and lesion visibility/conspicuity was qualitatively scored. Histopathology of lesions was reviewed. Patients were administered a survey for qualitative evaluation of comfort between the two modalities.

Results: CBBCT dose was similar to or less than diagnostic mammography, with a mean dose of 9.4 mGy (±3.1 SD) for CBBCT vs. 16.9 mGy (±6.9 SD) for diagnostic mammography in a total of 37 imaged breasts (P<0.001). Thirty-three of 34 mammographic lesions were scored as equally or better visualized in CBBCT relative to diagnostic mammography. Characterization of high-risk lesions was excellent. Patients reported greater comfort in CBBCT imaging relative to mammography.

Conclusion: Our experience of side-by-side comparison of CBBCT and diagnostic mammography in BI-RADS(®) 4 and 5 breast lesions demonstrated a high degree of correlation between the two modalities across a variety of lesion types. Owing to favorable radiation dose profile, excellent visualization of lesions, and qualitative benefits including improved patient comfort, excellent field-of-view, and more anatomical evaluation of lesion margins, CBBCT offers a promising modality for diagnostic evaluation of breast lesions.

No MeSH data available.


Related in: MedlinePlus

A fifty-eight-year-old woman with mammographical mass in the posterior breast. Diagnostic (a) L CC (b) MLO views with detail of region of interest (inset); CBBCT images in (c) transverse and sagittal (through the d) medial and (e) lateral portions of the lesion, respectively) 3.0-mm sections demonstrate spicules extending from the mass anteriorly (arrowheads, c and e) and additional possible satellite nodules (arrows, d).
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Figure 6: A fifty-eight-year-old woman with mammographical mass in the posterior breast. Diagnostic (a) L CC (b) MLO views with detail of region of interest (inset); CBBCT images in (c) transverse and sagittal (through the d) medial and (e) lateral portions of the lesion, respectively) 3.0-mm sections demonstrate spicules extending from the mass anteriorly (arrowheads, c and e) and additional possible satellite nodules (arrows, d).

Mentions: Examples of common mammographic and sonographical lesions with CBBCT correlation were identified, including palpable lump in extremely dense breast [Figure 2], developing asymmetry [Figure 3], mass with benign features [Figure 4], microcalcifications [Figure 5], and partially obscured mass in the posterior breast [Figure 6].


Dedicated Cone-beam Breast Computed Tomography and Diagnostic Mammography: Comparison of Radiation Dose, Patient Comfort, And Qualitative Review of Imaging Findings in BI-RADS 4 and 5 Lesions.

O'Connell AM, Kawakyu-O'Connor D - J Clin Imaging Sci (2012)

A fifty-eight-year-old woman with mammographical mass in the posterior breast. Diagnostic (a) L CC (b) MLO views with detail of region of interest (inset); CBBCT images in (c) transverse and sagittal (through the d) medial and (e) lateral portions of the lesion, respectively) 3.0-mm sections demonstrate spicules extending from the mass anteriorly (arrowheads, c and e) and additional possible satellite nodules (arrows, d).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3307212&req=5

Figure 6: A fifty-eight-year-old woman with mammographical mass in the posterior breast. Diagnostic (a) L CC (b) MLO views with detail of region of interest (inset); CBBCT images in (c) transverse and sagittal (through the d) medial and (e) lateral portions of the lesion, respectively) 3.0-mm sections demonstrate spicules extending from the mass anteriorly (arrowheads, c and e) and additional possible satellite nodules (arrows, d).
Mentions: Examples of common mammographic and sonographical lesions with CBBCT correlation were identified, including palpable lump in extremely dense breast [Figure 2], developing asymmetry [Figure 3], mass with benign features [Figure 4], microcalcifications [Figure 5], and partially obscured mass in the posterior breast [Figure 6].

Bottom Line: Mammograms and CBBCT images were compared side-by-side and lesion visibility/conspicuity was qualitatively scored.Patients reported greater comfort in CBBCT imaging relative to mammography.Owing to favorable radiation dose profile, excellent visualization of lesions, and qualitative benefits including improved patient comfort, excellent field-of-view, and more anatomical evaluation of lesion margins, CBBCT offers a promising modality for diagnostic evaluation of breast lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Imaging Sciences, University of Rochester Medical Center, Highland Breast Imaging Center, Rochester, NY, USA.

ABSTRACT

Objective: This pilot study was undertaken to compare radiation dose, relative visibility/conspicuity of biopsy-proven lesions, and relative patient comfort in diagnostic mammography and dedicated cone-beam breast computed tomography (CBBCT) in Breast Imaging-Reporting and Data System (BI-RADS)(®) 4 or 5 lesions.

Materials and methods: Thirty-six consecutive patients (37 breasts) with abnormal mammographic and/or ultrasound categorized as BI-RADS(®) 4 or 5 lesions were evaluated with CBBCT prior to biopsy. Administered radiation dose was calculated for each modality. Mammograms and CBBCT images were compared side-by-side and lesion visibility/conspicuity was qualitatively scored. Histopathology of lesions was reviewed. Patients were administered a survey for qualitative evaluation of comfort between the two modalities.

Results: CBBCT dose was similar to or less than diagnostic mammography, with a mean dose of 9.4 mGy (±3.1 SD) for CBBCT vs. 16.9 mGy (±6.9 SD) for diagnostic mammography in a total of 37 imaged breasts (P<0.001). Thirty-three of 34 mammographic lesions were scored as equally or better visualized in CBBCT relative to diagnostic mammography. Characterization of high-risk lesions was excellent. Patients reported greater comfort in CBBCT imaging relative to mammography.

Conclusion: Our experience of side-by-side comparison of CBBCT and diagnostic mammography in BI-RADS(®) 4 and 5 breast lesions demonstrated a high degree of correlation between the two modalities across a variety of lesion types. Owing to favorable radiation dose profile, excellent visualization of lesions, and qualitative benefits including improved patient comfort, excellent field-of-view, and more anatomical evaluation of lesion margins, CBBCT offers a promising modality for diagnostic evaluation of breast lesions.

No MeSH data available.


Related in: MedlinePlus